Basic Information:

  VIRBase ID:  

HHID00023511

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4458:  MIMAT0018980          JUNB:  NM_002229     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4458	JUNB
miRBase Accession/Entrez ID	MIMAT0018980	3726
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AP-1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4458	rs1412148153 chr5:8460934    G/C rs1474483700 chr5:8460935    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	JUNB	chr19:12902556-12902557(+) m6A 5'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:12902567-12902568(+) m6A 5'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:12902602-12902603(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:12902683-12902684(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:12902692-12902693(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:12902755-12902756(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:12902808-12902809(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:12902905-12902906(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:12903033-12903034(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:12903194-12903195(+) m6A CDS       24284625//24209618//22575960 chr19:12903310-12903311(+) m6A CDS       24284625//22575960 chr19:12903317-12903318(+) m6A CDS       24284625//22575960 chr19:12903378-12903379(+) m6A CDS       24284625//25456834//24981863//26404942//27371828//22575960 chr19:12903417-12903418(+) m6A CDS       24284625//25456834//24981863//26404942//27371828//22575960//22608085 chr19:12903477-12903478(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:12903559-12903560(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:12903616-12903617(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:12903650-12903651(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:12903727-12903728(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:12903744-12903745(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:12903754-12903755(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:12903848-12903849(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:12903958-12903959(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:12903972-12903973(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:12904020-12904021(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4458	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	JUNB	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4458
Interactor2: JUNB

Evidence Support:

Weak-Evidence	RNA-Seq//Small RNA sequencing
Prediction-Evidence	DIANA//miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	31992777	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	TEC cells	Interactor2 expression	None
Description	The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.