Basic Information:

  VIRBase ID:  

HHID00026012

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3182:  MIMAT0015062          MLKL:  NM_152649     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3182	MLKL
miRBase Accession/Entrez ID	MIMAT0015062	197259
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hMLKL

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3182	rs1367036983 chr16:83508358    G/A rs564683390 chr16:83508360    G/A rs923654044 chr16:83508365    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MLKL	chr16:74715083(-) A-I      intronic chr16:74715072(-) A-I      intronic chr16:74713613(-) A-I      intronic chr16:74713540(-) A-I      intronic chr16:74713513(-) A-I      intronic chr16:74713488(-) A-I      intronic chr16:74713476(-) A-I      intronic chr16:74713589(-) A-I      intronic chr16:74712572(-) A-I      intronic chr16:74712477(-) A-I      intronic chr16:74717407(-) A-I      intronic chr16:74708147(-) A-I      intronic chr16:74711756(-) A-I      intronic chr16:74720006(-) A-I      intronic chr16:74719996(-) A-I      intronic chr16:74717418(-) A-I      intronic chr16:74717411(-) A-I      intronic chr16:74717408(-) A-I      intronic chr16:74717370(-) A-I      intronic chr16:74717124(-) A-I      intronic chr16:74717095(-) A-I      intronic chr16:74717067(-) A-I      intronic chr16:74715088(-) A-I      intronic chr16:74717974(-) A-I      intronic chr16:74717984(-) A-I      intronic chr16:74718010(-) A-I      intronic chr16:74718013(-) A-I      intronic chr16:74718022(-) A-I      intronic chr16:74718039(-) A-I      intronic chr16:74718042(-) A-I      intronic chr16:74718078(-) A-I      intronic chr16:74718092(-) A-I      intronic chr16:74718561(-) A-I      intronic chr16:74718860(-) A-I      intronic chr16:74718927(-) A-I      intronic chr16:74718932(-) A-I      intronic chr16:74718944(-) A-I      intronic chr16:74718980(-) A-I      intronic chr16:74715128(-) A-I      intronic chr16:74715048(-) A-I      intronic chr16:74715015(-) A-I      intronic chr16:74714999(-) A-I      intronic chr16:74714670(-) A-I      intronic chr16:74714569(-) A-I      intronic chr16:74714558(-) A-I      intronic chr16:74714549(-) A-I      intronic chr16:74714490(-) A-I      intronic chr16:74714477(-) A-I      intronic chr16:74713591(-) A-I      intronic chr16:74712658(-) A-I      intronic chr16:74712599(-) A-I      intronic chr16:74712594(-) A-I      intronic chr16:74712573(-) A-I      intronic chr16:74712553(-) A-I      intronic chr16:74712425(-) A-I      intronic chr16:74712419(-) A-I      intronic chr16:74711614(-) A-I      intronic chr16:74711597(-) A-I      intronic chr16:74711549(-) A-I      intronic chr16:74711472(-) A-I      intronic chr16:74711364(-) A-I      intronic chr16:74711333(-) A-I      intronic chr16:74713630(-) A-I      intronic chr16:74711099(-) A-I      intronic chr16:74711048(-) A-I      intronic chr16:74708378(-) A-I      intronic chr16:74711583(-) A-I      intronic chr16:74717276(-) A-I      intronic chr16:74717259(-) A-I      intronic chr16:74717249(-) A-I      intronic chr16:74717085(-) A-I      intronic chr16:74717069(-) A-I      intronic chr16:74717058(-) A-I      intronic chr16:74717044(-) A-I      intronic chr16:74717041(-) A-I      intronic chr16:74717027(-) A-I      intronic chr16:74717004(-) A-I      intronic chr16:74716142(-) A-I      intronic chr16:74711118(-) A-I      intronic chr16:74718014(-) A-I      intronic chr16:74716132(-) A-I      intronic chr16:74716042(-) A-I      intronic chr16:74716041(-) A-I      intronic chr16:74715909(-) A-I      intronic chr16:74715885(-) A-I      intronic chr16:74715543(-) A-I      intronic chr16:74719035(-) A-I      intronic chr16:74719041(-) A-I      intronic chr16:74720299(-) A-I      intronic chr16:74720322(-) A-I      intronic