Basic Information:

  VIRBase ID:  

HHID00026159

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3614-5p:  MIMAT0017992          LPIN3:  NM_001301860     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3614-5p	LPIN3
miRBase Accession/Entrez ID	MIMAT0017992	64900
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	dJ620E11.2//LIPN3L//SMP2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3614-5p	rs1276310586 chr17:56891320    G/A rs1422621595 chr17:56891335    C/A rs1422621595 chr17:56891335    C/G rs533715139 chr17:56891339    T/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LPIN3	chr20:39974447-39974448(+) m6A CDS       24284625 chr20:39974510-39974511(+) m6A CDS       24284625 chr20:39977416-39977417(+) m6A CDS       - chr20:39977464-39977465(+) m6A CDS       - chr20:39980526-39980527(+) m6A CDS       24284625 chr20:39980732-39980733(+) m6A CDS       24981863 chr20:39983360-39983361(+) m6A CDS//intron       24284625 chr20:39983480-39983481(+) m6A CDS       24981863 chr20:39984542-39984543(+) m6A CDS       24981863 chr20:39984576-39984577(+) m6A CDS       24981863 chr20:39985689-39985690(+) m6A CDS       24981863 chr20:39987426-39987427(+) m6A CDS//exon       24284625//24981863 chr20:39987486-39987487(+) m6A CDS//exon       24284625//24981863 chr20:39987501-39987502(+) m6A CDS//exon       24284625//25456834//24981863 chr20:39987506-39987507(+) m6A 3'UTR//exon       24284625//25456834//24981863 chr20:39987546-39987547(+) m6A 3'UTR       24284625//25456834//24981863 chr20:39987601-39987602(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr20:39987651-39987652(+) m6A 3'UTR       25456834//24981863 chr20:39988126-39988127(+) m6A 3'UTR       25456834//24981863 chr20:39988149-39988150(+) m6A 3'UTR       24284625//25456834//24981863 chr20:39988234-39988235(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr20:39988271-39988272(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr20:39988291-39988292(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr20:39988420-39988421(+) m6A 3'UTR       24284625//24981863 chr20:39988433-39988434(+) m6A 3'UTR       24284625//24981863 chr20:39988443-39988444(+) m6A 3'UTR       24284625//24981863 chr20:39988606-39988607(+) m6A 3'UTR       - chr20:39988685-39988686(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr20:39988706-39988707(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr20:39988749-39988750(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr20:39988774-39988775(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr20:39988797-39988798(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr20:39988815-39988816(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr20:39988874-39988875(+) m6A 3'UTR       - chr20:39989043-39989044(+) m6A 3'UTR       - chr20:39989071-39989072(+) m6A 3'UTR       - chr20:39989124-39989125(+) m6A 3'UTR       25456834//24981863//27773535//22608085 chr20:39989210-39989211(+) m6A 3'UTR       25456834//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3614-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	LPIN3	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3614-5p
Interactor2: LPIN3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).