Detail Information

Basic Information:


  VIRBase ID:  

HHID00023489

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:           FOSL1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1275 FOSL1
miRBase
Accession/Entrez ID		 MIMAT0005929 8061
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FRA//fra-1//FRA1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1275
rs372458638 chr6:34000019    A/AAAACC
rs377188203 chr6:34000023    C/T
rs557928121 chr6:34000019    A/T
rs758811783 chr6:34000022    G/A
rs761034364 chr6:34000017    AGAC/A
rs370361021 chr6:34000029    C/A
rs370361021 chr6:34000029    C/T
rs374728385 chr6:34000032    C/A
rs374728385 chr6:34000032    C/G
rs747378297 chr6:34000028    C/T
rs772691699 chr6:34000033    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FOSL1
chr11:65665823(-) A-I      intronic
chr11:65665860(-) A-I      intronic
chr11:65665834(-) A-I      intronic
chr11:65665816(-) A-I      intronic
chr11:65666426(-) A-I      intronic
chr11:65666430(-) A-I      intronic
chr11:65665762(-) A-I      intronic
chr11:65665705(-) A-I      intronic
chr11:65665503(-) A-I      intronic
chr11:65662759(-) A-I      intronic
chr11:65665492(-) A-I      intronic
chr11:65664865(-) A-I      intronic
chr11:65665838(-) A-I      intronic
chr11:65666256(-) A-I      intronic
chr11:65662514(-) A-I      intronic
chr11:65665395(-) A-I      intronic
chr11:65663623(-) A-I      intronic
chr11:65666370(-) A-I      intronic
chr11:65662624(-) A-I      intronic
chr11:65662845(-) A-I      intronic
chr11:65665879(-) A-I      intronic
chr11:65664812(-) A-I      intronic
chr11:65665859(-) A-I      intronic
chr11:65665812(-) A-I      intronic
chr11:65665874(-) A-I      intronic
chr11:65666227(-) A-I      intronic
chr11:65665883(-) A-I      intronic
chr11:65666226(-) A-I      intronic
chr11:65666303(-) A-I      intronic
chr11:65665821(-) A-I      intronic
chr11:65665393(-) A-I      intronic
chr11:65666264(-) A-I      intronic
chr11:65661212(-) A-I      intronic
chr11:65666195(-) A-I      intronic
chr11:65665676(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FOSL1
chr11:65664865(-) A-G intron -    22484847
chr11:65665883(-) A-G intron -    22484847
chr11:65666195(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FOSL1
chr11:65659522-65659523(-) m6A 3'UTR       24981863
chr11:65659574-65659575(-) m6A 3'UTR       24981863
chr11:65659596-65659597(-) m6A 3'UTR       24981863
chr11:65659615-65659616(-) m6A 3'UTR       24981863
chr11:65659672-65659673(-) m6A 3'UTR       24981863
chr11:65659725-65659726(-) m6A 3'UTR       24981863
chr11:65659872-65659873(-) m6A 3'UTR       24284625//27773535
chr11:65659900-65659901(-) m6A 3'UTR       24284625//24209618//27773535
chr11:65659944-65659945(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr11:65660075-65660076(-) m6A 3'UTR       24284625//24981863//27773535
chr11:65660121-65660122(-) m6A 3'UTR       24284625//24981863//27773535
chr11:65660225-65660226(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr11:65660276-65660277(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr11:65660402-65660403(-) m6A 3'UTR//CDS       24284625//24209618//27773535
chr11:65660539-65660540(-) m6A 3'UTR//5'UTR//CDS       24284625//24209618//24981863//27773535
chr11:65660627-65660628(-) m6A 3'UTR//5'UTR//CDS       24284625//24209618//24981863//27773535
chr11:65660755-65660756(-) m6A 3'UTR//5'UTR//CDS       24284625//24209618//27773535
chr11:65660763-65660764(-) m6A 5'UTR//CDS       24284625//24209618//27773535
chr11:65661505-65661506(-) m6A 5'UTR//CDS//intron       24284625//24209618
chr11:65661518-65661519(-) m6A 5'UTR//CDS//intron       24284625//24209618
chr11:65661545-65661546(-) m6A 5'UTR//CDS//intron       24209618
chr11:65664282-65664283(-) m6A CDS//intron       24284625//24209618
chr11:65667789-65667790(-) m6A CDS//intron       24209618//25456834//24981863
chr11:65667799-65667800(-) m6A CDS//intron       24209618//25456834//24981863
chr11:65667850-65667851(-) m6A 5'UTR//intron       24209618//25456834//24981863
chr11:65667876-65667877(-) m6A 5'UTR       24209618//25456834//24981863
chr11:65667900-65667901(-) m6A 5'UTR       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1275
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
FOSL1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1275
Gemcitabine 60750 Drug interaction    RC00007825
Vincristine 5978 Drug interaction    RC00007823
Eloxatine 5310940 Drug interaction    RC00007826
Paclitaxel 36314 Drug interaction    RC00007824
5-Fluorouracil 3385 Drug interaction    RC00007822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821
Marine fungal metabolite 1386A - Drug interaction    RC00007827
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1275
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1275
Interactor2: FOSL1

Evidence Support:


Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence DIANA//miRanda//PicTar//Targetscan
Support Database ViRBase

References:


PMID 31992777 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line TEC cells Interactor2 expression None
Description The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.

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