Basic Information:

  VIRBase ID:  

HHID00025180

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-411-3p:  MIMAT0004813          ZCCHC2:  NM_017742     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-411-3p	ZCCHC2
miRBase Accession/Entrez ID	MIMAT0004813	54877
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C18orf49

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-411-3p	rs1437940946 chr14:101023393    A/G rs200209446 chr14:101023384    C/T rs368977912 chr14:101023392    T/G rs566979073 chr14:101023391    C/T rs748033801 chr14:101023385    G/A rs759656399 chr14:101023395    C/A rs772106334 chr14:101023390    A/T rs111835650 chr14:101023377    T/C rs1285882332 chr14:101023382    C/A rs1353902015 chr14:101023380    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZCCHC2	chr18:60214280(+) A-I      intronic chr18:60214894(+) A-I      intronic chr18:60214302(+) A-I      intronic chr18:60214372(+) A-I      intronic chr18:60214995(+) A-I      intronic chr18:60214934(+) A-I      intronic chr18:60214921(+) A-I      intronic chr18:60215004(+) A-I      intronic chr18:60214382(+) A-I      intronic chr18:60214393(+) A-I      intronic chr18:60215033(+) A-I      intronic chr18:60229426(+) A-I      intronic chr18:60214473(+) A-I      intronic chr18:60214548(+) A-I      intronic chr18:60222801(+) A-I      intronic chr18:60220033(+) A-I      intronic chr18:60229356(+) A-I      intronic chr18:60200837(+) A-I      intronic chr18:60214416(+) A-I      intronic chr18:60204627(+) A-I      intronic chr18:60216197(+) A-I      intronic chr18:60204511(+) A-I      intronic chr18:60201025(+) A-I      intronic chr18:60201454(+) A-I      intronic chr18:60214895(+) A-I      intronic chr18:60204461(+) A-I      intronic chr18:60204651(+) A-I      intronic chr18:60204538(+) A-I      intronic chr18:60215016(+) A-I      intronic chr18:60215965(+) A-I      intronic chr18:60214912(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZCCHC2	chr18:60244998(+) A-I intron -    21960545 chr18:60209797(+) A-C exon CDS    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZCCHC2	chr18:60190300-60190301(+) m6A 5'UTR       25456834//24981863 chr18:60190362-60190363(+) m6A 5'UTR       24284625//25456834//24981863 chr18:60190405-60190406(+) m6A 5'UTR       24284625//25456834//24981863 chr18:60190516-60190517(+) m6A 5'UTR       24209618 chr18:60190854-60190855(+) m6A CDS       - chr18:60191015-60191016(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191063-60191064(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191078-60191079(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191126-60191127(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191207-60191208(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191252-60191253(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr18:60191430-60191431(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191502-60191503(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60191620-60191621(+) m6A CDS//intron       24284625//25456834//24981863//22575960//22608085 chr18:60191805-60191806(+) m6A CDS//intron       24284625//24209618 chr18:60191976-60191977(+) m6A CDS//intron       25456834 chr18:60192136-60192137(+) m6A 3'UTR//intron       24209618 chr18:60192222-60192223(+) m6A 3'UTR//intron       24284625//24209618 chr18:60192237-60192238(+) m6A 3'UTR//intron       24284625//24209618 chr18:60241363-60241364(+) m6A CDS//exon       22608085 chr18:60241418-60241419(+) m6A CDS//exon       22608085 chr18:60241439-60241440(+) m6A CDS//exon       22608085 chr18:60241536-60241537(+) m6A CDS//exon       22608085 chr18:60241552-60241553(+) m6A CDS//exon       22608085 chr18:60241847-60241848(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr18:60241910-60241911(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60241944-60241945(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60241976-60241977(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60241984-60241985(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242108-60242109(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242294-60242295(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242311-60242312(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242380-60242381(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242390-60242391(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242433-60242434(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242519-60242520(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242545-60242546(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242562-60242563(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242733-60242734(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60242747-60242748(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:60243754-60243755(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:60243807-60243808(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:60244496-60244497(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244506-60244507(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244533-60244534(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244552-60244553(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244601-60244602(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244612-60244613(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr18:60244708-60244709(+) m6A 3'UTR//intron       24284625 chr18:60245376-60245377(+) m6A 3'UTR//intron       24981863 chr18:60252239-60252240(+) m6A 3'UTR//exon//intron       - chr18:60252254-60252255(+) m6A 3'UTR//exon//intron       - chr18:60252277-60252278(+) m6A 3'UTR//exon//intron       - chr18:60252377-60252378(+) m6A 3'UTR//exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-411-3p	Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
	ZCCHC2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-411-3p
Interactor2: ZCCHC2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).