Basic Information:

  VIRBase ID:  

HHID00023516

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4458:  MIMAT0018980          JAM2:  NM_001270407     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4458	JAM2
miRBase Accession/Entrez ID	MIMAT0018980	58494
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C21orf43//CD322//IBGC8//JAM-B//JAMB//PRO245//VE-JAM//VEJAM

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4458	rs1412148153 chr5:8460934    G/C rs1474483700 chr5:8460935    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	JAM2	chr21:27080832(+) A-I      intronic chr21:27080837(+) A-I      intronic chr21:27088435(+) A-I      3'UTR chr21:27080840(+) A-I      intronic chr21:27080805(+) A-I      intronic chr21:27088436(+) A-I      3'UTR chr21:27088439(+) A-I      3'UTR chr21:27088459(+) A-I      3'UTR chr21:27080269(+) A-I      intronic chr21:27088476(+) A-I      3'UTR chr21:27088489(+) A-I      3'UTR chr21:27088373(+) A-I      3'UTR chr21:27050388(+) A-I      intronic chr21:27088497(+) A-I      3'UTR chr21:27088352(+) A-I      3'UTR chr21:27088360(+) A-I      3'UTR chr21:27017237(+) A-I      intronic chr21:27034589(+) A-I      intronic chr21:27038241(+) A-I      intronic chr21:27041465(+) A-I      intronic chr21:27078674(+) A-I      intronic chr21:27041489(+) A-I      intronic chr21:27041529(+) A-I      intronic chr21:27048385(+) A-I      intronic chr21:27048414(+) A-I      intronic chr21:27048565(+) A-I      intronic chr21:27050361(+) A-I      intronic chr21:27078677(+) A-I      intronic chr21:27079651(+) A-I      intronic chr21:27080773(+) A-I      intronic chr21:27050382(+) A-I      intronic chr21:27051167(+) A-I      intronic chr21:27051237(+) A-I      intronic chr21:27057726(+) A-I      intronic chr21:27057735(+) A-I      intronic chr21:27072790(+) A-I      intronic chr21:27086616(+) A-I      NonSyn:Stp->Trp chr21:27069958(+) A-I      intronic chr21:27051212(+) A-I      intronic chr21:27069956(+) A-I      intronic chr21:27080867(+) A-I      intronic chr21:27080782(+) A-I      intronic chr21:27080256(+) A-I      intronic chr21:27072934(+) A-I      intronic chr21:27080283(+) A-I      intronic chr21:27079697(+) A-I      intronic chr21:27038174(+) A-I      intronic chr21:27078574(+) A-I      intronic chr21:27078594(+) A-I      intronic chr21:27079311(+) A-I      intronic chr21:27080398(+) A-I      intronic chr21:27080274(+) A-I      intronic chr21:27072873(+) A-I      intronic chr21:27078514(+) A-I      intronic chr21:27033678(+) A-I      intronic chr21:27072709(+) A-I      intronic chr21:27032330(+) A-I      intronic chr21:27086665(+) A-I      3'UTR chr21:27086660(+) A-I      3'UTR chr21:27086725(+) A-I      3'UTR chr21:27086695(+) A-I      3'UTR chr21:27086655(+) A-I      3'UTR chr21:27088363(+) A-I      3'UTR chr21:27086789(+) A-I      3'UTR chr21:27069982(+) A-I      intronic chr21:27057120(+) A-I      intronic chr21:27080868(+) A-I      intronic chr21:27080652(+) A-I      intronic chr21:27080786(+) A-I      intronic chr21:27079647(+) A-I      intronic chr21:27079781(+) A-I      intronic chr21:27079714(+) A-I      intronic chr21:27041498(+) A-I      intronic chr21:27080783(+) A-I      intronic chr21:27041499(+) A-I      intronic chr21:27080682(+) A-I      intronic chr21:27057074(+) A-I      intronic chr21:27033555(+) A-I      intronic chr21:27041542(+) A-I      intronic chr21:27057778(+) A-I      intronic chr21:27079634(+) A-I      intronic chr21:27079312(+) A-I      intronic chr21:27079703(+) A-I      intronic chr21:27079700(+) A-I      intronic chr21:27020412(+) A-I      intronic chr21:27078556(+) A-I      intronic chr21:27078587(+) A-I      intronic chr21:27080781(+) A-I      intronic chr21:27072802(+) A-I      intronic chr21:27032371(+) A-I      intronic chr21:27064220(+) A-I      intronic chr21:27069245(+) A-I      intronic chr21:27079673(+) A-I      intronic chr21:27079709(+) A-I      intronic chr21:27033500(+) A-I      intronic chr21:27056997(+) A-I      intronic chr21:27069449(+) A-I      intronic chr21:27080422(+) A-I      intronic chr21:27080377(+) A-I      intronic chr21:27080808(+) A-I      intronic chr21:27041508(+) A-I      intronic chr21:27051181(+) A-I      intronic chr21:27039078(+) A-I      intronic chr21:27048544(+) A-I      intronic chr21:27080434(+) A-I      intronic chr21:27069307(+) A-I      intronic chr21:27079083(+) A-I      intronic chr21:27041429(+) A-I      intronic chr21:27033652(+) A-I      intronic chr21:27033654(+) A-I      intronic chr21:27086607(+) A-I      NonSyn:Gln->Arg

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	JAM2	chr21:27011616-27011617(+) m6A 5'UTR       - chr21:27011658-27011659(+) m6A 5'UTR       - chr21:27011842-27011843(+) m6A 5'UTR       - chr21:27011902-27011903(+) m6A 5'UTR       25456834 chr21:27011907-27011908(+) m6A 5'UTR       25456834 chr21:27011933-27011934(+) m6A 5'UTR       25456834 chr21:27011980-27011981(+) m6A 5'UTR       25456834 chr21:27012091-27012092(+) m6A 5'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4458	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	JAM2	Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4458
Interactor2: JAM2

Evidence Support:

Weak-Evidence	RNA-Seq//Small RNA sequencing
Prediction-Evidence	DIANA//miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	31992777	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	TEC cells	Interactor2 expression	None
Description	The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.