Detail Information

Basic Information:


  VIRBase ID:  

HHID00020863

  Virus:  

Japanese encephalitis virus (P3 strain)

  Host:  

Mus musculus

  Confidence Score:  

0.9026

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-326-3p:           TRIM25:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol mmu-miR-326-3p TRIM25
miRBase
Accession/Entrez ID		 MIMAT0000559 7706
Organism Mus musculus Mus musculus
Category miRNA mRNA
Alias - EFP//RNF147//Z147//ZNF147

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM25
chr17:54983917(-) A-I      intronic
chr17:54983310(-) A-I      intronic
chr17:54984137(-) A-I      intronic
chr17:54982581(-) A-I      intronic
chr17:54984144(-) A-I      intronic
chr17:54983127(-) A-I      intronic
chr17:54990368(-) A-I      intronic
chr17:54983238(-) A-I      intronic
chr17:54983262(-) A-I      intronic
chr17:54983101(-) A-I      intronic
chr17:54982662(-) A-I      intronic
chr17:54983993(-) A-I      intronic
chr17:54983951(-) A-I      intronic
chr17:54982577(-) A-I      intronic
chr17:54984059(-) A-I      intronic
chr17:54982601(-) A-I      intronic
chr17:54983995(-) A-I      intronic
chr17:54982585(-) A-I      intronic
chr17:54965860(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRIM25
chr17:54973875(-) C-T intron -    22484847
chr17:54982577(-) A-G intron -    22484847
chr17:54965860(-) A-G exon 3'UTR    22484847
chr17:54990654(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM25
chr17:54965284-54965285(-) m6A 3'UTR       28052920//27773535//22608085
chr17:54965340-54965341(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//22608085
chr17:54965350-54965351(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//22608085
chr17:54965456-54965457(-) m6A 3'UTR       24284625//24981863//28052920//22608085
chr17:54965463-54965464(-) m6A 3'UTR       24284625//24981863//28052920//22608085
chr17:54965475-54965476(-) m6A 3'UTR       24284625//24981863//28052920//22608085
chr17:54965528-54965529(-) m6A 3'UTR       24284625//24981863//22608085
chr17:54965590-54965591(-) m6A 3'UTR       24284625//24981863//22608085
chr17:54966028-54966029(-) m6A 3'UTR       -
chr17:54966062-54966063(-) m6A 3'UTR       -
chr17:54967981-54967982(-) m6A 3'UTR//exon       24284625
chr17:54968194-54968195(-) m6A 3'UTR//exon       24284625//24981863//22575960
chr17:54968394-54968395(-) m6A 3'UTR//exon       24284625
chr17:54968401-54968402(-) m6A 3'UTR//exon       24284625
chr17:54968499-54968500(-) m6A 3'UTR//exon       24284625//24981863
chr17:54968524-54968525(-) m6A 3'UTR//exon       24284625//24981863
chr17:54968581-54968582(-) m6A 3'UTR//exon       24284625
chr17:54968989-54968990(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr17:54969015-54969016(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr17:54969136-54969137(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22575960
chr17:54969251-54969252(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:54969352-54969353(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:54969391-54969392(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:54969493-54969494(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:54969568-54969569(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:54972719-54972720(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535
chr17:54972739-54972740(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535
chr17:54972771-54972772(-) m6A 3'UTR//CDS//exon       24284625//24209618//27773535
chr17:54972897-54972898(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535
chr17:54972915-54972916(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535
chr17:54973248-54973249(-) m6A exon//intron       24981863
chr17:54973290-54973291(-) m6A 3'UTR//CDS//exon       24981863
chr17:54976371-54976372(-) m6A exon//intron       24981863
chr17:54978838-54978839(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828
chr17:54978877-54978878(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54978882-54978883(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54978927-54978928(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54981654-54981655(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54981674-54981675(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54981773-54981774(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//27371828
chr17:54981838-54981839(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54985847-54985848(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54985906-54985907(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54989481-54989482(-) m6A CDS//intron       27371828
chr17:54989506-54989507(-) m6A CDS//intron       27371828
chr17:54989511-54989512(-) m6A CDS//intron       27371828
chr17:54990924-54990925(-) m6A CDS       24284625
chr17:54991152-54991153(-) m6A CDS       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate mmu-miR-326-3p
Exosome Mast cells     17486113
Exosome B6 BMDCs     22031862
Exosome Bone marrow-derived macrophages     25159140
TRIM25
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: mmu-miR-326-3p
Interactor2: TRIM25

Evidence Support:


Strong-Evidence Dual luciferase reporter assay//qPCR
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32552669 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line 293T cells//mouse microglia (BV2 cells) Interactor2 expression None
Description Furthermore, ectopic expression of miR-326-3p led to a markedly down-regulated expression of circ_0000220 and miR-326-3p-target mRNAs (BCL3, MK2, and TRIM25), determined through quantitative real-time PCR and dual-luciferase assay (Fig. 6e, f).

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