Detail Information

Basic Information:


  VIRBase ID:  

HHID00026170

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3614-5p:           TRIM5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3614-5p TRIM5
miRBase
Accession/Entrez ID		 MIMAT0017992 85363
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RNF88//TRIM5alpha

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-3614-5p
rs1276310586 chr17:56891320    G/A
rs1422621595 chr17:56891335    C/A
rs1422621595 chr17:56891335    C/G
rs533715139 chr17:56891339    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM5
chr11:5689458(-) A-I      intronic
chr11:5685228(-) A-I      3'UTR
chr11:5685269(-) A-I      3'UTR
chr11:5685188(-) A-I      3'UTR
chr11:5685220(-) A-I      3'UTR
chr11:5689385(-) A-I      intronic
chr11:5685173(-) A-I      3'UTR
chr11:5685166(-) A-I      3'UTR
chr11:5689417(-) A-I      intronic
chr11:5689448(-) A-I      intronic
chr11:5685362(-) A-I      NonSyn:Thr->Ala
chr11:5685348(-) A-I      Syn:Gln->Gln
chr11:5685368(-) A-I      NonSyn:Thr->Ala
chr11:5685387(-) A-I      Syn:Ala->Ala
chr11:5685344(-) A-I      NonSyn:Ile->Val
chr11:5685331(-) A-I      NonSyn:Gln->Arg
chr11:5685319(-) A-I      NonSyn:Stp->Trp
chr11:5688522(-) A-I      intronic
chr11:5688513(-) A-I      intronic
chr11:5688505(-) A-I      intronic
chr11:5688499(-) A-I      intronic
chr11:5691062(-) A-I      intronic
chr11:5688470(-) A-I      intronic
chr11:5691536(-) A-I      intronic
chr11:5688548(-) A-I      intronic
chr11:5692273(-) A-I      intronic
chr11:5688504(-) A-I      intronic
chr11:5689737(-) A-I      intronic
chr11:5689812(-) A-I      intronic
chr11:5689821(-) A-I      intronic
chr11:5689849(-) A-I      intronic
chr11:5689862(-) A-I      intronic
chr11:5689883(-) A-I      intronic
chr11:5689899(-) A-I      intronic
chr11:5689917(-) A-I      intronic
chr11:5690406(-) A-I      intronic
chr11:5690421(-) A-I      intronic
chr11:5690425(-) A-I      intronic
chr11:5690431(-) A-I      intronic
chr11:5690434(-) A-I      intronic
chr11:5690447(-) A-I      intronic
chr11:5690448(-) A-I      intronic
chr11:5690965(-) A-I      intronic
chr11:5690998(-) A-I      intronic
chr11:5693714(-) A-I      intronic
chr11:5691011(-) A-I      intronic
chr11:5691053(-) A-I      intronic
chr11:5691142(-) A-I      intronic
chr11:5691620(-) A-I      intronic
chr11:5689395(-) A-I      intronic
chr11:5691455(-) A-I      intronic
chr11:5703286(-) A-I      intronic
chr11:5692276(-) A-I      intronic
chr11:5692217(-) A-I      intronic
chr11:5698834(-) A-I      intronic
chr11:5703494(-) A-I      intronic
chr11:5703377(-) A-I      intronic
chr11:5692369(-) A-I      intronic
chr11:5689874(-) A-I      intronic
chr11:5703459(-) A-I      intronic
chr11:5692344(-) A-I      intronic
chr11:5688612(-) A-I      intronic
chr11:5703495(-) A-I      intronic
chr11:5703521(-) A-I      intronic
chr11:5691158(-) A-I      intronic
chr11:5689952(-) A-I      intronic
chr11:5689386(-) A-I      intronic
chr11:5691519(-) A-I      intronic
chr11:5691521(-) A-I      intronic
chr11:5693654(-) A-I      intronic
chr11:5690416(-) A-I      intronic
chr11:5691522(-) A-I      intronic
chr11:5691036(-) A-I      intronic
chr11:5689505(-) A-I      intronic
chr11:5692356(-) A-I      intronic
chr11:5688601(-) A-I      intronic
chr11:5693518(-) A-I      intronic
chr11:5692281(-) A-I      intronic
chr11:5693520(-) A-I      intronic
chr11:5692450(-) A-I      intronic
chr11:5692334(-) A-I      intronic
chr11:5696327(-) A-I      intronic
chr11:5689467(-) A-I      intronic
chr11:5691580(-) A-I      intronic
chr11:5696331(-) A-I      intronic
chr11:5689881(-) A-I      intronic
chr11:5693708(-) A-I      intronic
chr11:5689419(-) A-I      intronic
chr11:5688635(-) A-I      intronic
chr11:5689791(-) A-I      intronic
chr11:5689776(-) A-I      intronic
chr11:5690528(-) A-I      intronic
chr11:5692229(-) A-I      intronic
chr11:5693645(-) A-I      intronic
chr11:5691119(-) A-I      intronic
chr11:5693618(-) A-I      intronic
chr11:5696319(-) A-I      intronic
chr11:5693553(-) A-I      intronic
chr11:5688702(-) A-I      intronic
chr11:5692425(-) A-I      intronic
chr11:5688558(-) A-I      intronic
chr11:5693580(-) A-I      intronic
chr11:5693606(-) A-I      intronic
chr11:5691513(-) A-I      intronic
chr11:5691514(-) A-I      intronic
chr11:5692239(-) A-I      intronic
