Detail Information

Basic Information:


  VIRBase ID:  

HHID00023792

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-149-5p:           STAT1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-149-5p STAT1
miRBase
Accession/Entrez ID		 MIMAT0000450 6772
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CANDF7//IMD31A//IMD31B//IMD31C//ISGF-3//STAT91

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-149-5p
rs773885113 chr2:240456037    C/T
rs901919526 chr2:240456023    C/T
rs998903950 chr2:240456024    G/A
rs998903950 chr2:240456024    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STAT1
chr2:191857962(-) A-I      intronic
chr2:191857972(-) A-I      intronic
chr2:191857971(-) A-I      intronic
chr2:191857965(-) A-I      intronic
chr2:191858040(-) A-I      intronic
chr2:191858035(-) A-I      intronic
chr2:191858030(-) A-I      intronic
chr2:191858014(-) A-I      intronic
chr2:191858007(-) A-I      intronic
chr2:191857990(-) A-I      intronic
chr2:191857979(-) A-I      intronic
chr2:191858012(-) A-I      intronic
chr2:191876684(-) A-I      intronic
chr2:191876676(-) A-I      intronic
chr2:191859560(-) A-I      intronic
chr2:191876709(-) A-I      intronic
chr2:191876773(-) A-I      intronic
chr2:191876704(-) A-I      intronic
chr2:191876242(-) A-I      intronic
chr2:191857558(-) A-I      intronic
chr2:191836430(-) A-I      intronic
chr2:191876922(-) A-I      intronic
chr2:191876966(-) A-I      intronic
chr2:191877060(-) A-I      intronic
chr2:191876947(-) A-I      intronic
chr2:191877079(-) A-I      intronic
chr2:191877055(-) A-I      intronic
chr2:191877134(-) A-I      intronic
chr2:191877059(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STAT1
chr2:191858027(-) A-I intron -    22327324
chr2:191858032(-) A-I intron -    22327324
chr2:191858041(-) A-I intron -    22327324
chr2:191858235(-) A-I intron -    22327324
chr2:191876242(-) A-I intron -    22327324
chr2:191876947(-) A-I intron -    22327324
chr2:191857252(-) A-I intron -    21960545
chr2:191857334(-) A-I intron -    21960545
chr2:191836426(-) A-G intron -    22484847
chr2:191836428(-) G-A intron -    22484847
chr2:191836430(-) A-G intron -    22484847
chr2:191836434(-) G-A intron -    22484847
chr2:191836438(-) G-A intron -    22484847
chr2:191836442(-) A-G intron -    22484847
chr2:191853286(-) G-T intron -    22484847
chr2:191863398(-) G-T intron -    22484847
chr2:191863399(-) T-G intron -    22484847
chr2:191863407(-) G-T intron -    22484847
chr2:191863408(-) T-G intron -    22484847
chr2:191876242(-) A-G intron -    22484847
chr2:191876253(-) A-G intron -    22484847
chr2:191876277(-) A-G intron -    22484847
chr2:191876917(-) A-G intron -    22484847
chr2:191876922(-) A-G intron -    22484847
chr2:191876947(-) A-G intron -    22484847
chr2:191876966(-) A-G intron -    22484847
chr2:191877055(-) A-G intron -    22484847
chr2:191877059(-) A-G intron -    22484847
chr2:191877060(-) A-G intron -    22484847
chr2:191877079(-) A-G intron -    22484847
chr2:191877134(-) A-G intron -    22484847
chr2:191876283(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STAT1
chr2:191833967-191833968(-) Y 3'UTR//intron       26075521
chr2:191834403-191834404(-) m6A 3'UTR//intron       26404942
chr2:191835032-191835033(-) m6A 3'UTR//intron       22575960
chr2:191835175-191835176(-) m6A 3'UTR//intron       22575960
chr2:191841603-191841604(-) m6A 3'UTR//CDS       26404942
chr2:191850374-191850375(-) m6A 3'UTR//CDS       22575960
chr2:191851628-191851629(-) m6A 3'UTR//CDS       22575960
chr2:191856027-191856028(-) m6A 3'UTR//CDS       26404942
chr2:191859822-191859823(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191859840-191859841(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191859860-191859861(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191859878-191859879(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191862584-191862585(-) m6A 3'UTR//CDS       24981863//26404942//27773535
chr2:191862640-191862641(-) m6A 3'UTR//CDS       24981863//28052920//26404942//27773535
chr2:191862661-191862662(-) m6A 3'UTR//CDS       24981863//28052920//26404942//27773535//22575960
chr2:191862691-191862692(-) m6A 3'UTR//CDS       24981863//28052920//26404942//27773535//22575960
chr2:191862990-191862991(-) m6A CDS//intron       24981863//28052920//27773535//22575960
chr2:191862996-191862997(-) m6A CDS//intron       24981863//28052920//27773535//22575960
chr2:191863025-191863026(-) m6A CDS//intron       24981863//28052920//27773535//22575960
chr2:191864356-191864357(-) m6A CDS       24981863//28052920//27773535//22575960
chr2:191864366-191864367(-) m6A CDS       24981863//28052920//27773535//22575960
chr2:191865809-191865810(-) m6A CDS       24981863//28052920//26404942//27773535//22575960
chr2:191865851-191865852(-) m6A CDS       24981863//26404942//27773535//22575960
chr2:191878510-191878511(-) m6A 5'UTR//intron       27371828
chr2:191878788-191878789(-) Y 5'UTR//intron       25219674
chr2:191878824-191878825(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536
chr2:191878831-191878832(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-149-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     24683445
Exosome Endothelial cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
STAT1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-149-5p
Gemcitabine 60750 Drug interaction    RC00003170
Temozolomide 5394 Drug interaction    RC00003165
Goserelinacetate 47725 Drug interaction    RC00003169
Bortezomib 387447 Drug interaction    RC00003173
Paclitaxel 36314 Drug interaction    RC00003168
5-Fluorouracil 3385 Drug interaction    RC00003164
Doxorubicin 31703 Drug interaction    RC00003167
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003163
Tamoxifen 2733526 Drug interaction    RC00003174
Bicalutamide 2375 Drug interaction    RC00003162
Arsenic trioxide 14888 Drug interaction    RC00003166
Docetaxel 148124 Drug interaction    RC00003172
Methotrexate 126941 Drug interaction    RC00003171
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003175
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-149-5p
Cisplatin 5702198       29393390

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-149-5p
Interactor2: STAT1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Upregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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