Basic Information:

  VIRBase ID:  

HHID00026162

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3614-5p:  MIMAT0017992          PDCD1LG2:  NM_025239     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3614-5p	PDCD1LG2
miRBase Accession/Entrez ID	MIMAT0017992	80380
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	B7DC//bA574F11.2//Btdc//CD273//PD-L2//PDCD1L2//PDL2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3614-5p	rs1276310586 chr17:56891320    G/A rs1422621595 chr17:56891335    C/A rs1422621595 chr17:56891335    C/G rs533715139 chr17:56891339    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDCD1LG2	chr9:5526621(+) A-I      intronic chr9:5526461(+) A-I      intronic chr9:5525270(+) A-I      intronic chr9:5515736(+) A-I      intronic chr9:5528519(+) A-I      intronic chr9:5515751(+) A-I      intronic chr9:5515771(+) A-I      intronic chr9:5515776(+) A-I      intronic chr9:5515838(+) A-I      intronic chr9:5515843(+) A-I      intronic chr9:5515918(+) A-I      intronic chr9:5526538(+) A-I      intronic chr9:5516152(+) A-I      intronic chr9:5515816(+) A-I      intronic chr9:5526658(+) A-I      intronic chr9:5526571(+) A-I      intronic chr9:5525265(+) A-I      intronic chr9:5526567(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDCD1LG2	chr9:5525265(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDCD1LG2	chr9:5534982-5534983(+) m6A CDS       24981863 chr9:5535020-5535021(+) m6A CDS       24981863 chr9:5549352-5549353(+) m6A CDS       24981863 chr9:5549378-5549379(+) m6A CDS       24981863 chr9:5563174-5563175(+) m6A CDS       24981863 chr9:5563203-5563204(+) m6A CDS       24981863 chr9:5569959-5569960(+) m6A 3'UTR       24981863 chr9:5570014-5570015(+) m6A 3'UTR       24981863 chr9:5570021-5570022(+) m6A 3'UTR       24981863 chr9:5570099-5570100(+) m6A 3'UTR       24209618//24981863 chr9:5570111-5570112(+) m6A 3'UTR       24209618//24981863 chr9:5570134-5570135(+) m6A 3'UTR       24209618//24981863 chr9:5570156-5570157(+) m6A 3'UTR       24209618//24981863 chr9:5570227-5570228(+) m6A 3'UTR       24209618//24981863 chr9:5570264-5570265(+) m6A 3'UTR       24209618//24981863 chr9:5570349-5570350(+) m6A 3'UTR       24981863 chr9:5570418-5570419(+) m6A 3'UTR       24981863 chr9:5570433-5570434(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3614-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PDCD1LG2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3614-5p
Interactor2: PDCD1LG2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).