Detail Information

Basic Information:


  VIRBase ID:  

HHID00025034

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-330-5p:           UNC93B1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-330-5p UNC93B1
miRBase
Accession/Entrez ID		 MIMAT0004693 81622
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IIAE1//Unc-93B1//UNC93//UNC93B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-330-5p
rs1349824380 chr19:45639070    A/G
rs1359949384 chr19:45639062    G/A
rs760888385 chr19:45639051    C/G
rs761051145 chr19:45639055    GAC/G
rs1450351295 chr19:45639066    A/T
rs562108564 chr19:45639069    G/T
rs768769902 chr19:45639068    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UNC93B1
chr11:67760135(-) A-I      intronic
chr11:67769497(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UNC93B1
chr11:67758676-67758677(-) m6A 3'UTR//exon       -
chr11:67758773-67758774(-) m6A 3'UTR//exon       -
chr11:67758813-67758814(-) m6A 3'UTR//exon       -
chr11:67758944-67758945(-) m6A 3'UTR//intron       24284625//25456834//24981863//28052920//27371828//27773536//22608085
chr11:67758996-67758997(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr11:67759052-67759053(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr11:67759079-67759080(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr11:67759176-67759177(-) m6A CDS//intron       27773536
chr11:67761248-67761249(-) Y CDS//exon//intron       26075521
chr11:67765857-67765858(-) m6A 3'UTR//CDS//exon       27773535
chr11:67765878-67765879(-) m6A 3'UTR//CDS//exon       27773535
chr11:67771318-67771319(-) m6A exon//intron       27371828//27773536
chr11:67771406-67771407(-) m6A exon//intron       27773536
chr11:67771451-67771452(-) m6A CDS//exon//intron       24981863//27371828//27773536
chr11:67771552-67771553(-) m6A 5'UTR//exon//intron       24981863
chr11:67772329-67772330(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-330-5p
Exosome HCC tissues     30542726
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
UNC93B1
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-330-5p
D-Glucose 5793 Drug interaction    RC00007082
Mistletoe lectin-I - Drug interaction    RC00007083
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-330-5p
Etoposide 36462       23028896

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-330-5p
Interactor2: UNC93B1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Upregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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