Detail Information

Basic Information:


  VIRBase ID:  

HHID00025557

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-744-5p:           LAMP3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-744-5p LAMP3
miRBase
Accession/Entrez ID		 MIMAT0004945 27074
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD208//DC LAMP//DC-LAMP//DCLAMP//LAMP//LAMP-3//TSC403

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-744-5p
rs1178657616 chr17:12081918    A/G
rs557969425 chr17:12081909    T/A
rs557969425 chr17:12081909    T/C
rs1470408501 chr17:12081915    G/A
rs748252260 chr17:12081912    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LAMP3
chr3:182848053(-) A-I      intronic
chr3:182846509(-) A-I      intronic
chr3:182846534(-) A-I      intronic
chr3:182848241(-) A-I      intronic
chr3:182848219(-) A-I      intronic
chr3:182864968(-) A-I      intronic
chr3:182864949(-) A-I      intronic
chr3:182864948(-) A-I      intronic
chr3:182864588(-) A-I      intronic
chr3:182864566(-) A-I      intronic
chr3:182848156(-) A-I      intronic
chr3:182867148(-) A-I      intronic
chr3:182846457(-) A-I      intronic
chr3:182864398(-) A-I      intronic
chr3:182845860(-) A-I      intronic
chr3:182845827(-) A-I      intronic
chr3:182855767(-) A-I      intronic
chr3:182865586(-) A-I      intronic
chr3:182855745(-) A-I      intronic
chr3:182855719(-) A-I      intronic
chr3:182855705(-) A-I      intronic
chr3:182855693(-) A-I      intronic
chr3:182855612(-) A-I      intronic
chr3:182844999(-) A-I      intronic
chr3:182854921(-) A-I      intronic
chr3:182854888(-) A-I      intronic
chr3:182842558(-) A-I      intronic
chr3:182842533(-) A-I      intronic
chr3:182865701(-) A-I      intronic
chr3:182848111(-) A-I      intronic
chr3:182855752(-) A-I      intronic
chr3:182841103(-) A-I      3'UTR
chr3:182841102(-) A-I      3'UTR
chr3:182841084(-) A-I      3'UTR
chr3:182841117(-) A-I      3'UTR
chr3:182841112(-) A-I      3'UTR
chr3:182841090(-) A-I      3'UTR
chr3:182841104(-) A-I      3'UTR
chr3:182845142(-) A-I      intronic
chr3:182846523(-) A-I      intronic
chr3:182845045(-) A-I      intronic
chr3:182845752(-) A-I      intronic
chr3:182845755(-) A-I      intronic
chr3:182864842(-) A-I      intronic
chr3:182865665(-) A-I      intronic
chr3:182851343(-) A-I      intronic
chr3:182848115(-) A-I      intronic
chr3:182845730(-) A-I      intronic
chr3:182857059(-) A-I      intronic
chr3:182865778(-) A-I      intronic
chr3:182874000(-) A-I      intronic
chr3:182847948(-) A-I      intronic
chr3:182845089(-) A-I      intronic
chr3:182845824(-) A-I      intronic
chr3:182846605(-) A-I      intronic
chr3:182844995(-) A-I      intronic
chr3:182841325(-) A-I      3'UTR
chr3:182841235(-) A-I      3'UTR
chr3:182845675(-) A-I      intronic
chr3:182846609(-) A-I      intronic
chr3:182865594(-) A-I      intronic
chr3:182846596(-) A-I      intronic
chr3:182844953(-) A-I      intronic
chr3:182857102(-) A-I      intronic
chr3:182846533(-) A-I      intronic
chr3:182842464(-) A-I      intronic
chr3:182855704(-) A-I      intronic
chr3:182851215(-) A-I      intronic
chr3:182844952(-) A-I      intronic
chr3:182855812(-) A-I      intronic
chr3:182855884(-) A-I      intronic
chr3:182845204(-) A-I      intronic
chr3:182845814(-) A-I      intronic
chr3:182851281(-) A-I      intronic
chr3:182848085(-) A-I      intronic
chr3:182845050(-) A-I      intronic
chr3:182845119(-) A-I      intronic
chr3:182865760(-) A-I      intronic
chr3:182862626(-) A-I      intronic
chr3:182846468(-) A-I      intronic
chr3:182846597(-) A-I      intronic
chr3:182855806(-) A-I      intronic
chr3:182842498(-) A-I      intronic
chr3:182864989(-) A-I      intronic
chr3:182857066(-) A-I      intronic
chr3:182845194(-) A-I      intronic
chr3:182845738(-) A-I      intronic
chr3:182846497(-) A-I      intronic
chr3:182846602(-) A-I      intronic
chr3:182846557(-) A-I      intronic
chr3:182851280(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LAMP3
chr3:182844953(-) A-I intron -    22327324
chr3:182845194(-) A-I intron -    22327324
chr3:182845685(-) A-I intron -    22327324
chr3:182846533(-) A-I intron -    22327324
chr3:182846605(-) A-I intron -    22327324
chr3:182846609(-) A-I intron -    22327324
chr3:182844744(-) A-G intron -    22484847
chr3:182841207(-) G-A exon 3'UTR    22484847
chr3:182842464(-) A-G intron -    22484847
