Basic Information:

  VIRBase ID:  

HHID00025913

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3182:  MIMAT0015062          KLF4:  NM_004235     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3182	KLF4
miRBase Accession/Entrez ID	MIMAT0015062	9314
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EZF//GKLF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3182	rs1367036983 chr16:83508358    G/A rs564683390 chr16:83508360    G/A rs923654044 chr16:83508365    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KLF4	chr9:110247697-110247698(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085 chr9:110247776-110247777(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960//22608085 chr9:110247841-110247842(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr9:110247855-110247856(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr9:110248023-110248024(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085 chr9:110248065-110248066(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chr9:110248124-110248125(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085 chr9:110248145-110248146(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085 chr9:110248199-110248200(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chr9:110249317-110249318(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chr9:110249356-110249357(-) m6A CDS//exon       24284625//24981863//27773535//22575960 chr9:110249395-110249396(-) m6A CDS//exon       24284625//24981863//27773535 chr9:110249512-110249513(-) m6A exon//intron       24284625//24981863//27773535 chr9:110249688-110249689(-) m6A CDS//exon//intron       24284625//25456834//24981863//27773535 chr9:110249731-110249732(-) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//27773536 chr9:110249801-110249802(-) m6A CDS//exon//intron       24284625//24981863//27371828//27773536 chr9:110250048-110250049(-) m6A CDS//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr9:110250108-110250109(-) m6A CDS//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960 chr9:110250357-110250358(-) m6A CDS//exon//intron       24284625//24981863 chr9:110250363-110250364(-) m6A CDS//exon//intron       24284625//24981863 chr9:110250388-110250389(-) m6A CDS//exon//intron       24284625//24981863 chr9:110250456-110250457(-) m6A CDS//exon//intron       24284625//24981863 chr9:110250585-110250586(-) m6A exon//intron       24284625 chr9:110251239-110251240(-) m6A CDS//exon       24284625 chr9:110251406-110251407(-) m6A 5'UTR//intron       24284625//27773535 chr9:110251473-110251474(-) m6A 5'UTR//exon       24284625//27773535 chr9:110251616-110251617(-) m6A 5'UTR//exon       24284625//24981863//27773535 chr9:110251634-110251635(-) m6A 5'UTR//exon       24284625//24981863//27773535 chr9:110251689-110251690(-) m6A 5'UTR//exon       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3182	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	KLF4	Cytoplasm NSCLC tissue     29665649 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus NSCLC tissue     29665649 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3182
Interactor2: KLF4

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).