Detail Information

Basic Information:


  VIRBase ID:  

HHID00025774

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1246:           ZMAT3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1246 ZMAT3
miRBase
Accession/Entrez ID		 MIMAT0005898 64393
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PAG608//WIG-1//WIG1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1246
rs1489969781 chr2:176601041    T/C
rs757265617 chr2:176601037    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZMAT3
chr3:178748281(-) A-I      intronic
chr3:178748303(-) A-I      intronic
chr3:178748370(-) A-I      intronic
chr3:178749576(-) A-I      intronic
chr3:178749657(-) A-I      intronic
chr3:178782333(-) A-I      intronic
chr3:178782438(-) A-I      intronic
chr3:178782514(-) A-I      intronic
chr3:178746785(-) A-I      intronic
chr3:178746826(-) A-I      intronic
chr3:178746908(-) A-I      intronic
chr3:178782498(-) A-I      intronic
chr3:178782315(-) A-I      intronic
chr3:178749529(-) A-I      intronic
chr3:178749503(-) A-I      intronic
chr3:178782320(-) A-I      intronic
chr3:178748319(-) A-I      intronic
chr3:178749515(-) A-I      intronic
chr3:178749573(-) A-I      intronic
chr3:178748414(-) A-I      intronic
chr3:178749583(-) A-I      intronic
chr3:178744351(-) A-I      intronic
chr3:178762265(-) A-I      intronic
chr3:178783601(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZMAT3
chr3:178740951(-) G-A exon 3'UTR    22484847
chr3:178744455(-) G-C intron -    22484847
chr3:178748414(-) A-G intron -    22484847
chr3:178749503(-) A-G intron -    22484847
chr3:178749515(-) A-G intron -    22484847
chr3:178749529(-) A-G intron -    22484847
chr3:178749573(-) A-G intron -    22484847
chr3:178749583(-) A-G intron -    22484847
chr3:178765486(-) G-T intron -    22484847
chr3:178778367(-) T-C intron -    22484847
chr3:178782498(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZMAT3
chr3:178738549-178738550(-) m6A 3'UTR       -
chr3:178738614-178738615(-) m6A 3'UTR       -
chr3:178742341-178742342(-) m6A 3'UTR       -
chr3:178748766-178748767(-) m6A CDS       24981863//27773535//22608085
chr3:178785301-178785302(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:178785321-178785322(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:178785361-178785362(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr3:178785388-178785389(-) m1A CDS       26863196
chr3:178785452-178785453(-) m6A CDS       24284625//24981863//22575960
chr3:178785588-178785589(-) m6A 5'UTR       -
chr3:178789557-178789558(-) m6A 5'UTR       25456834//24981863//27371828
chr3:178789819-178789820(-) m6A 5'UTR       27371828
chr3:178789857-178789858(-) m6A 5'UTR       27371828
chr3:178789948-178789949(-) m6A 5'UTR       24981863//27371828
chr3:178789957-178789958(-) m6A 5'UTR       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1246
Exosome Sera     25388097
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Saliva     27573701
Exosome Plasma     29143228
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Plasma     23663360
Exosome Serum     24683445
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|B lymphoblastoid cells|Breast tissue|Colon tissue|Epithelial cells|Lymphoma tissue|Mast cells|Mesenchymal stem cells|Tongue tissue     -
Extracellular vesicle Plasma     32498409
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
ZMAT3
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1246
10-Hydroxycamptothecin 97226 Drug interaction    RC00007762
Gemcitabine 60750 Drug interaction    RC00007761
Vincristine 5978 Drug interaction    RC00007758
Ascorbic acid 54670067 Drug interaction    RC00007765
Vorinostat 5311 Drug interaction    RC00007757
Eloxatine 5310940 Drug interaction    RC00007764
Bortezomib 387447 Drug interaction    RC00007763
Paclitaxel 36314 Drug interaction    RC00007760
5-Fluorouracil 3385 Drug interaction    RC00007756
Doxorubicin 31703 Drug interaction    RC00007759
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007755
Trastuzumab - Drug interaction    RC00007768
platinum-based doublet chemotherapy - Drug interaction    RC00007766
Marine fungal metabolite 1386A - Drug interaction    RC00007767
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1246
Panobinostat       6918837
Irinotecan       60838
Lapatinib       208908

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1246
Interactor2: ZMAT3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Downregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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