Basic Information:

  VIRBase ID:  

HHID00026029

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3614-5p:  MIMAT0017992          ATF3:  NM_001674     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3614-5p	ATF3
miRBase Accession/Entrez ID	MIMAT0017992	467
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3614-5p	rs1276310586 chr17:56891320    G/A rs1422621595 chr17:56891335    C/A rs1422621595 chr17:56891335    C/G rs533715139 chr17:56891339    T/C

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	ATF3	chr1: 212787266

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATF3	chr1:212789196(+) A-I      intronic chr1:212789732(+) A-I      intronic chr1:212789778(+) A-I      intronic chr1:212789231(+) A-I      intronic chr1:212789849(+) A-I      intronic chr1:212789916(+) A-I      intronic chr1:212788888(+) A-I      intronic chr1:212789719(+) A-I      intronic chr1:212788919(+) A-I      intronic chr1:212789066(+) A-I      intronic chr1:212745183(+) A-I      intronic chr1:212788911(+) A-I      intronic chr1:212787266(+) A-I      ncRNA chr1:212789217(+) A-I      intronic chr1:212789116(+) A-I      intronic chr1:212789101(+) A-I      intronic chr1:212789025(+) A-I      intronic chr1:212789232(+) A-I      intronic chr1:212789042(+) A-I      intronic chr1:212788966(+) A-I      intronic chr1:212753840(+) A-I      intronic chr1:212787786(+) A-I      intronic chr1:212788942(+) A-I      intronic chr1:212789199(+) A-I      intronic chr1:212789088(+) A-I      intronic chr1:212787744(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATF3	chr1:212787266(+) A-I intron -    19478186   //21960545 chr1:212789217(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATF3	chr1:212782216-212782217(+) m6A 5'UTR//exon//intron       24981863 chr1:212788514-212788515(+) m6A 5'UTR//CDS//exon//intron       27773535 chr1:212788572-212788573(+) m6A CDS//exon//intron       24981863//27773535 chr1:212791541-212791542(+) m6A CDS//exon//intron       24981863//27773535 chr1:212791660-212791661(+) m6A exon//intron       27773535//22608085 chr1:212791970-212791971(+) m6A exon//intron       24981863 chr1:212792107-212792108(+) m6A exon//intron       25456834//24981863 chr1:212792731-212792732(+) m6A 3'UTR//CDS//exon       24209618//24981863//22608085 chr1:212792834-212792835(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr1:212792853-212792854(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr1:212792882-212792883(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr1:212792956-212792957(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//22608085 chr1:212793015-212793016(+) m6A 3'UTR//exon       24284625//24981863//26404942//22608085 chr1:212793084-212793085(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr1:212793206-212793207(+) m6A 3'UTR//exon       24284625//24981863 chr1:212793322-212793323(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535 chr1:212793408-212793409(+) m6A 3'UTR//exon       24284625//24981863//27773535 chr1:212793573-212793574(+) m6A 3'UTR//exon       24284625 chr1:212793637-212793638(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3614-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ATF3	Chromatin K562 cells     - Cytoplasm Human hepatoma cell line (HepG2)     16109718 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3614-5p
Interactor2: ATF3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).