Detail Information

Basic Information:


  VIRBase ID:  

HHID00023469

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           CXCL8:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p CXCL8
miRBase
Accession/Entrez ID		 MIMAT0004512 3576
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GCP-1//GCP1//IL8//LECT//LUCT//LYNAP//MDNCF//MONAP//NAF//NAP-1//NAP1//SCYB8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CXCL8
chr4:74606289-74606290(+) m6A 5'UTR//exon       24981863//26404942
chr4:74606299-74606300(+) m6A 5'UTR//exon       24981863//26404942
chr4:74606324-74606325(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74606341-74606342(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74606354-74606355(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74606373-74606374(+) m6A 5'UTR//exon       24981863//26404942//27773535
chr4:74607286-74607287(+) m6A CDS//exon       27773535
chr4:74607308-74607309(+) m6A CDS//exon       27773535
chr4:74607319-74607320(+) m6A CDS//exon       26404942//27773535
chr4:74607346-74607347(+) m6A CDS//exon       26404942//27773535
chr4:74607367-74607368(+) m6A CDS//exon       26404942//27773535
chr4:74607434-74607435(+) m6A exon//intron       26404942
chr4:74608331-74608332(+) m6A 3'UTR       27773535
chr4:74608370-74608371(+) m6A 3'UTR       27773535
chr4:74608413-74608414(+) m6A 3'UTR       27773535
chr4:74608510-74608511(+) m6A 3'UTR       26404942//27773535
chr4:74608579-74608580(+) m6A 3'UTR       26404942//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
CXCL8
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: CXCL8

Evidence Support:


Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence DIANA//miRanda//PicTar//Targetscan
Support Database ViRBase

References:


PMID 31992777 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line TEC cells Interactor2 expression None
Description The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.

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