Basic Information:

  VIRBase ID:  

HHID00023509

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4458:  MIMAT0018980          BRDT:  NM_001242805     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4458	BRDT
miRBase Accession/Entrez ID	MIMAT0018980	676
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BRD6//CT9//SPGF21

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4458	rs1412148153 chr5:8460934    G/C rs1474483700 chr5:8460935    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BRDT	chr1:92420501(+) A-I      intronic chr1:92417237(+) A-I      intronic chr1:92417249(+) A-I      intronic chr1:92420488(+) A-I      intronic chr1:92428016(+) A-I      intronic chr1:92427460(+) A-I      intronic chr1:92420805(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BRDT	chr1:92444548(+) A-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BRDT	chr1:92442776-92442777(+) m6A CDS//exon       27773535 chr1:92442793-92442794(+) m6A CDS//exon       27773535 chr1:92442841-92442842(+) m6A CDS//exon       27773535 chr1:92442895-92442896(+) m6A CDS//exon       27773535 chr1:92445255-92445256(+) m6A CDS       27773535 chr1:92446463-92446464(+) m6A CDS       27773535 chr1:92446508-92446509(+) m6A CDS       27773535 chr1:92446516-92446517(+) m6A CDS       27773535 chr1:92446552-92446553(+) m6A CDS       27773535 chr1:92446571-92446572(+) m6A CDS       27773535 chr1:92446648-92446649(+) m6A CDS       27773535 chr1:92446656-92446657(+) m6A CDS       27773535 chr1:92446718-92446719(+) m6A CDS       27773535 chr1:92446727-92446728(+) m6A CDS       27773535 chr1:92446852-92446853(+) m6A CDS       27773535 chr1:92446870-92446871(+) m6A CDS       27773535 chr1:92457856-92457857(+) m6A CDS       27773535 chr1:92459658-92459659(+) m6A CDS       27773535 chr1:92459693-92459694(+) m6A CDS       27773535 chr1:92470014-92470015(+) m6A CDS       27773535 chr1:92470023-92470024(+) m6A CDS       27773535 chr1:92470105-92470106(+) m6A CDS       27773535 chr1:92470113-92470114(+) m6A CDS       27773535 chr1:92470134-92470135(+) m6A CDS       27773535 chr1:92470149-92470150(+) m6A CDS       27773535 chr1:92470725-92470726(+) m6A CDS       27773535 chr1:92470753-92470754(+) m6A CDS       27773535 chr1:92470789-92470790(+) m6A CDS       27773535 chr1:92470806-92470807(+) m6A CDS       27773535 chr1:92470831-92470832(+) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4458	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	BRDT	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4458
Interactor2: BRDT

Evidence Support:

Weak-Evidence	RNA-Seq//Small RNA sequencing
Prediction-Evidence	DIANA//miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	31992777	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	TEC cells	Interactor2 expression	None
Description	The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.