Basic Information:

  VIRBase ID:  

HHID00023447

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-1-3p:  MIMAT0004489          HSPA5:  NM_005347     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-1-3p	HSPA5
miRBase Accession/Entrez ID	MIMAT0004489	3309
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BIP//GRP78//HEL-S-89n

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-1-3p	rs377111580 chr13:50048986    C/T rs769728617 chr13:50048992    CA/C rs1460126106 chr13:50049003    C/A rs1460126106 chr13:50049003    C/T rs1468155921 chr13:50049001    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HSPA5	chr9:128002058(-) A-I      intronic chr9:128000866(-) A-I      intronic chr9:128001986(-) A-I      intronic chr9:128001973(-) A-I      intronic chr9:128000939(-) A-I      NonSyn:Ile->Met chr9:128000938(-) A-I      NonSyn:Asn->Asp chr9:128000937(-) A-I      NonSyn:Asn->Ser chr9:128001923(-) A-I      intronic chr9:127997657(-) A-I      3'UTR chr9:127997694(-) A-I      3'UTR chr9:127997669(-) A-I      3'UTR chr9:127997663(-) A-I      3'UTR chr9:127997656(-) A-I      3'UTR chr9:127997650(-) A-I      3'UTR chr9:127997610(-) A-I      3'UTR chr9:127997632(-) A-I      3'UTR chr9:127997708(-) A-I      3'UTR chr9:127997701(-) A-I      3'UTR chr9:128000218(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HSPA5	chr9:127998403-127998404(-) m6A 3'UTR       24981863//27773535 chr9:127998461-127998462(-) m6A 3'UTR       27773535 chr9:127998641-127998642(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr9:127998748-127998749(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr9:127998797-127998798(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr9:127998823-127998824(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr9:127998831-127998832(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr9:127998869-127998870(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr9:127998936-127998937(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr9:127998969-127998970(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr9:127998991-127998992(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr9:127999058-127999059(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr9:127999080-127999081(-) m6A CDS       24209618//24981863//28052920//27773535//22575960//22608085 chr9:127999180-127999181(-) m6A CDS       24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr9:127999276-127999277(-) m6A CDS       24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr9:127999291-127999292(-) m6A CDS       24981863//26404942//27773535//22575960//22608085 chr9:128000936-128000937(-) m6A CDS       26404942 chr9:128000953-128000954(-) m6A CDS       26404942 chr9:128001265-128001266(-) m6A CDS       - chr9:128001354-128001355(-) m6A CDS       24981863//27773535//22575960 chr9:128001373-128001374(-) m6A CDS       24981863//27773535//22575960 chr9:128001411-128001412(-) m6A CDS       24981863//27773535//22575960 chr9:128001423-128001424(-) m6A CDS       24981863//27773535//22575960 chr9:128001445-128001446(-) m6A CDS       24981863//22575960 chr9:128001530-128001531(-) m6A CDS       22575960 chr9:128001559-128001560(-) m6A CDS       26404942//22575960 chr9:128001739-128001740(-) m6A CDS       26404942 chr9:128002976-128002977(-) m6A CDS       22575960 chr9:128003039-128003040(-) m6A CDS       22575960 chr9:128003063-128003064(-) m6A CDS       22575960 chr9:128003296-128003297(-) m6A CDS       22575960 chr9:128003340-128003341(-) m6A CDS       22575960 chr9:128003435-128003436(-) m6A 5'UTR       22575960 chr9:128003535-128003536(-) m6A 5'UTR       26404942//27773535//22575960 chr9:128003599-128003600(-) m6A 5'UTR       26404942//27773535//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	HSPA5	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-1-3p
Interactor2: HSPA5

Evidence Support:

Weak-Evidence	RNA-Seq//Small RNA sequencing
Prediction-Evidence	DIANA//miRanda//PicTar//Targetscan
Support Database	ViRBase

References:

PMID	31992777	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	TEC cells	Interactor2 expression	None
Description	The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.