Detail Information

Basic Information:


  VIRBase ID:  

HHID00023521

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-210-5p:           CFB:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-210-5p CFB
miRBase
Accession/Entrez ID		 MIMAT0026475 629
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AHUS4//ARMD14//BF//BFD//CFAB//CFBD//FB//FBI12//GBG//H2-Bf//PBF2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-210-5p
rs1307849834 chr11:568150    C/T
rs1328893125 chr11:568155    T/A
rs1339953548 chr11:568159    G/A
rs1392659721 chr11:568157    C/T
rs1393385015 chr11:568155    TGC/T
rs1394548019 chr11:568152    G/C
rs1484589425 chr11:568153    T/C
rs758885854 chr11:568158    G/A
rs764507105 chr11:568162    G/A
rs764507105 chr11:568162    G/T
rs887377650 chr11:568163    G/A
rs1317060428 chr11:568166    G/A
rs1373131153 chr11:568167    G/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CFB
chr6:31913915-31913916(+) m6A 5'UTR//exon       24981863
chr6:31913931-31913932(+) m6A 5'UTR//exon       24981863
chr6:31913950-31913951(+) m6A 5'UTR//exon       24981863
chr6:31916034-31916035(+) m6A exon//intron       24284625
chr6:31917866-31917867(+) m6A CDS//exon//intron       27773535
chr6:31918076-31918077(+) m6A CDS//exon//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-210-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Plasma     19289371
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
Nucleus Neural progenitor cells     21363885
CFB
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-210-5p
Interactor2: CFB

Evidence Support:


Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence DIANA//miRanda//PicTar//Targetscan
Support Database ViRBase

References:


PMID 31992777 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line TEC cells Interactor2 expression None
Description The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.

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