Basic Information:

  VIRBase ID:  

HHID00023408

  Virus:  

Zika virus (strain PRVABC59,ZIKV)

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-124-3p:  MIMAT0000134          Ccl2:  NM_011333     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-124-3p	Ccl2
miRBase Accession/Entrez ID	MIMAT0000134	20296
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	AI323594//HC11//JE//MCA//MCAF//MCP//MCP-//MCP-1//MCP1//Scy//Scya2//Sig//Sigje//SMC-C//SMC-CF

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Ccl2	chr11:82036649-82036650(+) m6A exon//intron       24981863 chr11:82036886-82036887(+) m6A exon//intron       24981863 chr11:82036891-82036892(+) m6A exon//intron       24981863 chr11:82036983-82036984(+) m6A CDS//exon       24981863 chr11:82036996-82036997(+) m6A CDS//exon       24981863 chr11:82037008-82037009(+) m6A CDS//exon       24981863 chr11:82037024-82037025(+) m6A CDS//exon       24981863 chr11:82037043-82037044(+) m6A CDS//exon       24981863//25569111 chr11:82037173-82037174(+) m6A CDS//exon       25683224//24981863//25569111 chr11:82037188-82037189(+) m6A 3'UTR//exon       25683224//24981863//25569111 chr11:82037213-82037214(+) m6A 3'UTR//exon       25683224//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-124-3p	Axon Motor neurons     30233312 Cell body Motor neurons     30233312 Cell body Neuron ball cultures     23897634 Dendrite Hippocampal neurons     24784359 Exosome Serum     28160157 Exosome BV2 microglial cells     31190315 Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Exosome Spinal motor neuron     32712030 Postsynaptic density ForeBrain     18410515 Synaptoneurosome ForeBrain     18410515
	Ccl2	Axon Motor neurons     24152552

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-124-3p
Interactor2: Ccl2

Evidence Support:

Weak-Evidence	Nanodrop
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	30781519	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	MiR-124-3p was the highest downregulated miRNA. Our data demonstrated increased expression of all the predicted targets of miR-124-3p including IL7, CCL2, LITAF, IRF1, and SBNO2 in ZIKV-infected neurons (Figure 7A).