Basic Information:

  VIRBase ID:  

HHID00025076

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-330-5p:  MIMAT0004693          SLC9C1:  NM_183061     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-330-5p	SLC9C1
miRBase Accession/Entrez ID	MIMAT0004693	285335
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NHE//NHE-10//SLC9A10//sperm-NHE

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-330-5p	rs1349824380 chr19:45639070    A/G rs1359949384 chr19:45639062    G/A rs760888385 chr19:45639051    C/G rs761051145 chr19:45639055    GAC/G rs1450351295 chr19:45639066    A/T rs562108564 chr19:45639069    G/T rs768769902 chr19:45639068    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC9C1	chr3:111986026(-) A-I      intronic chr3:111985957(-) A-I      intronic chr3:111985953(-) A-I      intronic chr3:111985928(-) A-I      intronic chr3:111986210(-) A-I      intronic chr3:112002324(-) A-I      intronic chr3:111986017(-) A-I      intronic chr3:111986018(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC9C1	chr3:111986017(-) A-G intron -    22484847 chr3:111986018(-) A-G intron -    22484847

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-330-5p	Exosome HCC tissues     30542726 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	SLC9C1	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-330-5p	D-Glucose 5793 Drug interaction    RC00007082 Mistletoe lectin-I - Drug interaction    RC00007083

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-330-5p	Etoposide 36462       23028896

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-330-5p
Interactor2: SLC9C1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).