Detail Information

Basic Information:


  VIRBase ID:  

HHID00025325

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-654-3p:           KLF4:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-654-3p KLF4
miRBase
Accession/Entrez ID		 MIMAT0004814 9314
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EZF//GKLF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-654-3p
rs1236276147 chr14:101040288    C/T
rs1273890232 chr14:101040280    ACCATCACCTTTAGAAGC/A
rs1345261848 chr14:101040286    A/G
rs1421723544 chr14:101040280    A/G
rs1337045937 chr14:101040272    G/A
rs1410951502 chr14:101040270    A/G
rs371699284 chr14:101040271    T/C
rs764342883 chr14:101040276    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KLF4
chr9:110247697-110247698(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085
chr9:110247776-110247777(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr9:110247841-110247842(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr9:110247855-110247856(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr9:110248023-110248024(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085
chr9:110248065-110248066(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr9:110248124-110248125(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085
chr9:110248145-110248146(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085
chr9:110248199-110248200(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr9:110249317-110249318(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr9:110249356-110249357(-) m6A CDS//exon       24284625//24981863//27773535//22575960
chr9:110249395-110249396(-) m6A CDS//exon       24284625//24981863//27773535
chr9:110249512-110249513(-) m6A exon//intron       24284625//24981863//27773535
chr9:110249688-110249689(-) m6A CDS//exon//intron       24284625//25456834//24981863//27773535
chr9:110249731-110249732(-) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//27773536
chr9:110249801-110249802(-) m6A CDS//exon//intron       24284625//24981863//27371828//27773536
chr9:110250048-110250049(-) m6A CDS//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr9:110250108-110250109(-) m6A CDS//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960
chr9:110250357-110250358(-) m6A CDS//exon//intron       24284625//24981863
chr9:110250363-110250364(-) m6A CDS//exon//intron       24284625//24981863
chr9:110250388-110250389(-) m6A CDS//exon//intron       24284625//24981863
chr9:110250456-110250457(-) m6A CDS//exon//intron       24284625//24981863
chr9:110250585-110250586(-) m6A exon//intron       24284625
chr9:110251239-110251240(-) m6A CDS//exon       24284625
chr9:110251406-110251407(-) m6A 5'UTR//intron       24284625//27773535
chr9:110251473-110251474(-) m6A 5'UTR//exon       24284625//27773535
chr9:110251616-110251617(-) m6A 5'UTR//exon       24284625//24981863//27773535
chr9:110251634-110251635(-) m6A 5'UTR//exon       24284625//24981863//27773535
chr9:110251689-110251690(-) m6A 5'UTR//exon       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-654-3p
Exosome Plasma     23663360
Exosome Endothelial cells     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
KLF4
Cytoplasm NSCLC tissue     29665649
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus NSCLC tissue     29665649
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-654-3p
D-Glucose 5793 Drug interaction    RC00007238
Vorinostat 5311 Drug interaction    RC00007237
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-654-3p
Topotecan       60700
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-654-3p
Interactor2: KLF4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Upregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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