chr16:74720369(-) A-I      intronic chr16:74727217(-) A-I      intronic chr16:74720373(-) A-I      intronic chr16:74715473(-) A-I      intronic chr16:74715191(-) A-I      intronic chr16:74721951(-) A-I      intronic chr16:74728613(-) A-I      intronic chr16:74728608(-) A-I      intronic chr16:74728592(-) A-I      intronic chr16:74728491(-) A-I      intronic chr16:74728428(-) A-I      intronic chr16:74727773(-) A-I      intronic chr16:74727676(-) A-I      intronic chr16:74727666(-) A-I      intronic chr16:74727231(-) A-I      intronic chr16:74727218(-) A-I      intronic chr16:74721101(-) A-I      intronic chr16:74721130(-) A-I      intronic chr16:74721862(-) A-I      intronic chr16:74721903(-) A-I      intronic chr16:74721904(-) A-I      intronic chr16:74717289(-) A-I      intronic chr16:74722076(-) A-I      intronic chr16:74722114(-) A-I      intronic chr16:74722154(-) A-I      intronic chr16:74722432(-) A-I      intronic chr16:74722500(-) A-I      intronic chr16:74722525(-) A-I      intronic chr16:74723019(-) A-I      intronic chr16:74723193(-) A-I      intronic chr16:74717957(-) A-I      intronic chr16:74717954(-) A-I      intronic chr16:74717914(-) A-I      intronic chr16:74717372(-) A-I      intronic chr16:74717354(-) A-I      intronic chr16:74717346(-) A-I      intronic chr16:74717290(-) A-I      intronic chr16:74720018(-) A-I      intronic chr16:74728624(-) A-I      intronic chr16:74712437(-) A-I      intronic chr16:74727266(-) A-I      intronic chr16:74714684(-) A-I      intronic chr16:74720054(-) A-I      intronic chr16:74712464(-) A-I      intronic chr16:74712498(-) A-I      intronic chr16:74711741(-) A-I      intronic chr16:74714692(-) A-I      intronic chr16:74711535(-) A-I      intronic chr16:74711349(-) A-I      intronic chr16:74718621(-) A-I      intronic chr16:74722382(-) A-I      intronic chr16:74718970(-) A-I      intronic chr16:74713480(-) A-I      intronic chr16:74714983(-) A-I      intronic chr16:74716140(-) A-I      intronic chr16:74713644(-) A-I      intronic chr16:74714637(-) A-I      intronic chr16:74717250(-) A-I      intronic chr16:74713446(-) A-I      intronic chr16:74711089(-) A-I      intronic chr16:74715182(-) A-I      intronic chr16:74715432(-) A-I      intronic chr16:74723051(-) A-I      intronic chr16:74714608(-) A-I      intronic chr16:74712533(-) A-I      intronic chr16:74715524(-) A-I      intronic chr16:74714994(-) A-I      intronic chr16:74718652(-) A-I      intronic chr16:74711715(-) A-I      intronic chr16:74714526(-) A-I      intronic chr16:74712581(-) A-I      intronic chr16:74727102(-) A-I      intronic chr16:74715061(-) A-I      intronic chr16:74714678(-) A-I      intronic chr16:74715118(-) A-I      intronic chr16:74714689(-) A-I      intronic chr16:74708377(-) A-I      intronic chr16:74721820(-) A-I      intronic chr16:74711480(-) A-I      intronic chr16:74727209(-) A-I      intronic chr16:74711838(-) A-I      intronic chr16:74715101(-) A-I      intronic chr16:74722440(-) A-I      intronic chr16:74715196(-) A-I      intronic chr16:74715080(-) A-I      intronic chr16:74727096(-) A-I      intronic chr16:74711223(-) A-I      intronic chr16:74713650(-) A-I      intronic chr16:74711869(-) A-I      intronic chr16:74711751(-) A-I      intronic chr16:74714533(-) A-I      intronic chr16:74715038(-) A-I      intronic chr16:74713707(-) A-I      intronic chr16:74711361(-) A-I      intronic chr16:74716094(-) A-I      intronic chr16:74715435(-) A-I      intronic chr16:74712692(-) A-I      intronic chr16:74711079(-) A-I      intronic chr16:74711492(-) A-I      intronic chr16:74711377(-) A-I      intronic chr16:74719982(-) A-I      intronic chr16:74717020(-) A-I      intronic chr16:74718571(-) A-I      intronic chr16:74715062(-) A-I      intronic chr16:74717328(-) A-I      