Detail Information

Basic Information:


  VIRBase ID:  

HHID00023656

  Virus:  

Hantaan orthohantavirus (Hantaan virus 76-118)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-221-3p:           ZMAT3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-221-3p ZMAT3
miRBase
Accession/Entrez ID		 MIMAT0000278 64393
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PAG608//WIG-1//WIG1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-221-3p
rs1555935979 chrX:45746180    G/A
rs1555935982 chrX:45746185    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZMAT3
chr3:178748281(-) A-I      intronic
chr3:178748303(-) A-I      intronic
chr3:178748370(-) A-I      intronic
chr3:178749576(-) A-I      intronic
chr3:178749657(-) A-I      intronic
chr3:178782333(-) A-I      intronic
chr3:178782438(-) A-I      intronic
chr3:178782514(-) A-I      intronic
chr3:178746785(-) A-I      intronic
chr3:178746826(-) A-I      intronic
chr3:178746908(-) A-I      intronic
chr3:178782498(-) A-I      intronic
chr3:178782315(-) A-I      intronic
chr3:178749529(-) A-I      intronic
chr3:178749503(-) A-I      intronic
chr3:178782320(-) A-I      intronic
chr3:178748319(-) A-I      intronic
chr3:178749515(-) A-I      intronic
chr3:178749573(-) A-I      intronic
chr3:178748414(-) A-I      intronic
chr3:178749583(-) A-I      intronic
chr3:178744351(-) A-I      intronic
chr3:178762265(-) A-I      intronic
chr3:178783601(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZMAT3
chr3:178740951(-) G-A exon 3'UTR    22484847
chr3:178744455(-) G-C intron -    22484847
chr3:178748414(-) A-G intron -    22484847
chr3:178749503(-) A-G intron -    22484847
chr3:178749515(-) A-G intron -    22484847
chr3:178749529(-) A-G intron -    22484847
chr3:178749573(-) A-G intron -    22484847
chr3:178749583(-) A-G intron -    22484847
chr3:178765486(-) G-T intron -    22484847
chr3:178778367(-) T-C intron -    22484847
chr3:178782498(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZMAT3
chr3:178738549-178738550(-) m6A 3'UTR       -
chr3:178738614-178738615(-) m6A 3'UTR       -
chr3:178742341-178742342(-) m6A 3'UTR       -
chr3:178748766-178748767(-) m6A CDS       24981863//27773535//22608085
chr3:178785301-178785302(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:178785321-178785322(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr3:178785361-178785362(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr3:178785388-178785389(-) m1A CDS       26863196
chr3:178785452-178785453(-) m6A CDS       24284625//24981863//22575960
chr3:178785588-178785589(-) m6A 5'UTR       -
chr3:178789557-178789558(-) m6A 5'UTR       25456834//24981863//27371828
chr3:178789819-178789820(-) m6A 5'UTR       27371828
chr3:178789857-178789858(-) m6A 5'UTR       27371828
chr3:178789948-178789949(-) m6A 5'UTR       24981863//27371828
chr3:178789957-178789958(-) m6A 5'UTR       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-221-3p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Colorectal cancer cell lines (HCT-15|SW480|WiDr)     22895844
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|B lymphoblastoid cells|Breast tissue|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion HEK-293 cells|HeLa cells|Myotube     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
ZMAT3
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-221-3p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive
Mevastatin 64715 Drug sensitive
Simvastatin 54454 Drug sensitive
Lovastatin 53232 Drug sensitive
(3R,5S)-Fluvastatin(1-) 37888681 Drug sensitive
Gardenin A 261859 Drug sensitive
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug sensitive
(1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug resistant
4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug resistant
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug resistant
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug resistant
organosulfur compound - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide - Drug sensitive
atorvastatin calcium (usan) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-221-3p
Hyaluronidase 91820602 Drug interaction    RC00002198
Oxaliplatine 6857599 Drug interaction    RC00002196
Fludarabine 657237 Drug interaction    RC00002189
Aniline 6115 Drug interaction    RC00002170
Capecitabine 60953 Drug interaction    RC00002179
Atorvastatin 60823 Drug interaction    RC00002178
Gemcitabine 60750 Drug interaction    RC00002177
Vincristine 5978 Drug interaction    RC00002169
Dexamethasone 5743 Drug interaction    RC00002168
CID 56842234 56842234 Drug interaction    RC00002197
Simvastatin 54454 Drug interaction    RC00002176
Temozolomide 5394 Drug interaction    RC00002167
Sunitinib 5329102 Drug interaction    RC00002195
Eloxatine 5310940 Drug interaction    RC00002194
Morphine 5288826 Drug interaction    RC00002193
Cholecalciferol 5280795 Drug interaction    RC00002192
Melphalan 460612 Drug interaction    RC00002188
Docosahexaenoic acid 445580 Drug interaction    RC00002187
Trichostatin A 444732 Drug interaction    RC00002186
Metformin 4091 Drug interaction    RC00002166
Paclitaxel 36314 Drug interaction    RC00002175
5-Fluorouracil 3385 Drug interaction    RC00002165
Emodin 3220 Drug interaction    RC00002164
Doxorubicin 31703 Drug interaction    RC00002174
Lithium 3028194 Drug interaction    RC00002191
Lithium ion 28486 Drug interaction    RC00002173
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002163
Tamoxifen 2733526 Drug interaction    RC00002190
Carmustine 2578 Drug interaction    RC00002162
Verapamil 2520 Drug interaction    RC00002161
Nandrolone phenpropionate 229455 Drug interaction    RC00002185
Lapatinib 208908 Drug interaction    RC00002184
Arsenic trioxide 14888 Drug interaction    RC00002172
Docetaxel 148124 Drug interaction    RC00002183
Leucovorin 135403648 Drug interaction    RC00002199
Gefitinib 123631 Drug interaction    RC00002182
Ginsenoside Rh2 119307 Drug interaction    RC00002181
Androstanolone 10635 Drug interaction    RC00002171
Fulvestrant 104741 Drug interaction    RC00002180
AED therapy - Drug interaction    RC00002200
TRAIL therapy - Drug interaction    RC00002201
Trastuzumab - Drug interaction    RC00002202
Chemotherapy - Drug interaction    RC00008837
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-221-3p
5-Fluorouracil 3385       27726102

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-221-3p
Interactor2: ZMAT3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//miRTarBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32232013 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HUVEC cells Interactor2 expression Downregulation
Description Then we predicted 320 target genes of these 16 DE miRNAs and constructed a miRNA-mRNA interaction network (Figure 5B, Table S5).

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