Basic Information:

  VIRBase ID:  

HHID00026185

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3614-5p:  MIMAT0017992          TLDC2:  NM_080628     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3614-5p	TLDC2
miRBase Accession/Entrez ID	MIMAT0017992	140711
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf118

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3614-5p	rs1276310586 chr17:56891320    G/A rs1422621595 chr17:56891335    C/A rs1422621595 chr17:56891335    C/G rs533715139 chr17:56891339    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLDC2	chr20:35513441(+) A-I      intronic chr20:35513427(+) A-I      intronic chr20:35514908(+) A-I      intronic chr20:35514571(+) A-I      intronic chr20:35511565(+) A-I      intronic chr20:35514845(+) A-I      intronic chr20:35512268(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLDC2	chr20:35521768-35521769(+) m6A 3'UTR       25456834 chr20:35521809-35521810(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3614-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TLDC2	Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3614-5p
Interactor2: TLDC2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).