Basic Information:

  VIRBase ID:  

HHID00023399

  Virus:  

Zika virus (strain MR766,ZIKV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-124-3p:  MIMAT0000422          TFRC:  NM_001313965     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-124-3p	TFRC
miRBase Accession/Entrez ID	MIMAT0000422	7037
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD71//IMD46//p90//T9//TFR//TFR1//TR//TRFR

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-124-3p	rs1256263272 chr8:9903400    T/C rs1482188536 chr8:9903410    C/A rs753437646 chr8:9903401    G/T rs759045572 chr8:9903402    G/T rs764861083 chr8:9903408    A/G rs759034202 chr8:64379220    G/A rs1364752547 chr20:63178563    G/A rs749909250 chr20:63178569    G/A rs1287398108 chr20:63178559    C/G rs34059726 chr20:63178555    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TFRC	chr3:195788444(-) A-I      intronic chr3:195806329(-) A-I      intronic chr3:195806357(-) A-I      intronic chr3:195806418(-) A-I      intronic chr3:195807288(-) A-I      intronic chr3:195807289(-) A-I      intronic chr3:195788426(-) A-I      intronic chr3:195784614(-) A-I      intronic chr3:195782787(-) A-I      intronic chr3:195779767(-) A-I      intronic chr3:195779739(-) A-I      intronic chr3:195779724(-) A-I      intronic chr3:195779576(-) A-I      intronic chr3:195779557(-) A-I      intronic chr3:195789285(-) A-I      intronic chr3:195798749(-) A-I      intronic chr3:195802795(-) A-I      intronic chr3:195779539(-) A-I      intronic chr3:195779531(-) A-I      intronic chr3:195779525(-) A-I      intronic chr3:195779500(-) A-I      intronic chr3:195803396(-) A-I      intronic chr3:195779494(-) A-I      intronic chr3:195779491(-) A-I      intronic chr3:195784545(-) A-I      intronic chr3:195779489(-) A-I      intronic chr3:195779482(-) A-I      intronic chr3:195779433(-) A-I      intronic chr3:195779423(-) A-I      intronic chr3:195804597(-) A-I      intronic chr3:195797396(-) A-I      intronic chr3:195797397(-) A-I      intronic chr3:195798631(-) A-I      intronic chr3:195803449(-) A-I      intronic chr3:195804560(-) A-I      intronic chr3:195803611(-) A-I      intronic chr3:195803557(-) A-I      intronic chr3:195802819(-) A-I      intronic chr3:195803506(-) A-I      intronic chr3:195803508(-) A-I      intronic chr3:195803523(-) A-I      intronic chr3:195807119(-) A-I      intronic chr3:195804264(-) A-I      intronic chr3:195804406(-) A-I      intronic chr3:195805380(-) A-I      intronic chr3:195805409(-) A-I      intronic chr3:195805416(-) A-I      intronic chr3:195802794(-) A-I      intronic chr3:195805751(-) A-I      intronic chr3:195788534(-) A-I      intronic chr3:195788554(-) A-I      intronic chr3:195788562(-) A-I      intronic chr3:195788579(-) A-I      intronic chr3:195788588(-) A-I      intronic chr3:195805428(-) A-I      intronic chr3:195805445(-) A-I      intronic chr3:195788611(-) A-I      intronic chr3:195805446(-) A-I      intronic chr3:195789186(-) A-I      intronic chr3:195789223(-) A-I      intronic chr3:195806291(-) A-I      intronic chr3:195805752(-) A-I      intronic chr3:195805673(-) A-I      intronic chr3:195805818(-) A-I      intronic chr3:195788612(-) A-I      intronic chr3:195789191(-) A-I      intronic chr3:195805838(-) A-I      intronic chr3:195776713(-) A-I      3'UTR chr3:195802734(-) A-I      intronic chr3:195803548(-) A-I      intronic chr3:195795946(-) A-I      intronic chr3:195802892(-) A-I      intronic chr3:195788632(-) A-I      intronic chr3:195807342(-) A-I      intronic chr3:195787475(-) A-I      intronic chr3:195779584(-) A-I      intronic chr3:195784605(-) A-I      intronic chr3:195805688(-) A-I      intronic chr3:195803507(-) A-I      intronic chr3:195779727(-) A-I      intronic chr3:195804248(-) A-I      intronic chr3:195797566(-) A-I      intronic