Basic Information:

  VIRBase ID:  

HHID00025065

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-330-5p:  MIMAT0004693          DTX3L:  NM_138287     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-330-5p	DTX3L
miRBase Accession/Entrez ID	MIMAT0004693	151636
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BBAP//RNF143

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-330-5p	rs1349824380 chr19:45639070    A/G rs1359949384 chr19:45639062    G/A rs760888385 chr19:45639051    C/G rs761051145 chr19:45639055    GAC/G rs1450351295 chr19:45639066    A/T rs562108564 chr19:45639069    G/T rs768769902 chr19:45639068    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DTX3L	chr3:122290216(+) A-I      intronic chr3:122290199(+) A-I      intronic chr3:122290184(+) A-I      intronic chr3:122286883(+) A-I      intronic chr3:122286937(+) A-I      intronic chr3:122285326(+) A-I      intronic chr3:122285353(+) A-I      intronic chr3:122285250(+) A-I      intronic chr3:122287009(+) A-I      intronic chr3:122286992(+) A-I      intronic chr3:122286997(+) A-I      intronic chr3:122290873(+) A-I      3'UTR chr3:122290836(+) A-I      3'UTR chr3:122290868(+) A-I      3'UTR chr3:122291450(+) A-I      3'UTR chr3:122287152(+) A-I      intronic chr3:122285237(+) A-I      intronic chr3:122285444(+) A-I      intronic chr3:122285275(+) A-I      intronic chr3:122287121(+) A-I      intronic chr3:122286980(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DTX3L	chr3:122288403(+) A-I exon CDS    15342557 chr3:122290223(+) A-I intron -    15342557   //22327324 chr3:122290238(+) A-I intron -    15342557   //22327324 chr3:122290836(+) A-I exon 3'UTR    15342557 chr3:122290849(+) A-I exon 3'UTR    15342557 chr3:122290868(+) A-I exon 3'UTR    15342557 chr3:122290873(+) A-I exon 3'UTR    15342557 chr3:122291012(+) A-I exon 3'UTR    15342557 chr3:122292342(+) A-I exon 3'UTR    15342557 chr3:122289727(+) A-I intron -    21960545   //22327324 chr3:122290237(+) A-I intron -    21960545 chr3:122285267(+) A-G intron -    22484847 chr3:122285275(+) A-G intron -    22484847 chr3:122285396(+) A-G intron -    22484847 chr3:122285399(+) A-G intron -    22484847 chr3:122285444(+) A-G intron -    22484847 chr3:122286992(+) A-G intron -    22484847 chr3:122286997(+) A-G intron -    22484847 chr3:122290765(+) T-C intron -    22484847 chr3:122291466(+) C-T intron -    22484847 chr3:122292945(+) A-T intron -    22484847 chr3:122290223(+) A-G intron -    22484847 chr3:122290238(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DTX3L	chr3:122283117-122283118(+) m6A 5'UTR       25456834 chr3:122283154-122283155(+) m6A 5'UTR       25456834//24981863 chr3:122283164-122283165(+) m6A 5'UTR       25456834//24981863 chr3:122283181-122283182(+) m6A 5'UTR       25456834//24981863 chr3:122283187-122283188(+) m6A 5'UTR       25456834//24981863 chr3:122283413-122283414(+) m6A CDS       24981863 chr3:122284757-122284758(+) m6A CDS       - chr3:122287474-122287475(+) m6A CDS//intron       24981863 chr3:122287529-122287530(+) m6A CDS//intron       24981863//22608085 chr3:122287585-122287586(+) m6A CDS//intron       24981863//22608085 chr3:122287607-122287608(+) m6A CDS//intron       24981863//22608085 chr3:122287614-122287615(+) m6A CDS//intron       24981863 chr3:122287625-122287626(+) m6A CDS//intron       24981863 chr3:122287876-122287877(+) m6A CDS//intron       24284625 chr3:122287901-122287902(+) m6A CDS//intron       24284625//24981863 chr3:122287971-122287972(+) m6A CDS//intron       24284625//24981863//22608085 chr3:122287997-122287998(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr3:122288036-122288037(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr3:122288093-122288094(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr3:122288103-122288104(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr3:122288181-122288182(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr3:122288206-122288207(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr3:122288337-122288338(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr3:122288366-122288367(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr3:122288511-122288512(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:122288521-122288522(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:122288591-122288592(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:122288596-122288597(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:122288632-122288633(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:122288736-122288737(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr3:122288800-122288801(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr3:122288868-122288869(+) m6A CDS//intron       24284625//24209618//24981863//27773535 chr3:122289306-122289307(+) m6A CDS       24284625//24209618//24981863//27773535 chr3:122289314-122289315(+) m6A CDS       24284625//24209618//24981863//27773535 chr3:122289346-122289347(+) m6A CDS       24284625//24981863//27773535 chr3:122289390-122289391(+) m6A CDS       24284625//24981863//27773535 chr3:122289493-122289494(+) m6A CDS       24209618 chr3:122289510-122289511(+) m6A CDS       24209618 chr3:122290687-122290688(+) m6A 3'UTR       24981863 chr3:122292820-122292821(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-330-5p	Exosome HCC tissues     30542726 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	DTX3L	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-330-5p	D-Glucose 5793 Drug interaction    RC00007082 Mistletoe lectin-I - Drug interaction    RC00007083

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-330-5p	Etoposide 36462       23028896

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-330-5p
Interactor2: DTX3L

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).