Detail Information

Basic Information:


  VIRBase ID:  

HHID00023472

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-222-5p:           HLA-B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-222-5p HLA-B
miRBase
Accession/Entrez ID		 MIMAT0004569 3106
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AS//B-4901//HLAB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-222-5p
rs1366571639 chrX:45747085    G/A
rs1555936243 chrX:45747073    A/C
rs1555936246 chrX:45747074    G/GA
rs782197941 chrX:45747077    T/A
rs782197941 chrX:45747077    T/C
rs1166075471 chrX:45747090    C/A
rs1166075471 chrX:45747090    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HLA-B
chr6:31323091(-) A-I      intronic
chr6:31323090(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HLA-B
chr6:31323766(-) A-G intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HLA-B
chr6:31321658-31321659(-) m6A 3'UTR//exon       27773535
chr6:31321666-31321667(-) m6A 3'UTR//exon       27773535
chr6:31321926-31321927(-) m6A 3'UTR//exon       22575960
chr6:31322755-31322756(-) m6A exon//intron       -
chr6:31322899-31322900(-) Tm CDS//exon       -
chr6:31323198-31323199(-) m6A CDS//exon       26404942//27773535//27773536//22575960
chr6:31323214-31323215(-) m6A CDS//exon       26404942//27773535//27773536//22575960
chr6:31323219-31323220(-) m6A CDS//exon       26404942//27773535//27773536//22575960
chr6:31323236-31323237(-) m6A CDS//exon       26404942//27773535//27773536//22575960
chr6:31323243-31323244(-) m6A CDS//exon       26404942//27773535//27773536//22575960
chr6:31323248-31323249(-) m6A CDS//exon       26404942//27773535//27773536//22575960
chr6:31323357-31323358(-) m6A CDS//exon       27773536
chr6:31323368-31323369(-) m6A CDS//exon       27773536
chr6:31323542-31323543(-) m6A exon//intron       -
chr6:31323548-31323549(-) m6A exon//intron       -
chr6:31323960-31323961(-) m6A CDS//exon       27371828//27773536//22575960
chr6:31324080-31324081(-) m6A CDS//exon       24284625//27371828//27773536//22575960
chr6:31324090-31324091(-) m6A CDS//exon       24284625//27371828//27773536//22575960
chr6:31324104-31324105(-) m6A CDS//exon       24284625//27371828//27773536//22575960
chr6:31324246-31324247(-) m6A exon//intron       24284625//27371828//27773536//22575960
chr6:31324346-31324347(-) m6A exon//intron       27371828//27773536
chr6:31324356-31324357(-) m6A exon//intron       27371828//27773536
chr6:31324496-31324497(-) m6A CDS//exon       24981863//27371828//27773536
chr6:31324518-31324519(-) m6A CDS//exon       24981863//27371828//27773536
chr6:31324547-31324548(-) m6A CDS//exon       24981863//27371828//27773536
chr6:31324553-31324554(-) m6A CDS//exon       24284625//24981863//27371828//27773536//22575960
chr6:31324792-31324793(-) m6A CDS//intron       24284625//24981863//28052920//27371828//27773536
chr6:31324812-31324813(-) m6A CDS//intron       24284625//24981863//28052920//27371828//27773536
chr6:31324871-31324872(-) m6A 5'UTR//CDS//exon       25456834//24981863//28052920//27371828//27773536
chr6:31324913-31324914(-) m6A 5'UTR//CDS//exon       25456834//24981863//27371828//27773536
chr6:31324959-31324960(-) m6A 5'UTR       25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-222-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
HLA-B
Exosome Blood     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-222-5p
Interactor2: HLA-B

Evidence Support:


Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence DIANA//miRanda//PicTar//Targetscan
Support Database ViRBase

References:


PMID 31992777 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line TEC cells Interactor2 expression None
Description The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.

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