Basic Information:

  VIRBase ID:  

HHID00024582

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-758-3p:  MIMAT0003879          TLR3:  NM_003265     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-758-3p	TLR3
miRBase Accession/Entrez ID	MIMAT0003879	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-758-3p	rs1165305945 chr14:101026084    C/T rs1432780238 chr14:101026090    A/G rs992122694 chr14:101026080    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-758-3p	Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-758-3p	8-Aminoadenosine 96851 Drug resistant 1,9-Pyrazoloanthrone 8515 Drug resistant Berberine iodide 72350 Drug sensitive 1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant 3-[[4-[[2-(Methoxycarbonylamino)-3H-benzimidazol-5-yl]oxy]phenyl]carbamoylamino]benzoic acid;hydrochloride 57399799 Drug sensitive 2-Azaadenine 5480214 Drug resistant 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive 2-Methylolivacinium acetate 5458752 Drug sensitive Xestin A 5352066 Drug resistant 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive 6-Bromosangivamycin 470030 Drug resistant Musennin 441933 Drug sensitive Isobrucein A 441802 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive Elliptinium acetate 42722 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive 1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant Haloprogin 3561 Drug resistant Maxima isoflavone D 343081 Drug sensitive Ellipticine 3213 Drug sensitive 8-Trichloromethyldihydroberberine 320713 Drug sensitive 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive 4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant Sarcoviolin 24202820 Drug sensitive Kinetin riboside 20345 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant (1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant Formycin b 135449281 Drug resistant 3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug resistant Unii-9JU14BJ5QG 109374088 Drug sensitive 1,6:2,3-dianhydro-4-o-benzyl-.beta.-d-mannopyranose - Drug resistant inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive 2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 2-methylellpticinium - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive protein: pahiv4 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-758-3p	10-Hydroxycamptothecin 97226 Drug interaction    RC00006643 Cholesterol 5997 Drug interaction    RC00006640 Diethylstilbestrol 448537 Drug interaction    RC00006644 Etoposide 36462 Drug interaction    RC00006642 5-Fluorouracil 3385 Drug interaction    RC00006639 Doxorubicin 31703 Drug interaction    RC00006641 Verapamil 2520 Drug interaction    RC00006638

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-758-3p
Interactor2: TLR3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).