chr3:182842498(-) A-G intron -    22484847
chr3:182844952(-) A-G intron -    22484847
chr3:182844953(-) A-G intron -    22484847
chr3:182844995(-) A-G intron -    22484847
chr3:182845045(-) A-G intron -    22484847
chr3:182845050(-) A-G intron -    22484847
chr3:182845089(-) A-G intron -    22484847
chr3:182845119(-) A-G intron -    22484847
chr3:182845141(-) A-G intron -    22484847
chr3:182845142(-) A-G intron -    22484847
chr3:182845150(-) A-G intron -    22484847
chr3:182845194(-) A-G intron -    22484847
chr3:182845204(-) A-G intron -    22484847
chr3:182845675(-) A-G intron -    22484847
chr3:182845730(-) A-G intron -    22484847
chr3:182845738(-) A-G intron -    22484847
chr3:182845752(-) A-G intron -    22484847
chr3:182845755(-) A-G intron -    22484847
chr3:182845814(-) A-G intron -    22484847
chr3:182845824(-) A-G intron -    22484847
chr3:182845935(-) G-T intron -    22484847
chr3:182846468(-) A-G intron -    22484847
chr3:182846494(-) A-G intron -    22484847
chr3:182846497(-) A-G intron -    22484847
chr3:182846523(-) A-G intron -    22484847
chr3:182846533(-) A-G intron -    22484847
chr3:182846557(-) A-G intron -    22484847
chr3:182846596(-) A-G intron -    22484847
chr3:182846597(-) A-G intron -    22484847
chr3:182846602(-) A-G intron -    22484847
chr3:182846605(-) A-G intron -    22484847
chr3:182846609(-) A-G intron -    22484847
chr3:182846820(-) T-C intron -    22484847
chr3:182848075(-) A-G intron -    22484847
chr3:182848085(-) A-G intron -    22484847
chr3:182851281(-) A-G intron -    22484847
chr3:182851343(-) A-G intron -    22484847
chr3:182851395(-) A-G intron -    22484847
chr3:182855675(-) A-G intron -    22484847
chr3:182855704(-) A-G intron -    22484847
chr3:182855806(-) A-G intron -    22484847
chr3:182855807(-) A-G intron -    22484847
chr3:182855812(-) A-G intron -    22484847
chr3:182856933(-) A-G intron -    22484847
chr3:182856960(-) A-G intron -    22484847
chr3:182857066(-) A-G intron -    22484847
chr3:182857102(-) A-G intron -    22484847
chr3:182864842(-) A-G intron -    22484847
chr3:182864931(-) A-G intron -    22484847
chr3:182864987(-) A-G intron -    22484847
chr3:182864989(-) A-G intron -    22484847
chr3:182865594(-) A-G intron -    22484847
chr3:182865665(-) A-G intron -    22484847
chr3:182865704(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LAMP3
chr3:182871523-182871524(-) m6A CDS       27773535//27371828
chr3:182871555-182871556(-) m6A CDS       28052920//27773535//27371828
chr3:182871648-182871649(-) m6A CDS       24209618//24981863//28052920//27773535//27371828
chr3:182871732-182871733(-) m6A CDS       24209618//24981863//28052920//27773535
chr3:182871755-182871756(-) m6A CDS       24209618//24981863//28052920//27773535
chr3:182871789-182871790(-) m6A CDS       24209618//24981863//28052920//27773535
chr3:182871950-182871951(-) m6A CDS       24209618//28052920//27773535
chr3:182871999-182872000(-) m6A CDS       24209618//28052920//27773535
chr3:182872041-182872042(-) m6A CDS       28052920//27773535
chr3:182872078-182872079(-) m6A CDS       28052920//27773535
chr3:182872088-182872089(-) m6A CDS       28052920//27773535
chr3:182872131-182872132(-) m6A CDS       27371828
chr3:182878651-182878652(-) m6A 5'UTR//exon//intron       27371828
chr3:182878711-182878712(-) m6A 5'UTR//exon//intron       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-744-5p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome K562 cells     24460325
Exosome Blood|Endothelial cells     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
LAMP3
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-744-5p
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-744-5p
Carboplatinum 38904 Drug interaction    RC00007414
Paclitaxel 36314 Drug interaction    RC00007413
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007412
Tamoxifen 2733526 Drug interaction    RC00007416
Navitoclax 24978538 Drug interaction    RC00007417
Gefitinib 123631 Drug interaction    RC00007415
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-744-5p
Cisplatin 5702198       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-744-5p
Interactor2: LAMP3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Upregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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