Basic Information:

  VIRBase ID:  

HHID00023453

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26b-3p:  MIMAT0004500          ASB2:  NM_001202429     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-26b-3p	ASB2
miRBase Accession/Entrez ID	MIMAT0004500	51676
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ASB-2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-26b-3p	rs373131632 chr2:218402710    G/A rs752111841 chr2:218402711    C/G rs752111841 chr2:218402711    C/T rs752183955 chr2:218402700    C/G rs757962316 chr2:218402701    C/T rs912863478 chr2:218402692    C/A rs912863478 chr2:218402692    C/T rs1233068699 chr2:218402699    T/G rs1354053050 chr2:218402695    GTT/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ASB2	chr14:94409963(-) A-I      intronic chr14:94409732(-) A-I      intronic chr14:94413362(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ASB2	chr14:94442844(-) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ASB2	chr14:94400606-94400607(-) m6A 3'UTR//exon       25456834//27371828 chr14:94400641-94400642(-) m6A 3'UTR//exon       25456834//27371828 chr14:94400733-94400734(-) m6A 3'UTR//exon       25456834//28052920//27371828 chr14:94400761-94400762(-) m6A 3'UTR//exon       25456834//28052920//27371828 chr14:94400780-94400781(-) m6A 3'UTR//exon       25456834//28052920//27371828 chr14:94400817-94400818(-) m6A 3'UTR//exon       25456834//28052920//27371828 chr14:94400873-94400874(-) m6A 3'UTR//exon       25456834//28052920//27371828 chr14:94400918-94400919(-) m6A 3'UTR//exon       25456834//28052920//27371828 chr14:94400966-94400967(-) m6A 3'UTR//exon       25456834//27371828 chr14:94401011-94401012(-) m6A CDS//exon       25456834 chr14:94401059-94401060(-) m6A CDS//exon       - chr14:94401067-94401068(-) m6A CDS//exon       - chr14:94401127-94401128(-) m6A CDS//exon       - chr14:94404069-94404070(-) m6A CDS//exon       - chr14:94404089-94404090(-) m6A CDS//exon       - chr14:94405580-94405581(-) m6A CDS//exon       - chr14:94405673-94405674(-) m6A CDS//exon       - chr14:94405685-94405686(-) m6A CDS//exon       - chr14:94413749-94413750(-) m6A CDS//intron       27371828 chr14:94417378-94417379(-) m6A CDS//intron       27371828 chr14:94417506-94417507(-) m6A CDS//intron       27371828 chr14:94417535-94417536(-) m6A CDS//intron       27371828 chr14:94419712-94419713(-) m6A CDS//intron       27371828 chr14:94419735-94419736(-) m6A CDS//intron       27371828 chr14:94419774-94419775(-) m6A CDS//intron       - chr14:94419811-94419812(-) m6A CDS//intron       - chr14:94419841-94419842(-) m6A CDS//intron       - chr14:94420620-94420621(-) m6A exon//intron       - chr14:94420773-94420774(-) m6A CDS//exon//intron       27371828 chr14:94420820-94420821(-) m6A CDS//exon//intron       27371828 chr14:94421468-94421469(-) m6A 5'UTR//intron       27371828 chr14:94421486-94421487(-) m6A 5'UTR//intron       27371828 chr14:94421532-94421533(-) m6A 5'UTR//intron       27371828 chr14:94421623-94421624(-) m6A 5'UTR//intron       27371828 chr14:94430758-94430759(-) m6A CDS//intron       - chr14:94430763-94430764(-) m6A CDS//intron       27371828 chr14:94430798-94430799(-) m6A CDS//intron       27371828 chr14:94442840-94442841(-) m6A 5'UTR//exon       - chr14:94442866-94442867(-) m6A 5'UTR//exon       - chr14:94442913-94442914(-) m6A 5'UTR//exon       - chr14:94442926-94442927(-) m6A 5'UTR//exon       - chr14:94442943-94442944(-) m6A 5'UTR//exon       - chr14:94443016-94443017(-) m6A 5'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-26b-3p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	ASB2	Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-26b-3p
Interactor2: ASB2

Evidence Support:

Weak-Evidence	RNA-Seq//Small RNA sequencing
Prediction-Evidence	DIANA//miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	31992777	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	TEC cells	Interactor2 expression	None
Description	The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.