Basic Information:

  VIRBase ID:  

HHID00025384

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-654-3p:  MIMAT0004814          TRIM56:  NM_030961     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-654-3p	TRIM56
miRBase Accession/Entrez ID	MIMAT0004814	81844
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RNF109

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-654-3p	rs1236276147 chr14:101040288    C/T rs1273890232 chr14:101040280    ACCATCACCTTTAGAAGC/A rs1345261848 chr14:101040286    A/G rs1421723544 chr14:101040280    A/G rs1337045937 chr14:101040272    G/A rs1410951502 chr14:101040270    A/G rs371699284 chr14:101040271    T/C rs764342883 chr14:101040276    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRIM56	chr7:100733648(+) A-I      3'UTR chr7:100733758(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRIM56	chr7:100733648(+) A-G intron -    22484847 chr7:100733758(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIM56	chr7:100730090-100730091(+) m6A 5'UTR//intron       24284625//24981863 chr7:100730171-100730172(+) m6A 5'UTR//intron       24284625 chr7:100730228-100730229(+) m6A 5'UTR//intron       24284625//24981863 chr7:100730235-100730236(+) m6A 5'UTR//intron       24284625//24981863 chr7:100730269-100730270(+) m6A 5'UTR//intron       24284625//24981863 chr7:100730422-100730423(+) m6A 5'UTR       24284625//24209618 chr7:100730689-100730690(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100730720-100730721(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100730776-100730777(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100730815-100730816(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100730843-100730844(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100730870-100730871(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100730957-100730958(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731013-100731014(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731035-100731036(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731176-100731177(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731188-100731189(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731246-100731247(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731263-100731264(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731349-100731350(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731449-100731450(+) m1A CDS//intron       26863196 chr7:100731671-100731672(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731677-100731678(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100731796-100731797(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:100731804-100731805(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:100731844-100731845(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:100731868-100731869(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:100731892-100731893(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:100731905-100731906(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:100731916-100731917(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:100731936-100731937(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:100731960-100731961(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:100732062-100732063(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:100732103-100732104(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr7:100732175-100732176(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr7:100732394-100732395(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr7:100732547-100732548(+) m6A CDS//intron       24284625//24209618//25456834//24981863 chr7:100732709-100732710(+) m6A CDS//intron       24284625//24209618 chr7:100732733-100732734(+) m6A CDS//intron       24284625//24209618 chr7:100732822-100732823(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr7:100732853-100732854(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr7:100732871-100732872(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960 chr7:100732945-100732946(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863 chr7:100732995-100732996(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863 chr7:100733030-100733031(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863 