intronic chr16:74717337(-) A-I      intronic chr16:74715971(-) A-I      intronic chr16:74711381(-) A-I      intronic chr16:74717425(-) A-I      intronic chr16:74715097(-) A-I      intronic chr16:74712452(-) A-I      intronic chr16:74711453(-) A-I      intronic chr16:74716029(-) A-I      intronic chr16:74722536(-) A-I      intronic chr16:74714952(-) A-I      intronic chr16:74716053(-) A-I      intronic chr16:74716015(-) A-I      intronic chr16:74715961(-) A-I      intronic chr16:74717394(-) A-I      intronic chr16:74718981(-) A-I      intronic chr16:74717302(-) A-I      intronic chr16:74717015(-) A-I      intronic chr16:74717059(-) A-I      intronic chr16:74711781(-) A-I      intronic chr16:74728568(-) A-I      intronic chr16:74711828(-) A-I      intronic chr16:74714575(-) A-I      intronic chr16:74707756(-) A-I      intronic chr16:74711135(-) A-I      intronic chr16:74711701(-) A-I      intronic chr16:74711851(-) A-I      intronic chr16:74711121(-) A-I      intronic chr16:74714578(-) A-I      intronic chr16:74727283(-) A-I      intronic chr16:74727149(-) A-I      intronic chr16:74711673(-) A-I      intronic chr16:74715127(-) A-I      intronic chr16:74718490(-) A-I      intronic chr16:74715031(-) A-I      intronic chr16:74712515(-) A-I      intronic chr16:74728528(-) A-I      intronic chr16:74712518(-) A-I      intronic chr16:74711390(-) A-I      intronic chr16:74713585(-) A-I      intronic chr16:74716058(-) A-I      intronic chr16:74712559(-) A-I      intronic chr16:74711152(-) A-I      intronic chr16:74722455(-) A-I      intronic chr16:74718936(-) A-I      intronic chr16:74714545(-) A-I      intronic chr16:74720139(-) A-I      intronic chr16:74724548(-) A-I      intronic chr16:74722401(-) A-I      intronic chr16:74719017(-) A-I      intronic chr16:74711169(-) A-I      intronic chr16:74712680(-) A-I      intronic chr16:74715510(-) A-I      intronic chr16:74711779(-) A-I      intronic chr16:74714573(-) A-I      intronic chr16:74728585(-) A-I      intronic chr16:74717099(-) A-I      intronic chr16:74716031(-) A-I      intronic chr16:74716096(-) A-I      intronic chr16:74707777(-) A-I      intronic chr16:74719925(-) A-I      intronic chr16:74720224(-) A-I      intronic chr16:74711043(-) A-I      intronic chr16:74712598(-) A-I      intronic chr16:74711702(-) A-I      intronic chr16:74714645(-) A-I      intronic chr16:74718573(-) A-I      intronic chr16:74714624(-) A-I      intronic chr16:74716964(-) A-I      intronic chr16:74711584(-) A-I      intronic chr16:74711125(-) A-I      intronic chr16:74707723(-) A-I      intronic chr16:74717002(-) A-I      intronic chr16:74713523(-) A-I      intronic chr16:74711342(-) A-I      intronic chr16:74718572(-) A-I      intronic chr16:74727573(-) A-I      intronic chr16:74714583(-) A-I      intronic chr16:74718626(-) A-I      intronic chr16:74712674(-) A-I      intronic chr16:74722342(-) A-I      intronic chr16:74712618(-) A-I      intronic chr16:74711628(-) A-I      intronic chr16:74713583(-) A-I      intronic chr16:74713503(-) A-I      intronic chr16:74715117(-) A-I      intronic chr16:74712605(-) A-I      intronic chr16:74715103(-) A-I      intronic chr16:74712524(-) A-I      intronic chr16:74715170(-) A-I      intronic chr16:74719990(-) A-I      intronic chr16:74711709(-) A-I      intronic chr16:74716071(-) A-I      intronic chr16:74718940(-) A-I      intronic chr16:74715502(-) A-I      intronic chr16:74728629(-) A-I      intronic chr16:74711844(-) A-I      intronic chr16:74714581(-) A-I      intronic chr16:74711810(-) A-I      intronic chr16:74730992(-) A-I      intronic chr16:74711047(-) A-I      intronic chr16:74708148(-) A-I      intronic chr16:74708395(-) A-I      intronic chr16:74714998(-) A-I      intronic chr16:74712672(-) A-I      intronic chr16:74714516(-) A-I      