Basic Information:

  VIRBase ID:  

HHID00026187

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3614-5p:  MIMAT0017992          TMC8:  NM_152468     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3614-5p	TMC8
miRBase Accession/Entrez ID	MIMAT0017992	147138
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EV2//EVER2//EVIN2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3614-5p	rs1276310586 chr17:56891320    G/A rs1422621595 chr17:56891335    C/A rs1422621595 chr17:56891335    C/G rs533715139 chr17:56891339    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMC8	chr17:76132306(+) A-I      intronic chr17:76132568(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMC8	chr17:76136407(+) C-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMC8	chr17:76126899-76126900(+) m6A 5'UTR       - chr17:76126911-76126912(+) m6A 5'UTR       - chr17:76127369-76127370(+) m6A 5'UTR       28052920//27371828 chr17:76127480-76127481(+) m6A 5'UTR       27371828 chr17:76127494-76127495(+) m6A 5'UTR//intron       27371828 chr17:76127612-76127613(+) m6A 5'UTR//intron       - chr17:76127802-76127803(+) m6A CDS//intron       - chr17:76127990-76127991(+) m6A CDS//intron       - chr17:76132808-76132809(+) m6A exon//intron       - chr17:76132818-76132819(+) m6A exon//intron       - chr17:76132837-76132838(+) m6A exon//intron       - chr17:76132849-76132850(+) m6A exon//intron       - chr17:76132854-76132855(+) m6A exon//intron       - chr17:76132943-76132944(+) m6A exon//intron       - chr17:76132966-76132967(+) m6A exon//intron       - chr17:76133012-76133013(+) m6A exon//intron       - chr17:76133056-76133057(+) m6A exon//intron       - chr17:76133081-76133082(+) m6A exon//intron       - chr17:76133094-76133095(+) m6A exon//intron       - chr17:76133105-76133106(+) m6A exon//intron       - chr17:76133112-76133113(+) m6A exon//intron       - chr17:76133370-76133371(+) m6A CDS//exon       - chr17:76133392-76133393(+) m6A CDS//exon       - chr17:76133500-76133501(+) m6A exon//intron       - chr17:76136945-76136946(+) m6A CDS//exon       - chr17:76137111-76137112(+) m6A CDS//exon       - chr17:76137132-76137133(+) m6A CDS//exon       - chr17:76137258-76137259(+) m6A 3'UTR//exon       - chr17:76137322-76137323(+) m6A 3'UTR       - chr17:76137584-76137585(+) m6A 3'UTR       - chr17:76137663-76137664(+) m6A 3'UTR       - chr17:76137706-76137707(+) m6A 3'UTR       - chr17:76137751-76137752(+) m6A 3'UTR       - chr17:76137936-76137937(+) m6A 3'UTR       - chr17:76138262-76138263(+) m6A 3'UTR       - chr17:76138348-76138349(+) m6A 3'UTR       25456834 chr17:76138393-76138394(+) m6A 3'UTR       25456834//24981863 chr17:76138472-76138473(+) m6A 3'UTR       25456834//24981863 chr17:76138485-76138486(+) m6A 3'UTR       25456834//24981863 chr17:76138553-76138554(+) m6A 3'UTR       25456834//24981863 chr17:76138626-76138627(+) m6A 3'UTR       25456834//24981863 chr17:76138731-76138732(+) m6A 3'UTR       24209618//25456834//24981863 chr17:76138790-76138791(+) m6A 3'UTR       24209618//25456834//24981863 chr17:76138831-76138832(+) m6A 3'UTR       24209618//25456834//24981863 chr17:76138882-76138883(+) m6A 3'UTR       24209618//25456834//24981863 chr17:76138895-76138896(+) m6A 3'UTR       24209618//25456834//24981863 chr17:76138941-76138942(+) m6A 3'UTR       24981863 chr17:76138960-76138961(+) m6A 3'UTR       - chr17:76138993-76138994(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3614-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TMC8	Chromatin K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3614-5p
Interactor2: TMC8

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Downregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).