Detail Information

Basic Information:


  VIRBase ID:  

HHID00023510

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4458:           HLA-DOA:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4458 HLA-DOA
miRBase
Accession/Entrez ID		 MIMAT0018980 3111
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HLA-DNA//HLA-DZA//HLADZ

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4458
rs1412148153 chr5:8460934    G/C
rs1474483700 chr5:8460935    A/G

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HLA-DOA
chr6:32973019(-) A-I exon 3'UTR    15342557   //15258596
chr6:32973145(-) A-I exon 3'UTR    15342557   //15258596
chr6:32973157(-) A-I exon 3'UTR    15342557   //15258596
chr6:32973169(-) A-I exon 3'UTR    15342557   //15258596
chr6:32973217(-) A-I exon 3'UTR    15342557
chr6:32973281(-) A-I exon 3'UTR    15342557
chr6:32973575(-) A-I exon 3'UTR    15258596
chr6:32973630(-) A-I exon 3'UTR    15258596
chr6:32973631(-) A-I exon 3'UTR    15258596

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HLA-DOA
chr6:32972106-32972107(-) m6A 3'UTR       28052920
chr6:32972249-32972250(-) m6A 3'UTR       25456834//24981863//28052920
chr6:32972661-32972662(-) m6A 3'UTR       24981863
chr6:32972710-32972711(-) m6A 3'UTR       24981863//28052920
chr6:32972727-32972728(-) m6A 3'UTR       24981863//28052920
chr6:32972759-32972760(-) m6A 3'UTR       24981863//28052920
chr6:32973149-32973150(-) m6A 3'UTR       -
chr6:32975219-32975220(-) m6A 3'UTR//CDS//exon       -
chr6:32975243-32975244(-) m6A 3'UTR//CDS//exon       -
chr6:32975293-32975294(-) m6A 3'UTR//CDS//exon       27773536
chr6:32975390-32975391(-) m6A exon//intron       27773536
chr6:32977281-32977282(-) Y 5'UTR//CDS//exon       26075521
chr6:32977340-32977341(-) m6A 5'UTR//exon       -
chr6:32977346-32977347(-) m6A 5'UTR//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4458
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
HLA-DOA
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4458
Interactor2: HLA-DOA

Evidence Support:


Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence DIANA//miRanda//PicTar//Targetscan
Support Database ViRBase

References:


PMID 31992777 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line TEC cells Interactor2 expression None
Description The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.

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