chr7:100733206-100733207(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr7:100733285-100733286(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr7:100733296-100733297(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr7:100733313-100733314(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr7:100733466-100733467(+) m6A 3'UTR//exon//intron       24284625 chr7:100734258-100734259(+) m6A 3'UTR//intron       - chr7:100734266-100734267(+) m6A 3'UTR//intron       - chr7:100734285-100734286(+) m6A 3'UTR//intron       - chr7:100734304-100734305(+) m6A 3'UTR//intron       - chr7:100734346-100734347(+) m6A 3'UTR//intron       - chr7:100734360-100734361(+) m6A 3'UTR//intron       - chr7:100734389-100734390(+) m6A 3'UTR//intron       - chr7:100734498-100734499(+) m6A 3'UTR//intron       - chr7:100734505-100734506(+) m6A 3'UTR//intron       - chr7:100734525-100734526(+) m6A 3'UTR//intron       - chr7:100734541-100734542(+) m6A 3'UTR//intron       - chr7:100734603-100734604(+) m6A 3'UTR//intron       - chr7:100734623-100734624(+) m6A 3'UTR//intron       - chr7:100734633-100734634(+) m6A 3'UTR//intron       - chr7:100734654-100734655(+) m6A 3'UTR//intron       - chr7:100734719-100734720(+) m6A 3'UTR//intron       - chr7:100734928-100734929(+) m6A 3'UTR//CDS       24981863 chr7:100734998-100734999(+) m6A 3'UTR//CDS       24981863 chr7:100735036-100735037(+) m6A 3'UTR       - chr7:100735129-100735130(+) m6A 3'UTR       - chr7:100736594-100736595(+) m6A 3'UTR       - chr7:100736644-100736645(+) m6A 3'UTR       - chr7:100736661-100736662(+) m6A 3'UTR       - chr7:100736720-100736721(+) m6A 3'UTR       - chr7:100736738-100736739(+) m6A 3'UTR       - chr7:100736782-100736783(+) m6A 3'UTR       - chr7:100737343-100737344(+) m6A 3'UTR       24284625//24981863 chr7:100737377-100737378(+) m6A 3'UTR       24284625//24981863 chr7:100737384-100737385(+) m6A 3'UTR       24284625//24981863 chr7:100737467-100737468(+) m6A 3'UTR       24284625//27773535 chr7:100737559-100737560(+) m6A 3'UTR       24981863//27773535 chr7:100738037-100738038(+) m6A 3'UTR       - chr7:100738048-100738049(+) m6A 3'UTR       - chr7:100738069-100738070(+) m6A 3'UTR       - chr7:100738307-100738308(+) m6A 3'UTR       24284625 chr7:100738369-100738370(+) m6A 3'UTR       24284625 chr7:100738644-100738645(+) m6A 3'UTR       24284625 chr7:100738729-100738730(+) m6A 3'UTR       24284625 chr7:100738767-100738768(+) m6A 3'UTR       - chr7:100738857-100738858(+) m6A 3'UTR       - chr7:100738866-100738867(+) m6A 3'UTR       - chr7:100739040-100739041(+) m6A 3'UTR       24981863//27773535 chr7:100739131-100739132(+) m6A 3'UTR       - chr7:100739155-100739156(+) m6A 3'UTR       24209618 chr7:100739195-100739196(+) m6A 3'UTR       24209618 chr7:100739202-100739203(+) m6A 3'UTR       24209618 chr7:100739292-100739293(+) m6A 3'UTR       24981863 chr7:100739459-100739460(+) m6A 3'UTR       - chr7:100740444-100740445(+) m6A 3'UTR       - chr7:100740481-100740482(+) m6A 3'UTR       - chr7:100740539-100740540(+) m6A 3'UTR       24981863 chr7:100740586-100740587(+) m6A 3'UTR       24981863 chr7:100740617-100740618(+) m6A 3'UTR       24981863 chr7:100740630-100740631(+) m6A 3'UTR       24981863//27773535 chr7:100740675-100740676(+) m6A 3'UTR       24981863//27773535 chr7:100740692-100740693(+) m6A 3'UTR       24981863//27773535 chr7:100740734-100740735(+) m6A 3'UTR       24209618//24981863//27773535 chr7:100740778-100740779(+) m6A 3'UTR       24209618//24981863//27773535 chr7:100740805-100740806(+) m6A 3'UTR       24209618//24981863//27773535 chr7:100740812-100740813(+) m6A 3'UTR       24209618//24981863//27773535 chr7:100740854-100740855(+) m6A 3'UTR       24981863//27773535 chr7:100740894-100740895(+) m6A 3'UTR       24981863//27773535 chr7:100740923-100740924(+) m6A 3'UTR       25456834//24981863//22608085 chr7:100740978-100740979(+) m6A 3'UTR       25456834//24981863//22608085 chr7:100741002-100741003(+) m6A 3'UTR       25456834//24981863//22608085 chr7:100741090-100741091(+) m6A 3'UTR       25456834//24981863 chr7:100741106-100741107(+) m6A 3'UTR       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-654-3p	Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TRIM56	Exosome Blood     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-654-3p	D-Glucose 5793 Drug interaction    RC00007238 Vorinostat 5311 Drug interaction    RC00007237

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-654-3p	Topotecan       60700 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-654-3p
Interactor2: TRIM56

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).