Detail Information

Basic Information:


  VIRBase ID:  

HHID00023468

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           BTK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p BTK
miRBase
Accession/Entrez ID		 MIMAT0004512 695
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AGMX1//AT//ATK//BPK//IGHD3//IMD1//PSCTK1//XLA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BTK
chrX:100606122(-) A-I      intronic
chrX:100639590(-) A-I      intronic
chrX:100639503(-) A-I      intronic
chrX:100639502(-) A-I      intronic
chrX:100639501(-) A-I      intronic
chrX:100639498(-) A-I      intronic
chrX:100635932(-) A-I      intronic
chrX:100635840(-) A-I      intronic
chrX:100627924(-) A-I      intronic
chrX:100627923(-) A-I      intronic
chrX:100619822(-) A-I      intronic
chrX:100618656(-) A-I      intronic
chrX:100607961(-) A-I      intronic
chrX:100607932(-) A-I      intronic
chrX:100607039(-) A-I      intronic
chrX:100606147(-) A-I      intronic
chrX:100606163(-) A-I      intronic
chrX:100606188(-) A-I      intronic
chrX:100607029(-) A-I      intronic
chrX:100606895(-) A-I      intronic
chrX:100606263(-) A-I      intronic
chrX:100606227(-) A-I      intronic
chrX:100605501(-) A-I      intronic
chrX:100606473(-) A-I      intronic
chrX:100619868(-) A-I      intronic
chrX:100619835(-) A-I      intronic
chrX:100627574(-) A-I      intronic
chrX:100606121(-) A-I      intronic
chrX:100605540(-) A-I      intronic
chrX:100606108(-) A-I      intronic
chrX:100605708(-) A-I      intronic
chrX:100605599(-) A-I      intronic
chrX:100605658(-) A-I      intronic
chrX:100607721(-) A-I      intronic
chrX:100605579(-) A-I      intronic
chrX:100605572(-) A-I      intronic
chrX:100606187(-) A-I      intronic
chrX:100605707(-) A-I      intronic
chrX:100607945(-) A-I      intronic
chrX:100605608(-) A-I      intronic
chrX:100627989(-) A-I      intronic
chrX:100635911(-) A-I      intronic
chrX:100605638(-) A-I      intronic
chrX:100606228(-) A-I      intronic
chrX:100610022(-) A-I      intronic
chrX:100607978(-) A-I      intronic
chrX:100606112(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BTK
chrX:100606121(-) A-G intron -    22484847
chrX:100606187(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BTK
chrX:100604521-100604522(-) m6A 3'UTR       28052920
chrX:100604643-100604644(-) m6A 3'UTR       28052920
chrX:100610722-100610723(-) m6A exon//intron       -
chrX:100610740-100610741(-) m6A exon//intron       -
chrX:100610749-100610750(-) m6A exon//intron       -
chrX:100611011-100611012(-) m6A exon//intron       -
chrX:100611033-100611034(-) m6A exon//intron       -
chrX:100611043-100611044(-) m6A CDS//exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
BTK
Chromatin K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: BTK

Evidence Support:


Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence DIANA//miRanda//PicTar//Targetscan
Support Database ViRBase

References:


PMID 31992777 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line TEC cells Interactor2 expression None
Description The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.

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