chr11:5685266(-) A-I      3'UTR
chr11:5685309(-) A-I      3'UTR
chr11:5685230(-) A-I      3'UTR
chr11:5685282(-) A-I      3'UTR
chr11:5685430(-) A-I      3'UTR
chr11:5685240(-) A-I      3'UTR
chr11:5685355(-) A-I      NonSyn:Gln->Arg
chr11:5685323(-) A-I      NonSyn:Lys->Glu
chr11:5685392(-) A-I      NonSyn:Met->Val
chr11:5693590(-) A-I      intronic
chr11:5689953(-) A-I      intronic
chr11:5688575(-) A-I      intronic
chr11:5691610(-) A-I      intronic
chr11:5692253(-) A-I      intronic
chr11:5703193(-) A-I      intronic
chr11:5689396(-) A-I      intronic
chr11:5689453(-) A-I      intronic
chr11:5691123(-) A-I      intronic
chr11:5692307(-) A-I      intronic
chr11:5689930(-) A-I      intronic
chr11:5691060(-) A-I      intronic
chr11:5691043(-) A-I      intronic
chr11:5696433(-) A-I      intronic
chr11:5692373(-) A-I      intronic
chr11:5703390(-) A-I      intronic
chr11:5692324(-) A-I      intronic
chr11:5692454(-) A-I      intronic
chr11:5703383(-) A-I      intronic
chr11:5691198(-) A-I      intronic
chr11:5691048(-) A-I      intronic
chr11:5692290(-) A-I      intronic
chr11:5693579(-) A-I      intronic
chr11:5692308(-) A-I      intronic
chr11:5689898(-) A-I      intronic
chr11:5691121(-) A-I      intronic
chr11:5689808(-) A-I      intronic
chr11:5691096(-) A-I      intronic
chr11:5703462(-) A-I      intronic
chr11:5688574(-) A-I      intronic
chr11:5689464(-) A-I      intronic
chr11:5698940(-) A-I      intronic
chr11:5693615(-) A-I      intronic
chr11:5692396(-) A-I      intronic
chr11:5688471(-) A-I      intronic
chr11:5693713(-) A-I      intronic
chr11:5689844(-) A-I      intronic
chr11:5688616(-) A-I      intronic
chr11:5703471(-) A-I      intronic
chr11:5698931(-) A-I      intronic
chr11:5692370(-) A-I      intronic
chr11:5691148(-) A-I      intronic
chr11:5688494(-) A-I      intronic
chr11:5691546(-) A-I      intronic
chr11:5691143(-) A-I      intronic
chr11:5691122(-) A-I      intronic
chr11:5691023(-) A-I      intronic
chr11:5692361(-) A-I      intronic
chr11:5688569(-) A-I      intronic
chr11:5703223(-) A-I      intronic
chr11:5689380(-) A-I      intronic
chr11:5698932(-) A-I      intronic
chr11:5691093(-) A-I      intronic
chr11:5689382(-) A-I      intronic
chr11:5689859(-) A-I      intronic
chr11:5691105(-) A-I      intronic
chr11:5691572(-) A-I      intronic
chr11:5689817(-) A-I      intronic
chr11:5689409(-) A-I      intronic
chr11:5703161(-) A-I      intronic
chr11:5691671(-) A-I      intronic
chr11:5693565(-) A-I      intronic
chr11:5693539(-) A-I      intronic
chr11:5692394(-) A-I      intronic
chr11:5688565(-) A-I      intronic
chr11:5689718(-) A-I      intronic
chr11:5690971(-) A-I      intronic
chr11:5690993(-) A-I      intronic
chr11:5692288(-) A-I      intronic
chr11:5688704(-) A-I      intronic
chr11:5703386(-) A-I      intronic
chr11:5693611(-) A-I      intronic
chr11:5689491(-) A-I      intronic
chr11:5690969(-) A-I      intronic
chr11:5689392(-) A-I      intronic
chr11:5689756(-) A-I      intronic
chr11:5693624(-) A-I      intronic
chr11:5692442(-) A-I      intronic
chr11:5692387(-) A-I      intronic
chr11:5698810(-) A-I      intronic
chr11:5691480(-) A-I      intronic
chr11:5703041(-) A-I      intronic
chr11:5689873(-) A-I      intronic
chr11:5689818(-) A-I      intronic
chr11:5693609(-) A-I      intronic
chr11:5691672(-) A-I      intronic
chr11:5689331(-) A-I      intronic
chr11:5703451(-) A-I      intronic
chr11:5692299(-) A-I      intronic
chr11:5690582(-) A-I      intronic
chr11:5688615(-) A-I      intronic
chr11:5690415(-) A-I      intronic
chr11:5691010(-) A-I      intronic
chr11:5688472(-) A-I      intronic
chr11:5690583(-) A-I      intronic
chr11:5689931(-) A-I      intronic
chr11:5691118(-) A-I      intronic
chr11:5689418(-) A-I      intronic
chr11:5685187(-) A-I      3'UTR
chr11:5685175(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRIM5
chr11:5689382(-) A-I intron -    22327324
chr11:5689464(-) A-I intron -    22327324
chr11:5689818(-) A-I intron -    22327324
chr11:5689953(-) A-I intron -    22327324
chr11:5691105(-) A-I intron -    22327324
chr11:5691122(-) A-I intron -    22327324
chr11:5691672(-) A-I intron -    22327324
chr11:5692334(-) A-I intron -    22327324
chr11:5692394(-) A-I intron -    22327324
chr11:5693606(-) A-I intron -    22327324
chr11:5693713(-) A-I intron -    22327324
