Basic Information:

  VIRBase ID:  

HHID00023513

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4458:  MIMAT0018980          COLQ:  NM_080539     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4458	COLQ
miRBase Accession/Entrez ID	MIMAT0018980	8292
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CMS5//EAD

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4458	rs1412148153 chr5:8460934    G/C rs1474483700 chr5:8460935    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	COLQ	chr3:15507203(-) A-I      intronic chr3:15506543(-) A-I      intronic chr3:15505018(-) A-I      intronic chr3:15500488(-) A-I      intronic chr3:15505023(-) A-I      intronic chr3:15505095(-) A-I      intronic chr3:15505148(-) A-I      intronic chr3:15507197(-) A-I      intronic chr3:15557244(-) A-I      intronic chr3:15507339(-) A-I      intronic chr3:15550486(-) A-I      intronic chr3:15533532(-) A-I      intronic chr3:15498598(-) A-I      intronic chr3:15533521(-) A-I      intronic chr3:15498486(-) A-I      intronic chr3:15498441(-) A-I      intronic chr3:15498405(-) A-I      intronic chr3:15505008(-) A-I      intronic chr3:15501077(-) A-I      intronic chr3:15501232(-) A-I      intronic chr3:15506612(-) A-I      intronic chr3:15507344(-) A-I      intronic chr3:15538615(-) A-I      intronic chr3:15507237(-) A-I      intronic chr3:15507354(-) A-I      intronic chr3:15507046(-) A-I      intronic chr3:15514670(-) A-I      intronic chr3:15551990(-) A-I      intronic chr3:15501265(-) A-I      intronic chr3:15548531(-) A-I      intronic chr3:15548516(-) A-I      intronic chr3:15506532(-) A-I      intronic chr3:15506476(-) A-I      intronic chr3:15507393(-) A-I      intronic chr3:15498595(-) A-I      intronic chr3:15549046(-) A-I      intronic chr3:15501165(-) A-I      intronic chr3:15506518(-) A-I      intronic chr3:15506557(-) A-I      intronic chr3:15507273(-) A-I      intronic chr3:15498453(-) A-I      intronic chr3:15538733(-) A-I      intronic chr3:15507264(-) A-I      intronic chr3:15506598(-) A-I      intronic chr3:15549009(-) A-I      intronic chr3:15535513(-) A-I      intronic chr3:15507045(-) A-I      intronic chr3:15506569(-) A-I      intronic chr3:15552158(-) A-I      intronic chr3:15506438(-) A-I      intronic chr3:15505126(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	COLQ	chr3:15505132(-) A-G intron -    22484847 chr3:15506426(-) A-G intron -    22484847 chr3:15506438(-) A-G intron -    22484847 chr3:15507354(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	COLQ	chr3:15492518-15492519(-) m6A 3'UTR       25456834//27773535//27371828//22608085 chr3:15492543-15492544(-) m6A 3'UTR       25456834//27773535//27371828//22608085 chr3:15492602-15492603(-) m6A 3'UTR       24284625//25456834//27773535//27371828//22608085 chr3:15492614-15492615(-) m6A 3'UTR       24284625//25456834//27773535//27371828//22608085 chr3:15492666-15492667(-) m6A 3'UTR       25456834//27773535//27371828//22608085 chr3:15492803-15492804(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr3:15492813-15492814(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085 chr3:15492833-15492834(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr3:15492887-15492888(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr3:15492917-15492918(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr3:15492940-15492941(-) m6A 3'UTR       24284625//27773535//22608085 chr3:15492976-15492977(-) m6A 3'UTR       24284625//27773535//22608085 chr3:15493013-15493014(-) m6A 3'UTR       24284625//27773535//22608085 chr3:15493032-15493033(-) m6A 3'UTR       24284625//27773535//22608085 chr3:15493038-15493039(-) m6A 3'UTR       24284625//27773535//22608085 chr3:15493085-15493086(-) m6A 3'UTR       27773535 chr3:15493114-15493115(-) m6A 3'UTR       - chr3:15507941-15507942(-) m6A CDS       - chr3:15512063-15512064(-) m6A CDS       - chr3:15512075-15512076(-) m6A CDS       - chr3:15512084-15512085(-) m6A CDS       - chr3:15512099-15512100(-) m6A CDS       - chr3:15563143-15563144(-) m6A 5'UTR       - chr3:15563218-15563219(-) m6A 5'UTR       - chr3:15563234-15563235(-) m6A 5'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4458	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	COLQ	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4458
Interactor2: COLQ

Evidence Support:

Weak-Evidence	RNA-Seq//Small RNA sequencing
Prediction-Evidence	DIANA//miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	31992777	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	TEC cells	Interactor2 expression	None
Description	The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.