Basic Information:

  VIRBase ID:  

HHID00024768

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-379-3p:  MIMAT0004690          GTPBP1:  NM_004286     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-379-3p	GTPBP1
miRBase Accession/Entrez ID	MIMAT0004690	9567
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GP-1//GP1//HSPC018

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-379-3p	rs1267644677 chr14:101022128    ACT/A rs1376071062 chr14:101022117    A/G rs1416546339 chr14:101022126    T/C rs996338461 chr14:101022128    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GTPBP1	chr22:39108015(+) A-I      intronic chr22:39107583(+) A-I      intronic chr22:39108069(+) A-I      intronic chr22:39107651(+) A-I      intronic chr22:39107950(+) A-I      intronic chr22:39107985(+) A-I      intronic chr22:39107686(+) A-I      intronic chr22:39107589(+) A-I      intronic chr22:39107728(+) A-I      intronic chr22:39108154(+) A-I      intronic chr22:39107909(+) A-I      intronic chr22:39117270(+) A-I      intronic chr22:39110324(+) A-I      intronic chr22:39107986(+) A-I      intronic chr22:39107989(+) A-I      intronic chr22:39105177(+) A-I      intronic chr22:39107763(+) A-I      intronic chr22:39107741(+) A-I      intronic chr22:39107665(+) A-I      intronic chr22:39107727(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GTPBP1	chr22:39107665(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GTPBP1	chr22:39101991-39101992(+) m6A CDS//intron       24209618//24981863 chr22:39102093-39102094(+) m6A CDS//intron       24209618//24981863//22575960 chr22:39102138-39102139(+) m6A CDS//exon//intron       22575960 chr22:39102835-39102836(+) m6A 5'UTR//intron       - chr22:39104933-39104934(+) m6A CDS//exon//intron       24284625//24209618//24981863 chr22:39111916-39111917(+) m6A CDS//exon       24284625//24209618//24981863 chr22:39111981-39111982(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr22:39112070-39112071(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr22:39112108-39112109(+) m6A exon//intron       24284625//24209618//24981863//22575960 chr22:39112727-39112728(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr22:39112755-39112756(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr22:39112770-39112771(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr22:39112847-39112848(+) m6A 3'UTR//CDS       - chr22:39124010-39124011(+) m6A CDS       - chr22:39124021-39124022(+) Y CDS       26075521 chr22:39124032-39124033(+) m6A CDS       - chr22:39124038-39124039(+) m6A CDS       - chr22:39124056-39124057(+) m6A CDS       - chr22:39124088-39124089(+) m6A CDS       - chr22:39124110-39124111(+) m6A CDS       24981863 chr22:39124274-39124275(+) m6A exon//intron       24981863 chr22:39125475-39125476(+) m6A CDS//exon       24981863 chr22:39125497-39125498(+) m6A CDS//exon       24981863 chr22:39126709-39126710(+) m6A 3'UTR//exon//intron       24284625 chr22:39126894-39126895(+) m6A 3'UTR//exon//intron       24981863 chr22:39126905-39126906(+) m6A 3'UTR//exon//intron       24981863 chr22:39127831-39127832(+) Y 3'UTR//exon//intron       26075521 chr22:39127838-39127839(+) m6A 3'UTR//exon//intron       - chr22:39127882-39127883(+) m6A 3'UTR//exon//intron       25456834 chr22:39127899-39127900(+) m6A 3'UTR//exon//intron       25456834 chr22:39127924-39127925(+) m6A 3'UTR//exon//intron       25456834 chr22:39127942-39127943(+) m6A 3'UTR//exon//intron       25456834 chr22:39127976-39127977(+) m6A 3'UTR//exon//intron       25456834 chr22:39127986-39127987(+) m6A 3'UTR//exon//intron       25456834 chr22:39128061-39128062(+) m6A 3'UTR//exon//intron       25456834 chr22:39128836-39128837(+) m6A 3'UTR//intron       24209618 chr22:39128887-39128888(+) m6A 3'UTR//intron       24209618 chr22:39130223-39130224(+) m6A 3'UTR//intron       - chr22:39130232-39130233(+) m6A 3'UTR//intron       - chr22:39131230-39131231(+) m6A CDS//intron       - chr22:39132123-39132124(+) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//26404942 chr22:39134224-39134225(+) m6A 3'UTR       27773535 chr22:39134266-39134267(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-379-3p	Exosome Saliva     19627513 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	GTPBP1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-379-3p
Interactor2: GTPBP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).