Detail Information

Basic Information:


  VIRBase ID:  

HHID00025622

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-744-5p:           MOB3C:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-744-5p MOB3C
miRBase
Accession/Entrez ID		 MIMAT0004945 148932
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MOB1E//MOBKL2C

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-744-5p
rs1178657616 chr17:12081918    A/G
rs557969425 chr17:12081909    T/A
rs557969425 chr17:12081909    T/C
rs1470408501 chr17:12081915    G/A
rs748252260 chr17:12081912    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MOB3C
chr1:47076167(-) A-I      intronic
chr1:47076153(-) A-I      intronic
chr1:47076152(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MOB3C
chr1:47073615-47073616(-) m6A 3'UTR       -
chr1:47073653-47073654(-) m6A 3'UTR       -
chr1:47073801-47073802(-) m6A 3'UTR       24284625//24981863//27773535
chr1:47073813-47073814(-) m6A 3'UTR       24284625//24981863//27773535//27371828
chr1:47073882-47073883(-) m6A 3'UTR       25456834//24981863//27773535//27371828
chr1:47073925-47073926(-) m6A 3'UTR       25456834//24981863//27773535//27371828
chr1:47073953-47073954(-) m6A 3'UTR       25456834//24981863//27773535//27371828
chr1:47073999-47074000(-) m6A 3'UTR       24981863//27773535//27371828
chr1:47074059-47074060(-) m6A 3'UTR       27773535//27371828
chr1:47074071-47074072(-) m6A 3'UTR       27773535//27371828
chr1:47074087-47074088(-) m6A 3'UTR       27773535//27371828
chr1:47074147-47074148(-) m6A 3'UTR       24284625//24981863//27773535//27371828
chr1:47074256-47074257(-) m6A 3'UTR       24284625//24981863//27773535
chr1:47074310-47074311(-) m6A 3'UTR       24284625//24981863//27773535
chr1:47074323-47074324(-) m6A 3'UTR       24284625//24981863
chr1:47074385-47074386(-) m6A 3'UTR       24284625//24981863
chr1:47075096-47075097(-) m6A 3'UTR       27773535//27371828
chr1:47075117-47075118(-) m6A 3'UTR       27773535//27371828
chr1:47075197-47075198(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr1:47075260-47075261(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:47075283-47075284(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr1:47075313-47075314(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr1:47075695-47075696(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22608085
chr1:47075857-47075858(-) m6A CDS//exon       24284625//27773535
chr1:47078625-47078626(-) m6A CDS//exon       24284625//27371828
chr1:47078740-47078741(-) m6A CDS//exon       24209618//25456834//24981863//27371828//22575960
chr1:47078796-47078797(-) m6A CDS//exon       24209618//25456834//24981863//27371828//22575960
chr1:47078829-47078830(-) m6A CDS//exon       24284625//24209618//24981863//27371828//22575960
chr1:47078865-47078866(-) m6A CDS//exon       24284625//27371828
chr1:47078958-47078959(-) m6A CDS//exon       24284625//25456834//27371828//27773536
chr1:47079017-47079018(-) m6A 5'UTR//CDS//exon       24284625//25456834//27371828//27773536
chr1:47079175-47079176(-) m6A 5'UTR//intron       25456834//27371828
chr1:47079190-47079191(-) m6A 5'UTR//intron       25456834//24981863//27371828
chr1:47079224-47079225(-) m6A 5'UTR//intron       25456834//24981863
chr1:47079247-47079248(-) m6A 5'UTR//intron       25456834//24981863
chr1:47079265-47079266(-) m6A 5'UTR//intron       25456834//24981863
chr1:47079516-47079517(-) m6A 5'UTR//intron       25456834
chr1:47079573-47079574(-) m6A 5'UTR//intron       -
chr1:47080566-47080567(-) m6A 5'UTR//intron       -
chr1:47080622-47080623(-) m6A 5'UTR//intron       -
chr1:47080697-47080698(-) m6A 5'UTR//CDS//intron       -
chr1:47080717-47080718(-) m6A 5'UTR//CDS//intron       -
chr1:47080896-47080897(-) m6A 5'UTR//intron       -
chr1:47080948-47080949(-) m1A 5'UTR//intron       26863196
chr1:47080993-47080994(-) m6A 5'UTR//intron       27773535
chr1:47081117-47081118(-) m6A 5'UTR//intron       -
chr1:47082385-47082386(-) m6A 5'UTR//exon       24209618//25456834//24981863
chr1:47082442-47082443(-) m6A 5'UTR//exon       24209618//25456834//24981863//27371828
chr1:47082456-47082457(-) m6A 5'UTR//exon       24209618//25456834//24981863//27371828
chr1:47082476-47082477(-) m6A 5'UTR//exon       24209618//25456834//24981863//27371828
chr1:47082488-47082489(-) m6A 5'UTR//exon       24209618//25456834//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-744-5p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome K562 cells     24460325
Exosome Blood|Endothelial cells     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
MOB3C
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-744-5p
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-744-5p
Carboplatinum 38904 Drug interaction    RC00007414
Paclitaxel 36314 Drug interaction    RC00007413
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007412
Tamoxifen 2733526 Drug interaction    RC00007416
Navitoclax 24978538 Drug interaction    RC00007417
Gefitinib 123631 Drug interaction    RC00007415
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-744-5p
Cisplatin 5702198       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-744-5p
Interactor2: MOB3C

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Upregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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