Detail Information

Basic Information:


  VIRBase ID:  

HHID00025139

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-411-3p:           TRIM25:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-411-3p TRIM25
miRBase
Accession/Entrez ID		 MIMAT0004813 7706
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EFP//RNF147//Z147//ZNF147

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-411-3p
rs1437940946 chr14:101023393    A/G
rs200209446 chr14:101023384    C/T
rs368977912 chr14:101023392    T/G
rs566979073 chr14:101023391    C/T
rs748033801 chr14:101023385    G/A
rs759656399 chr14:101023395    C/A
rs772106334 chr14:101023390    A/T
rs111835650 chr14:101023377    T/C
rs1285882332 chr14:101023382    C/A
rs1353902015 chr14:101023380    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM25
chr17:54983917(-) A-I      intronic
chr17:54983310(-) A-I      intronic
chr17:54984137(-) A-I      intronic
chr17:54982581(-) A-I      intronic
chr17:54984144(-) A-I      intronic
chr17:54983127(-) A-I      intronic
chr17:54990368(-) A-I      intronic
chr17:54983238(-) A-I      intronic
chr17:54983262(-) A-I      intronic
chr17:54983101(-) A-I      intronic
chr17:54982662(-) A-I      intronic
chr17:54983993(-) A-I      intronic
chr17:54983951(-) A-I      intronic
chr17:54982577(-) A-I      intronic
chr17:54984059(-) A-I      intronic
chr17:54982601(-) A-I      intronic
chr17:54983995(-) A-I      intronic
chr17:54982585(-) A-I      intronic
chr17:54965860(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRIM25
chr17:54973875(-) C-T intron -    22484847
chr17:54982577(-) A-G intron -    22484847
chr17:54965860(-) A-G exon 3'UTR    22484847
chr17:54990654(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM25
chr17:54965284-54965285(-) m6A 3'UTR       28052920//27773535//22608085
chr17:54965340-54965341(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//22608085
chr17:54965350-54965351(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//22608085
chr17:54965456-54965457(-) m6A 3'UTR       24284625//24981863//28052920//22608085
chr17:54965463-54965464(-) m6A 3'UTR       24284625//24981863//28052920//22608085
chr17:54965475-54965476(-) m6A 3'UTR       24284625//24981863//28052920//22608085
chr17:54965528-54965529(-) m6A 3'UTR       24284625//24981863//22608085
chr17:54965590-54965591(-) m6A 3'UTR       24284625//24981863//22608085
chr17:54966028-54966029(-) m6A 3'UTR       -
chr17:54966062-54966063(-) m6A 3'UTR       -
chr17:54967981-54967982(-) m6A 3'UTR//exon       24284625
chr17:54968194-54968195(-) m6A 3'UTR//exon       24284625//24981863//22575960
chr17:54968394-54968395(-) m6A 3'UTR//exon       24284625
chr17:54968401-54968402(-) m6A 3'UTR//exon       24284625
chr17:54968499-54968500(-) m6A 3'UTR//exon       24284625//24981863
chr17:54968524-54968525(-) m6A 3'UTR//exon       24284625//24981863
chr17:54968581-54968582(-) m6A 3'UTR//exon       24284625
chr17:54968989-54968990(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr17:54969015-54969016(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr17:54969136-54969137(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22575960
chr17:54969251-54969252(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:54969352-54969353(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:54969391-54969392(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:54969493-54969494(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:54969568-54969569(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:54972719-54972720(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535
chr17:54972739-54972740(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535
chr17:54972771-54972772(-) m6A 3'UTR//CDS//exon       24284625//24209618//27773535
chr17:54972897-54972898(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535
chr17:54972915-54972916(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535
chr17:54973248-54973249(-) m6A exon//intron       24981863
chr17:54973290-54973291(-) m6A 3'UTR//CDS//exon       24981863
chr17:54976371-54976372(-) m6A exon//intron       24981863
chr17:54978838-54978839(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828
chr17:54978877-54978878(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54978882-54978883(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54978927-54978928(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54981654-54981655(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54981674-54981675(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54981773-54981774(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//27371828
chr17:54981838-54981839(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54985847-54985848(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54985906-54985907(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54989481-54989482(-) m6A CDS//intron       27371828
chr17:54989506-54989507(-) m6A CDS//intron       27371828
chr17:54989511-54989512(-) m6A CDS//intron       27371828
chr17:54990924-54990925(-) m6A CDS       24284625
chr17:54991152-54991153(-) m6A CDS       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-411-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
TRIM25
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-411-3p
Interactor2: TRIM25

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Upregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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