Basic Information:

  VIRBase ID:  

HHID00024228

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-381-3p:  MIMAT0000736          TLR3:  NM_003265     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-381-3p	TLR3
miRBase Accession/Entrez ID	MIMAT0000736	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-381-3p	rs1017172007 chr14:101045977    G/C rs763142743 chr14:101045988    G/A rs775776541 chr14:101045968    T/A rs776581200 chr14:101045987    TGTGA/T rs1242677465 chr14:101045969    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-381-3p	Exosome Serum     18589210 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Blood|Endothelial cells     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-381-3p	8-Aminoadenosine 96851 Drug resistant Ambrosin 92119 Drug resistant (3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant 1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug resistant 4beta-Hydroxywithanolide E 73621 Drug resistant Berberine iodide 72350 Drug sensitive 1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant 1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant Silver mesylate 6712944 Drug resistant Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant Crotonoside 65085 Drug resistant Jatrophon 6325446 Drug resistant 2-Azaadenine 5480214 Drug resistant 5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive [(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant Biantrazole 54607781 Drug sensitive Selendale 54601159 Drug sensitive Stereoisomer of 672120 (MW=262) 5459262 Drug resistant 2-Methylolivacinium acetate 5458752 Drug sensitive Ovatifolin acetate 5358419 Drug resistant Xestin A 5352066 Drug resistant 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant Vorinostat 5311 Drug resistant Eupachlorin 5281446 Drug resistant 6-Bromosangivamycin 470030 Drug resistant Patulin 4696 Drug resistant Justicidin B 442882 Drug resistant Suavedol 442245 Drug resistant Musennin 441933 Drug sensitive Isobrucein A 441802 Drug sensitive Antibiotic X-14766A 434840 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive Elliptinium acetate 42722 Drug sensitive Carboplatin 426756 Drug sensitive Mitoxantrone 4212 Drug sensitive 5,8-Quinolinedione, 2-methyl- 388305 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant 1-Azido-2-formyl-benzo[ij]quinolizin-3-one 381901 Drug resistant Carquniostatin B 380452 Drug resistant 2-Chloro-3-(1-(4-methyl)piperazino)naphthazarin 378627 Drug resistant 2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant Antineoplastic-D648114 372647 Drug sensitive 2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive 2-Hydroxy discorhabdin D 362391 Drug resistant 1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant Thiosangivamycin 3580213 Drug resistant Haloprogin 3561 Drug resistant Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive p-Bromophenacyl benzoate 345792 Drug resistant Maxima isoflavone D 343081 Drug sensitive Ellipticine 3213 Drug sensitive 9-Methoxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium iodide 3086380 Drug sensitive 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive 4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant [(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug resistant 1-(3-Diethylarsino-3-thio-2-methyl-1-oxopropyl)-L-proline 24203225 Drug resistant Sarcoviolin 24202820 Drug sensitive Tartrolon b 23685389 Drug sensitive Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive Kinetin riboside 20345 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant Sangivamycin monohydrate 16219974 Drug resistant Paucin 161538 Drug resistant [(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant (1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant Methyl ester prodigiosene 136040158 Drug resistant Oxanthrazole 135502299 Drug sensitive Formycin b 135449281 Drug resistant Salicylidene salicylhydrazide 135445765 Drug resistant Allopurinol 135401907 Drug resistant 43-Dioxypectenotoxin 131751434 Drug sensitive (2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug resistant 1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug sensitive Litmomycin 12310334 Drug resistant Pararosaniline hydrochloride 11292 Drug sensitive 2,9-Dimethylellipticinium acetate 10472068 Drug sensitive 15,16-Dihydrocuracin A 101683509 Drug resistant 2-N-Methyl-6-oxaellipticinium acetate 10018975 Drug sensitive 1h-pyrazole-1-ethanol, 4,4'-azoxybis(3,5-dimethyl- - Drug resistant 2-(p-nitrophenoxy)carbonyl-1,2-dihydroellipticine - Drug resistant 2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug resistant 2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug resistant 4-piperidinone, 1-methyl-2,6-bis[(2-nitrophenyl)methylene]- - Drug resistant ethyl, methoxy, prodigisine - Drug resistant furan-2(3h)-one, 5-(4-methylphenyl)-3,3-diphenyl- - Drug resistant inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant 2'-o-(all trans)-retinoyl-erythromicine a - Drug resistant bafilomycin antibiotic - Drug resistant bis(2-nitrophenyl)sulfilimine - Drug resistant geldanamycin analog - Drug resistant granatomycin a - Drug resistant o-linoleoyl-2-butoxy-1-desoamine - Drug resistant o-linoleoyl-6-d-glucose - Drug resistant xenorhabdin 1 - Drug resistant 1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive 1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive 5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive naphtho[1,2-b]quinolizinium, 9-methyl-, bromide - Drug sensitive phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive 2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 2-(n-d-glysoyl)aminobenzothiazole - Drug sensitive 2-methylellpticinium - Drug sensitive active compound from cephalodiscus gilchristi - Drug sensitive Annamycin Liposomal - Drug sensitive Camptothecin Derivative - Drug sensitive chrysarobin - Drug sensitive CI-921: amsacrine derivative - Drug sensitive protein: pahiv4 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-381-3p	D-Glucose 5793 Drug interaction    RC00004255 Temozolomide 5394 Drug interaction    RC00004254 Vorinostat 5311 Drug interaction    RC00004253 5-Fluorouracil 3385 Drug interaction    RC00004252 Doxorubicin 31703 Drug interaction    RC00004256 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004257 Bicalutamide 2375 Drug interaction    RC00004251 Docetaxel 148124 Drug interaction    RC00004258 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004259 Chemotherapy - Drug interaction    RC00008859

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-381-3p	Doxorubicin 31703       29242506 Rituximab -       29242506

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-381-3p
Interactor2: TLR3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//miRTarBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32232013	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVEC cells	Interactor2 expression	Upregulation
Description	Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).