Basic Information:

  VIRBase ID:  

HHID00025298

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-654-3p:  MIMAT0004814          CXCL11:  NM_001302123     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-654-3p	CXCL11
miRBase Accession/Entrez ID	MIMAT0004814	6373
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	b-R1//H174//I-TAC//IP-9//IP9//SCYB11//SCYB9B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-654-3p	rs1236276147 chr14:101040288    C/T rs1273890232 chr14:101040280    ACCATCACCTTTAGAAGC/A rs1345261848 chr14:101040286    A/G rs1421723544 chr14:101040280    A/G rs1337045937 chr14:101040272    G/A rs1410951502 chr14:101040270    A/G rs371699284 chr14:101040271    T/C rs764342883 chr14:101040276    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CXCL11	chr4:76955765-76955766(-) m6A 3'UTR       27773535 chr4:76955772-76955773(-) m6A 3'UTR       27773535 chr4:76955840-76955841(-) m6A 3'UTR       27773535 chr4:76955846-76955847(-) m6A 3'UTR       27773535 chr4:76955894-76955895(-) m6A 3'UTR       27773535 chr4:76955901-76955902(-) m6A 3'UTR       27773535 chr4:76955934-76955935(-) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-654-3p	Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CXCL11	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-654-3p	D-Glucose 5793 Drug interaction    RC00007238 Vorinostat 5311 Drug interaction    RC00007237

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-654-3p	Topotecan       60700 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-654-3p
Interactor2: CXCL11

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).