chr11:5692273(-) A-I intron -    21960545
chr11:5688504(-) A-G intron -    22484847
chr11:5689331(-) A-G intron -    22484847
chr11:5689382(-) A-G intron -    22484847
chr11:5689392(-) A-G intron -    22484847
chr11:5689396(-) A-G intron -    22484847
chr11:5689419(-) A-G intron -    22484847
chr11:5689453(-) A-G intron -    22484847
chr11:5689464(-) A-G intron -    22484847
chr11:5689791(-) A-G intron -    22484847
chr11:5689808(-) A-G intron -    22484847
chr11:5689817(-) A-G intron -    22484847
chr11:5689818(-) A-G intron -    22484847
chr11:5689881(-) A-G intron -    22484847
chr11:5689931(-) A-G intron -    22484847
chr11:5689953(-) A-G intron -    22484847
chr11:5690415(-) A-G intron -    22484847
chr11:5690416(-) A-G intron -    22484847
chr11:5690583(-) A-G intron -    22484847
chr11:5691105(-) A-G intron -    22484847
chr11:5691121(-) A-G intron -    22484847
chr11:5691122(-) A-G intron -    22484847
chr11:5691123(-) A-G intron -    22484847
chr11:5691480(-) A-G intron -    22484847
chr11:5691513(-) A-G intron -    22484847
chr11:5691672(-) A-G intron -    22484847
chr11:5692273(-) A-G intron -    22484847
chr11:5692290(-) A-G intron -    22484847
chr11:5692334(-) A-G intron -    22484847
chr11:5692370(-) A-G intron -    22484847
chr11:5692394(-) A-G intron -    22484847
chr11:5692425(-) A-G intron -    22484847
chr11:5693606(-) A-G intron -    22484847
chr11:5693713(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM5
chr11:5684846-5684847(-) m6A 3'UTR       27773535
chr11:5684853-5684854(-) m6A 3'UTR       27773535
chr11:5684914-5684915(-) m6A 3'UTR       27773535
chr11:5685777-5685778(-) m6A 3'UTR//intron       27773535
chr11:5685802-5685803(-) m6A 3'UTR//intron       27773535
chr11:5685972-5685973(-) m6A 3'UTR//intron       27773535
chr11:5686037-5686038(-) m6A 3'UTR//intron       27773535
chr11:5686153-5686154(-) m6A 3'UTR//CDS//intron       27773535
chr11:5686192-5686193(-) m6A 3'UTR//CDS//intron       27773535
chr11:5686415-5686416(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr11:5686446-5686447(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686508-5686509(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686520-5686521(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686548-5686549(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686566-5686567(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686603-5686604(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr11:5687279-5687280(-) m6A CDS//exon//intron       27773535
chr11:5699326-5699327(-) m6A exon//intron       -
chr11:5699504-5699505(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chr11:5699522-5699523(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chr11:5699530-5699531(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chr11:5699551-5699552(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22608085
chr11:5699572-5699573(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr11:5699599-5699600(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:5699608-5699609(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:5699642-5699643(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:5701104-5701105(-) m6A CDS//exon       27773535
chr11:5701210-5701211(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828
chr11:5701261-5701262(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr11:5701282-5701283(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:5701321-5701322(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:5701347-5701348(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:5701433-5701434(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr11:5701448-5701449(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr11:5701457-5701458(-) m6A 5'UTR       24284625//24209618//27371828
chr11:5705223-5705224(-) m6A 5'UTR//intron       24284625//24209618//27371828
chr11:5706111-5706112(-) m6A 5'UTR//intron       24981863//27773535
chr11:5706116-5706117(-) m6A 5'UTR//intron       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3614-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
TRIM5
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3614-5p
Interactor2: TRIM5

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Upregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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