intronic chr16:74711391(-) A-I      intronic chr16:74721994(-) A-I      intronic chr16:74707779(-) A-I      intronic chr16:74715175(-) A-I      intronic chr16:74716217(-) A-I      intronic chr16:74711777(-) A-I      intronic chr16:74715100(-) A-I      intronic chr16:74726968(-) A-I      intronic chr16:74711679(-) A-I      intronic chr16:74711501(-) A-I      intronic chr16:74718223(-) A-I      intronic chr16:74711132(-) A-I      intronic chr16:74714194(-) A-I      intronic chr16:74728935(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MLKL	chr16:74705961(-) A-I exon 3'UTR    15342557 chr16:74706349(-) A-I exon 3'UTR    15342557 chr16:74710254(-) A-I intron -    15342557 chr16:74710728(-) A-I intron -    15342557 chr16:74711043(-) A-I intron -    15342557 chr16:74711673(-) A-I intron -    15342557 chr16:74711701(-) A-I intron -    15342557 chr16:74711741(-) A-I intron -    15342557 chr16:74711751(-) A-I intron -    15342557 chr16:74711777(-) A-I intron -    15342557 chr16:74711779(-) A-I intron -    15342557 chr16:74711781(-) A-I intron -    15342557 chr16:74711810(-) A-I intron -    15342557 chr16:74711838(-) A-I intron -    15342557 chr16:74711964(-) A-I intron -    15342557 chr16:74715061(-) A-I intron -    22327324 chr16:74708148(-) A-G intron -    22484847 chr16:74712598(-) A-G intron -    22484847 chr16:74712674(-) A-G intron -    22484847 chr16:74714983(-) A-G intron -    22484847 chr16:74714994(-) A-G intron -    22484847 chr16:74714998(-) A-G intron -    22484847 chr16:74715061(-) A-G intron -    22484847 chr16:74715971(-) A-G intron -    22484847 chr16:74717015(-) A-G intron -    22484847 chr16:74720139(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MLKL	chr16:74705830-74705831(-) m6A 3'UTR//exon       24284625//24981863//27773535 chr16:74705839-74705840(-) m6A 3'UTR//exon       24284625//24981863//27773535 chr16:74705911-74705912(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828 chr16:74705927-74705928(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828 chr16:74705959-74705960(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//27371828 chr16:74705976-74705977(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535 chr16:74706209-74706210(-) m6A 3'UTR//exon       24284625//24981863//27773535 chr16:74706240-74706241(-) m6A 3'UTR//exon       24284625 chr16:74706341-74706342(-) m6A 3'UTR//exon       24981863 chr16:74706346-74706347(-) m6A 3'UTR//exon       24981863 chr16:74706364-74706365(-) Am 3'UTR//exon       - chr16:74726251-74726252(-) m6A CDS       24981863 chr16:74729224-74729225(-) m6A CDS       24981863//22575960 chr16:74729350-74729351(-) m6A CDS       24981863//22575960 chr16:74729374-74729375(-) m6A CDS       24981863 chr16:74729467-74729468(-) m6A CDS       24284625 chr16:74729515-74729516(-) m6A CDS       24284625 chr16:74729577-74729578(-) m6A CDS       24284625//27371828 chr16:74734383-74734384(-) Cm 5'UTR       - chr16:74734384-74734385(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734396-74734397(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734456-74734457(-) m6A 5'UTR//intron       24284625//24981863//27371828 chr16:74734481-74734482(-) m6A 5'UTR//intron       24284625//24981863//27371828 chr16:74734621-74734622(-) m6A 5'UTR       24284625//24981863//27371828//22575960 chr16:74734649-74734650(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734655-74734656(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734686-74734687(-) m6A 5'UTR       24284625//24981863//27371828 chr16:74734829-74734830(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3182	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	MLKL	Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3182
Interactor2: MLKL

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).