Basic Information:

  VIRBase ID:  

HHID00023413

  Virus:  

Zika virus (strain PRVABC59,ZIKV)

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-331-5p:  MIMAT0004643          Xaf1:  NM_001037713     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-331-5p	Xaf1
miRBase Accession/Entrez ID	MIMAT0004643	327959
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	Fbox39

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Xaf1	chr11:72301646-72301647(+) m6A 5'UTR       25683224//24981863 chr11:72301705-72301706(+) m6A CDS//exon       25683224//24981863//25569111 chr11:72308608-72308609(+) m6A 3'UTR//CDS//exon       25456834//24981863 chr11:72308625-72308626(+) m6A 3'UTR//CDS//exon       25456834//24981863 chr11:72308688-72308689(+) m6A 3'UTR//CDS//exon       25456834//24981863//25569111//22608085 chr11:72308735-72308736(+) m6A 3'UTR//CDS//exon       25456834//24981863//25569111//22608085 chr11:72308748-72308749(+) m6A 3'UTR//CDS//exon       25456834//24981863//25569111 chr11:72308768-72308769(+) m6A CDS       25456834//24981863//25569111 chr11:72308776-72308777(+) m6A CDS       25456834//24981863//25569111 chr11:72308871-72308872(+) m6A CDS       24981863 chr11:72313279-72313280(+) m6A 3'UTR       24981863 chr11:72313332-72313333(+) m6A 3'UTR       24981863 chr11:72313391-72313392(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-331-5p	Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Exosome Bone marrow-derived macrophages     25159140

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-331-5p
Interactor2: Xaf1

Evidence Support:

Weak-Evidence	Nanodrop
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	30781519	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Furthermore, downregulation of miR-331-5p and miR-509-5p was inversely correlated to their predicted targets IL7, CD274, HLA-DRB5, XAF1, IL13RA1, TAP1, and CD80 (Figure 7C,D).