chr3:195789304(-) A-I      intronic chr3:195802497(-) A-I      intronic chr3:195802926(-) A-I      intronic chr3:195789357(-) A-I      intronic chr3:195797375(-) A-I      intronic chr3:195802887(-) A-I      intronic chr3:195789007(-) A-I      intronic chr3:195804504(-) A-I      intronic chr3:195805672(-) A-I      intronic chr3:195779958(-) A-I      intronic chr3:195807274(-) A-I      intronic chr3:195803524(-) A-I      intronic chr3:195806363(-) A-I      intronic chr3:195781095(-) A-I      intronic chr3:195797374(-) A-I      intronic chr3:195807313(-) A-I      intronic chr3:195802927(-) A-I      intronic chr3:195805348(-) A-I      intronic chr3:195802861(-) A-I      intronic chr3:195788463(-) A-I      intronic chr3:195779516(-) A-I      intronic chr3:195779766(-) A-I      intronic chr3:195789256(-) A-I      intronic chr3:195789360(-) A-I      intronic chr3:195784539(-) A-I      intronic chr3:195779815(-) A-I      intronic chr3:195805753(-) A-I      intronic chr3:195807060(-) A-I      intronic chr3:195806266(-) A-I      intronic chr3:195788565(-) A-I      intronic chr3:195797789(-) A-I      intronic chr3:195789292(-) A-I      intronic chr3:195805872(-) A-I      intronic chr3:195782545(-) A-I      intronic chr3:195787425(-) A-I      intronic chr3:195786123(-) A-I      intronic chr3:195795373(-) A-I      intronic chr3:195807248(-) A-I      intronic chr3:195802962(-) A-I      intronic chr3:195783318(-) A-I      intronic chr3:195806402(-) A-I      intronic chr3:195797306(-) A-I      intronic chr3:195807139(-) A-I      intronic chr3:195807188(-) A-I      intronic chr3:195797544(-) A-I      intronic chr3:195779972(-) A-I      intronic chr3:195802740(-) A-I      intronic chr3:195804523(-) A-I      intronic chr3:195789322(-) A-I      intronic chr3:195788528(-) A-I      intronic chr3:195783403(-) A-I      intronic chr3:195802831(-) A-I      intronic chr3:195787480(-) A-I      intronic chr3:195789199(-) A-I      intronic chr3:195802796(-) A-I      intronic chr3:195788525(-) A-I      intronic chr3:195806286(-) A-I      intronic chr3:195788429(-) A-I      intronic chr3:195788466(-) A-I      intronic chr3:195802780(-) A-I      intronic chr3:195782960(-) A-I      intronic chr3:195805841(-) A-I      intronic chr3:195806361(-) A-I      intronic chr3:195797778(-) A-I      intronic chr3:195807191(-) A-I      intronic chr3:195779436(-) A-I      intronic chr3:195797584(-) A-I      intronic chr3:195789317(-) A-I      intronic chr3:195788489(-) A-I      intronic chr3:195789237(-) A-I      intronic chr3:195789295(-) A-I      intronic chr3:195802974(-) A-I      intronic chr3:195789403(-) A-I      intronic chr3:195788498(-) A-I      intronic chr3:195797300(-) A-I      intronic chr3:195795953(-) A-I      intronic chr3:195788543(-) A-I      intronic chr3:195797169(-) A-I      intronic chr3:195802957(-) A-I      intronic chr3:195779796(-) A-I      intronic chr3:195789321(-) A-I      intronic chr3:195789378(-) A-I      intronic chr3:195807343(-) A-I      intronic chr3:195788485(-) A-I      intronic chr3:195788375(-) A-I      intronic chr3:195806385(-) A-I      intronic chr3:195779585(-) A-I      intronic chr3:195797597(-) A-I      intronic chr3:195789272(-) A-I      intronic chr3:195783379(-) A-I      intronic chr3:195788446(-) A-I      intronic chr3:195804220(-) A-I      intronic chr3:195807323(-) A-I      intronic chr3:195805267(-) A-I      intronic chr3:195788418(-) A-I      intronic chr3:195802909(-) A-I      intronic chr3:195804618(-) A-I      intronic chr3:195805406(-) A-I      intronic chr3:195784630(-) A-I      intronic chr3:195788493(-) A-I      intronic chr3:195784590(-) A-I      intronic chr3:195786116(-) A-I      intronic chr3:195806448(-) A-I      intronic chr3:195779909(-) A-I      intronic chr3:195805827(-) A-I      intronic chr3:195788499(-) A-I      intronic chr3:195797557(-) A-I      