Basic Information:

  VIRBase ID:  

HHID00019800

  Virus:  

Japanese encephalitis virus (GP78 strain)

  Host:  

Mus musculus

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-let-7a-5p:  MIMAT0000521          Tlr7:  NM_001290756     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-let-7a-5p	Tlr7
miRBase Accession/Entrez ID	MIMAT0000521	170743
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Tlr7	chrX:167304934-167304935(-) m6A 3'UTR       24981863 chrX:167304970-167304971(-) m6A 3'UTR       24981863 chrX:167305094-167305095(-) m6A 3'UTR       24981863 chrX:167305108-167305109(-) m6A 3'UTR       24981863 chrX:167305180-167305181(-) m6A 3'UTR       24981863 chrX:167305308-167305309(-) m6A 3'UTR       24981863 chrX:167305343-167305344(-) m6A CDS       24981863 chrX:167305378-167305379(-) m6A CDS       24981863 chrX:167305467-167305468(-) m6A CDS       24981863 chrX:167305595-167305596(-) m6A CDS       24981863//22608085 chrX:167305628-167305629(-) m6A CDS       24981863//22608085 chrX:167305660-167305661(-) m6A CDS       24981863 chrX:167305677-167305678(-) m6A CDS       24981863 chrX:167305690-167305691(-) m6A CDS       24981863 chrX:167305719-167305720(-) m6A CDS       24981863 chrX:167305783-167305784(-) m6A CDS       24981863 chrX:167306192-167306193(-) m6A CDS       24981863 chrX:167306227-167306228(-) m6A CDS       24981863 chrX:167306371-167306372(-) m6A CDS       24981863 chrX:167306407-167306408(-) m6A CDS       24981863 chrX:167306554-167306555(-) m6A CDS       24981863 chrX:167306642-167306643(-) m6A CDS       24981863 chrX:167306689-167306690(-) m6A CDS       24981863 chrX:167306716-167306717(-) m6A CDS       24981863 chrX:167306842-167306843(-) m6A CDS       24981863 chrX:167306874-167306875(-) m6A CDS       24981863 chrX:167306891-167306892(-) m6A CDS       24981863 chrX:167306905-167306906(-) m6A CDS       24981863 chrX:167306958-167306959(-) m6A CDS       24981863 chrX:167306989-167306990(-) m6A CDS       24981863 chrX:167306996-167306997(-) m6A CDS       24981863 chrX:167307016-167307017(-) m6A CDS       24981863 chrX:167307052-167307053(-) m6A CDS       24981863 chrX:167307130-167307131(-) m6A CDS       24981863 chrX:167307140-167307141(-) m6A CDS       24981863 chrX:167307208-167307209(-) m6A CDS       24981863 chrX:167307216-167307217(-) m6A CDS       24981863 chrX:167307223-167307224(-) m6A CDS       24981863 chrX:167307234-167307235(-) m6A CDS       24981863 chrX:167307328-167307329(-) m6A CDS       24981863 chrX:167307517-167307518(-) m6A CDS       24981863 chrX:167307529-167307530(-) m6A CDS       24981863 chrX:167307534-167307535(-) m6A CDS       24981863 chrX:167307544-167307545(-) m6A CDS       24981863 chrX:167307553-167307554(-) m6A CDS       24981863 chrX:167307943-167307944(-) m6A CDS       24981863 chrX:167307962-167307963(-) m6A CDS       24981863 chrX:167307978-167307979(-) m6A CDS       24981863 chrX:167308078-167308079(-) m6A CDS       24981863 chrX:167308113-167308114(-) m6A CDS       24981863 chrX:167308131-167308132(-) m6A CDS       24981863 chrX:167308222-167308223(-) m6A CDS       24981863 chrX:167308330-167308331(-) m6A CDS       24981863 chrX:167308339-167308340(-) m6A CDS       24981863 chrX:167308391-167308392(-) m6A CDS       24981863 chrX:167308458-167308459(-) m6A CDS       24981863 chrX:167308469-167308470(-) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-let-7a-5p	Exosome Serum     28160157 Exosome B6 BMDCs     22031862 Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Mitochondrion Heart tissue (subsarcolemmal and interfibrillar)     26377859 Nucleus Liver cells     21862971

Interaction Network (The top 100 interactions):

Interactor1: mmu-let-7a-5p
Interactor2: Tlr7

Evidence Support:

Strong-Evidence	ISH//qRT-PCR
Support Database	ViRBase

References:

PMID	30556910	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Mouse Brain tissues	Interactor2 expression	None
Description	We also observed a significant reduction in let‐7a/b expression in TLR7 Mo‐treated mice brain as compared to both wild‐type and scrambled‐treated JEV‐infected brain (Fig. 3a).