Detail Information

Basic Information:


  VIRBase ID:  

HHID00023438

  Virus:  

Zika virus (strain RIO-U1,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-449a:           CAMK2B:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-449a CAMK2B
miRBase
Accession/Entrez ID		 MIMAT0001541 816
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CAM2//CAMK2//CAMKB//CaMKIIbeta//MRD54

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-449a
rs1294048688 chr5:55170588    C/A
rs749773363 chr5:55170591    C/G
rs780146909 chr5:55170586    A/G
rs913642990 chr5:55170597    A/G
rs987840066 chr5:55170596    A/G
rs755430105 chr5:55170602    C/G
rs779429211 chr5:55170603    T/G
rs933108375 chr5:55170605    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CAMK2B
chr7:44347562(-) A-I      intronic
chr7:44262218(-) A-I      intronic
chr7:44341219(-) A-I      intronic
chr7:44290234(-) A-I      intronic
chr7:44341009(-) A-I      intronic
chr7:44287565(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CAMK2B
chr7:44257125-44257126(-) m6A 3'UTR       -
chr7:44257147-44257148(-) m6A 3'UTR       22575960
chr7:44257189-44257190(-) m6A 3'UTR       22575960
chr7:44257200-44257201(-) m6A 3'UTR       22575960
chr7:44257220-44257221(-) m6A 3'UTR       22575960
chr7:44257250-44257251(-) m6A 3'UTR       22575960
chr7:44257263-44257264(-) m6A 3'UTR       22575960
chr7:44257278-44257279(-) m6A 3'UTR       22575960
chr7:44257289-44257290(-) m6A 3'UTR       22575960
chr7:44257303-44257304(-) m6A 3'UTR       22575960
chr7:44257308-44257309(-) m6A 3'UTR       22575960
chr7:44258758-44258759(-) m6A 3'UTR//intron       22608085
chr7:44258764-44258765(-) m6A 3'UTR//intron       22608085
chr7:44258774-44258775(-) m6A 3'UTR//intron       22608085
chr7:44258873-44258874(-) m6A 3'UTR//intron       22608085
chr7:44258882-44258883(-) m6A 3'UTR//intron       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-449a
Exosome Serum     18589210
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293)     22984580
CAMK2B
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-449a
Interactor2: CAMK2B

Evidence Support:


Weak-Evidence RNA-Seq//Small RNA sequencing
Prediction-Evidence DIANA//miRanda//PicTar//Targetscan
Support Database ViRBase

References:


PMID 31992777 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line TEC cells Interactor2 expression None
Description The microRNA-target network (Fig. 4b,c) revealed 13 upregulated microRNAs that can modulate the expression of 12 downregulated target transcripts.

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