intronic chr3:195803533(-) A-I      intronic chr3:195789246(-) A-I      intronic chr3:195788564(-) A-I      intronic chr3:195789231(-) A-I      intronic chr3:195789260(-) A-I      intronic chr3:195779773(-) A-I      intronic chr3:195807247(-) A-I      intronic chr3:195779903(-) A-I      intronic chr3:195797810(-) A-I      intronic chr3:195779863(-) A-I      intronic chr3:195784580(-) A-I      intronic chr3:195803213(-) A-I      intronic chr3:195789282(-) A-I      intronic chr3:195803280(-) A-I      intronic chr3:195797357(-) A-I      intronic chr3:195805858(-) A-I      intronic chr3:195779725(-) A-I      intronic chr3:195787413(-) A-I      intronic chr3:195805809(-) A-I      intronic chr3:195789240(-) A-I      intronic chr3:195807221(-) A-I      intronic chr3:195805743(-) A-I      intronic chr3:195795240(-) A-I      intronic chr3:195788598(-) A-I      intronic chr3:195789328(-) A-I      intronic chr3:195797232(-) A-I      intronic chr3:195788450(-) A-I      intronic chr3:195804501(-) A-I      intronic chr3:195789157(-) A-I      intronic chr3:195789280(-) A-I      intronic chr3:195789365(-) A-I      intronic chr3:195788458(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TFRC	chr3:195795946(-) A-I intron -    15545495 chr3:195784580(-) A-I intron -    22327324 chr3:195789198(-) A-I intron -    22327324 chr3:195789282(-) A-I intron -    22327324 chr3:195789360(-) A-I intron -    22327324 chr3:195797375(-) A-I intron -    22327324 chr3:195797566(-) A-I intron -    22327324 chr3:195797802(-) A-I intron -    21960545 chr3:195779436(-) A-G intron -    22484847 chr3:195779515(-) A-G intron -    22484847 chr3:195779516(-) A-G intron -    22484847 chr3:195779796(-) A-G intron -    22484847 chr3:195779815(-) A-G intron -    22484847 chr3:195779863(-) A-G intron -    22484847 chr3:195779902(-) A-G intron -    22484847 chr3:195779909(-) A-G intron -    22484847 chr3:195779941(-) A-G intron -    22484847 chr3:195779958(-) A-G intron -    22484847 chr3:195779972(-) A-G intron -    22484847 chr3:195781119(-) G-A intron -    22484847 chr3:195783786(-) T-C intron -    22484847 chr3:195784539(-) A-G intron -    22484847 chr3:195784580(-) A-G intron -    22484847 chr3:195784590(-) A-G intron -    22484847 chr3:195784630(-) A-G intron -    22484847 chr3:195784652(-) G-T intron -    22484847 chr3:195784670(-) G-T intron -    22484847 chr3:195785885(-) T-C intron -    22484847 chr3:195787425(-) A-G intron -    22484847 chr3:195787475(-) A-G intron -    22484847 chr3:195787480(-) A-G intron -    22484847 chr3:195788396(-) A-G intron -    22484847 chr3:195788418(-) A-G intron -    22484847 chr3:195788429(-) A-G intron -    22484847 chr3:195788450(-) A-G intron -    22484847 chr3:195788458(-) A-G intron -    22484847 chr3:195788463(-) A-G intron -    22484847 chr3:195788466(-) A-G intron -    22484847 chr3:195788485(-) A-G intron -    22484847 chr3:195788489(-) A-G intron -    22484847 chr3:195788493(-) A-G intron -    22484847 chr3:195788498(-) A-G intron -    22484847 chr3:195788499(-) A-G intron -    22484847 chr3:195788525(-) A-G intron -    22484847 chr3:195788528(-) A-G intron -    22484847 chr3:195788543(-) A-G intron -    22484847 chr3:195788564(-) A-G intron -    22484847 chr3:195788565(-) A-G intron -    22484847 chr3:195788593(-) A-G intron -    22484847 chr3:195788598(-) A-G intron -    22484847 chr3:195788607(-) A-G intron -    22484847 chr3:195788632(-) A-G intron -    22484847 chr3:195789157(-) A-G intron -    22484847 chr3:195789198(-) A-G intron -    22484847 chr3:195789199(-) A-G intron -    22484847 chr3:195789231(-) A-G intron -    22484847 chr3:195789237(-) A-G intron -    22484847 chr3:195789240(-) A-G intron -    22484847 chr3:195789246(-) A-G intron -    22484847 chr3:195789260(-) A-G intron -    22484847 chr3:195789272(-) A-G intron -    22484847 chr3:195789280(-) A-G intron -    22484847 chr3:195789282(-) A-G intron -    22484847 chr3:195789292(-) A-G intron -    22484847 chr3:195789295(-) A-G intron -    22484847 chr3:195789304(-) A-G intron -    22484847 chr3:195789317(-) A-G intron -    22484847 chr3:195789321(-) A-G intron -    22484847 chr3:195789322(-) A-G intron -    22484847 chr3:195789328(-) A-G intron -    22484847 chr3:195789357(-) A-G intron -    22484847 chr3:195789360(-) A-G intron -    22484847 chr3:195789365(-) A-G intron -    22484847 chr3:195789403(-) A-G intron -    22484847 chr3:195790641(-) C-T intron -    22484847 chr3:195790681(-) T-C intron -    22484847 chr3:195790773(-) G-T intron -    22484847 chr3:195795311(-) C-T intron -    22484847 chr3:195795946(-) A-G intron -    22484847 chr3:195795953(-) A-G intron -    22484847 chr3:195797374(-) A-G intron -    22484847 chr3:195797375(-) A-G intron -    22484847 chr3:195797557(-) A-G intron -    22484847 chr3:195797566(-) A-G intron -    22484847 chr3:195797802(-) A-G intron -    22484847 chr3:195801917(-) G-T intron -    22484847 chr3:195802796(-) A-G intron -    22484847 chr3:195802807(-) A-G intron -    22484847 chr3:195802861(-) A-G intron -    22484847 chr3:195802892(-) A-G intron -    22484847 chr3:195804372(-) A-G intron -    22484847 chr3:195804504(-) A-G intron -    22484847 chr3:195804523(-) A-G intron -    22484847 chr3:195804618(-) A-G intron -    22484847 chr3:195805348(-) A-G intron -    22484847 chr3:195805406(-) A-G intron -    22484847 chr3:195805514(-) A-G intron -    22484847 chr3:195805688(-) A-G intron -    22484847 chr3:195805743(-) A-G intron -    22484847 chr3:195805753(-) A-G intron -    22484847 chr3:195805809(-) A-G intron -    22484847 chr3:195805827(-) A-G intron -    22484847 chr3:195805841(-) A-G intron -    22484847 chr3:195805858(-) A-G intron -    22484847 chr3:195805872(-) A-G intron -    22484847 chr3:195805877(-) A-G intron -    22484847 chr3:195806266(-) A-G intron -    22484847 chr3:195806280(-) A-G intron -    22484847 chr3:195806286(-) A-G intron -    22484847 chr3:195806363(-) A-G intron -    22484847 chr3:195806373(-) A-G intron -    22484847 chr3:195806385(-) A-G intron -    22484847 chr3:195806402(-) A-G intron -    22484847 chr3:195806448(-) A-G intron -    22484847 chr3:195806482(-) A-G intron -    22484847 chr3:195807188(-) A-G intron -    22484847 chr3:195807191(-) A-G intron -    22484847 chr3:195807218(-) T-G intron -    22484847 chr3:195807221(-) A-G intron -    22484847 chr3:195807247(-) A-G intron -    22484847 chr3:195807274(-) A-G intron -    22484847 chr3:195807303(-) A-G intron -    22484847 chr3:195807323(-) A-G intron -    22484847 chr3:195807342(-) A-G intron -    22484847 chr3:195807343(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TFRC	chr3:195778721-195778722(-) m6A 3'UTR//intron       24284625//22575960//22608085 chr3:195778761-195778762(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:195778785-195778786(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr3:195778831-195778832(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr3:195778874-195778875(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr3:195778897-195778898(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr3:195778935-195778936(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr3:195778944-195778945(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr3:195778951-195778952(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr3:195780309-195780310(-) m6A CDS       24284625//22575960 chr3:195780332-195780333(-) m6A CDS       24284625//22575960 chr3:195780363-195780364(-) m6A CDS//exon       24284625 chr3:195782020-195782021(-) m6A CDS//exon       26404942//22575960 chr3:195782026-195782027(-) m6A CDS//exon       26404942//22575960 chr3:195782049-195782050(-) m6A