Detail Information

Basic Information:


  VIRBase ID:  

HHID00023495

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3196:           TNFSF9:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3196 TNFSF9
miRBase
Accession/Entrez ID		 MIMAT0015080 8744
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 4-1BB-L//CD137L//TNLG5A

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-3196
rs2273488 chr20:63238788    C/T
rs754780663 chr20:63238801    G/T
rs768797534 chr20:63238799    G/A
rs113297757 chr20:63238789    G/A
rs550504547 chr20:63238794    G/A
rs779946725 chr20:63238793    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TNFSF9
chr19:6535717(+) A-I      3'UTR
chr19:6535806(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TNFSF9
chr19:6535728(+) G-T intron -    22484847
chr19:6535872(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TNFSF9
chr19:6531075-6531076(+) m6A CDS       24981863
chr19:6531303-6531304(+) m6A CDS       22575960
chr19:6534697-6534698(+) m6A CDS       24284625//22575960
chr19:6534862-6534863(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr19:6534892-6534893(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr19:6535019-6535020(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr19:6535052-6535053(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr19:6535104-6535105(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr19:6535138-6535139(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr19:6535218-6535219(+) m6A 3'UTR       24284625//24981863//22575960//22608085
chr19:6535249-6535250(+) m6A 3'UTR       24284625//24981863//22608085
chr19:6535349-6535350(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr19:6535412-6535413(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr19:6535420-6535421(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr19:6535561-6535562(+) m6A 3'UTR       24284625//24209618//24981863
chr19:6535575-6535576(+) m6A 3'UTR       24981863
chr19:6535620-6535621(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3196
Exosome Pooled sera     27278097
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TNFSF9
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3196
Interactor2: TNFSF9

Evidence Support:


Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence DIANA//miRanda//PicTar//Targetscan
Support Database ViRBase

References:


PMID 31992777 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line TEC cells Interactor2 expression None
Description The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.

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