Basic Information:

  VIRBase ID:  

HHID00025050

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-330-5p:  MIMAT0004693          BATF2:  NM_138456     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-330-5p	BATF2
miRBase Accession/Entrez ID	MIMAT0004693	116071
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SARI

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-330-5p	rs1349824380 chr19:45639070    A/G rs1359949384 chr19:45639062    G/A rs760888385 chr19:45639051    C/G rs761051145 chr19:45639055    GAC/G rs1450351295 chr19:45639066    A/T rs562108564 chr19:45639069    G/T rs768769902 chr19:45639068    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BATF2	chr11:64761469(-) A-I      intronic chr11:64758360(-) A-I      intronic chr11:64760205(-) A-I      intronic chr11:64758359(-) A-I      intronic chr11:64760216(-) A-I      intronic chr11:64760266(-) A-I      intronic chr11:64761383(-) A-I      intronic chr11:64761406(-) A-I      intronic chr11:64761543(-) A-I      intronic chr11:64761392(-) A-I      intronic chr11:64760211(-) A-I      intronic chr11:64760302(-) A-I      intronic chr11:64761388(-) A-I      intronic chr11:64760076(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BATF2	chr11:64755543-64755544(-) m6A 3'UTR//exon       27773535 chr11:64755574-64755575(-) m6A 3'UTR//exon       25456834//27773535 chr11:64755669-64755670(-) m6A 3'UTR//exon       25456834 chr11:64755703-64755704(-) m6A 3'UTR//exon       25456834 chr11:64755822-64755823(-) m6A 3'UTR//exon       27773535 chr11:64756125-64756126(-) m6A 3'UTR//exon       27371828 chr11:64756930-64756931(-) m6A CDS//exon       24981863//27371828 chr11:64757049-64757050(-) m6A CDS//exon       24981863//27371828//27773536 chr11:64757086-64757087(-) m6A CDS//exon       25456834//27371828//27773536 chr11:64757123-64757124(-) m6A CDS//exon       25456834//27371828//27773536 chr11:64757199-64757200(-) m6A 5'UTR//CDS//exon       25456834//27371828 chr11:64757261-64757262(-) m6A 5'UTR//CDS//exon       27371828//27773536 chr11:64757363-64757364(-) m6A exon//intron       27371828 chr11:64757414-64757415(-) m6A exon//intron       - chr11:64757967-64757968(-) m6A exon//intron       27371828 chr11:64761941-64761942(-) m6A CDS       27371828 chr11:64761980-64761981(-) m6A CDS       25456834//27371828 chr11:64764349-64764350(-) m6A CDS       25456834//27371828 chr11:64764410-64764411(-) m6A 5'UTR       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-330-5p	Exosome HCC tissues     30542726 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	BATF2	Chromatin K562 cells     - Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-330-5p	D-Glucose 5793 Drug interaction    RC00007082 Mistletoe lectin-I - Drug interaction    RC00007083

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-330-5p	Etoposide 36462       23028896

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-330-5p
Interactor2: BATF2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).