CDS//exon       26404942//22575960 chr3:195782098-195782099(-) m6A CDS//exon       26404942//22575960 chr3:195782124-195782125(-) m6A CDS//exon       26404942//22575960 chr3:195782137-195782138(-) m6A CDS//exon       26404942//22575960 chr3:195787132-195787133(-) m6A exon//intron       - chr3:195789754-195789755(-) Tm CDS//exon       - chr3:195792436-195792437(-) m6A CDS       26404942 chr3:195792456-195792457(-) m6A CDS       26404942 chr3:195798329-195798330(-) m6A 3'UTR//CDS       22575960 chr3:195798360-195798361(-) m6A 3'UTR//CDS       22575960 chr3:195798876-195798877(-) m6A 3'UTR//CDS       22575960 chr3:195798926-195798927(-) m6A 3'UTR//CDS       22575960 chr3:195800818-195800819(-) m6A CDS//intron       22575960 chr3:195800827-195800828(-) m6A CDS//intron       22575960 chr3:195800832-195800833(-) m6A CDS//intron       22575960 chr3:195800890-195800891(-) m6A CDS//intron       24981863//26404942//22575960 chr3:195800914-195800915(-) Cm CDS//intron       - chr3:195800924-195800925(-) m6A CDS//intron       24981863//26404942//22575960 chr3:195800934-195800935(-) m6A CDS//intron       24981863//26404942//22575960 chr3:195800948-195800949(-) m6A CDS//intron       24981863//26404942//22575960 chr3:195800955-195800956(-) m6A CDS//intron       24981863//26404942//22575960 chr3:195802059-195802060(-) m6A CDS//exon//intron       24981863//26404942//27773535 chr3:195802093-195802094(-) m6A CDS//exon//intron       24981863//26404942//27773535 chr3:195802150-195802151(-) m6A CDS//exon//intron       24981863//27773535//22575960 chr3:195802219-195802220(-) m6A CDS//exon//intron       24284625//24209618//27773535//22575960 chr3:195808893-195808894(-) m6A 5'UTR//intron       24981863 chr3:195808988-195808989(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-124-3p	Exosome Plasma     23663360 Exosome Blood     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Blood|Fibroblasts|Urine     - Mitochondrion Cell line (HEK-293)     22984580
	TFRC	Chromatin HeLa-S3 cells|K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Endoplasmic reticulum U2OS cells     22679391 Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleolus K562 cells     - Nucleoplasm HeLa-S3 cells|K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-124-3p	N,N-Dimethyltryptamine 6089 Drug interaction    RC00002595 Estradiol 5757 Drug interaction    RC00002594 Vorinostat 5311 Drug interaction    RC00002593 Cocaine 446220 Drug interaction    RC00002602 Paroxetine 43815 Drug interaction    RC00002601 Methylphenidate 4158 Drug interaction    RC00002592 Methadone 4095 Drug interaction    RC00002591 Etoposide 36462 Drug interaction    RC00002600 Harmaline 3564 Drug interaction    RC00002603 Fluoxetine 3386 Drug interaction    RC00002590 Enoxacin 3229 Drug interaction    RC00002589 Doxorubicin 31703 Drug interaction    RC00002599 Desipramine 2995 Drug interaction    RC00002588 Camptothecin 24360 Drug interaction    RC00002598 Cobalt chloride (CoCl2) 24288 Drug interaction    RC00002597 N,N-Dimethyl-5-methoxytryptamine 1832 Drug interaction    RC00002587 Arsenic trioxide 14888 Drug interaction    RC00002596 IR - Drug interaction    RC00002604

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-124-3p	Doxorubicin 31703       30807260

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-124-3p
Interactor2: TFRC

Evidence Support:

Strong-Evidence	Dual glo luciferase assay//qRT-PCR
Weak-Evidence	MiRNA sequencing//RNA-Seq
Prediction-Evidence	miRanda//miRTarBase//Targetscan
Support Database	ViRBase

References:

PMID	31216479	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Human neuronal stem cells	Interactor2 expression	None
Description	Consistent with this, ZIKV infection upregulated miR-124-3p and downregulated TFRC mRNA in ZIKV-infected hNSCs and mouse brain tissue.