Detail Information

Basic Information:


  VIRBase ID:  

HHID00023466

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-92a-1-5p:           IL1A:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-92a-1-5p IL1A
miRBase
Accession/Entrez ID		 MIMAT0004507 3552
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IL-1 alpha//IL-1A//IL1//IL1-ALPHA//IL1F1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-92a-1-5p
rs1418785003 chr13:91351346    T/C
rs72631821 chr13:91351334    C/G
rs72631821 chr13:91351334    C/T
rs778492035 chr13:91351342    A/G
rs9589207 chr13:91351335    G/A
rs9589207 chr13:91351335    G/C
rs887397729 chr13:91351327    T/C

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IL1A
chr2:113538469(-) A-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL1A
chr2:113532275-113532276(-) m6A 3'UTR       24981863
chr2:113532289-113532290(-) m6A 3'UTR       24981863
chr2:113532318-113532319(-) m6A 3'UTR       24981863
chr2:113532360-113532361(-) m6A 3'UTR       24981863
chr2:113532391-113532392(-) m6A 3'UTR       24981863
chr2:113541330-113541331(-) m6A CDS       24981863
chr2:113542083-113542084(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-92a-1-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
IL1A
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-92a-1-5p
Curcumin 969516 Drug interaction    RC00006826
Diethylstilbestrol 448537 Drug interaction    RC00006825
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006824
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00006827
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-92a-1-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-92a-1-5p
Interactor2: IL1A

Evidence Support:


Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence DIANA//miRanda//PicTar//Targetscan
Support Database ViRBase

References:


PMID 31992777 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line TEC cells Interactor2 expression None
Description The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.

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