Detail Information

Basic Information:


  VIRBase ID:  

HHID00019689

  Virus:  

Japanese encephalitis virus

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-124-3p:           SHC1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-124-3p SHC1
miRBase
Accession/Entrez ID		 MIMAT0000422 6464
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SHC//SHCA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-124-3p
rs1256263272 chr8:9903400    T/C
rs1482188536 chr8:9903410    C/A
rs753437646 chr8:9903401    G/T
rs759045572 chr8:9903402    G/T
rs764861083 chr8:9903408    A/G
rs759034202 chr8:64379220    G/A
rs1364752547 chr20:63178563    G/A
rs749909250 chr20:63178569    G/A
rs1287398108 chr20:63178559    C/G
rs34059726 chr20:63178555    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SHC1
chr1:154936769(-) A-I      NonSyn:Arg->Gly
chr1:154945824(-) A-I      intronic
chr1:154945924(-) A-I      intronic
chr1:154945948(-) A-I      intronic
chr1:154936829(-) A-I      NonSyn:Met->Val
chr1:154936807(-) A-I      NonSyn:Asn->Ser
chr1:154936820(-) A-I      NonSyn:Lys->Glu
chr1:154936794(-) A-I      Syn:Gln->Gln
chr1:154936819(-) A-I      NonSyn:Lys->Arg
chr1:154936755(-) A-I      Syn:Leu->Leu
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SHC1
chr1:154936819(-) A-I intron -    22327324
chr1:154937223(-) A-I intron -    21960545
chr1:154934788(-) T-C exon 3'UTR    21725310
chr1:154936755(-) A-G intron -    22484847
chr1:154936819(-) A-G intron -    22484847
chr1:154937141(-) A-G intron -    22484847
chr1:154937169(-) A-G intron -    22484847
chr1:154937197(-) A-G intron -    22484847
chr1:154937208(-) A-G intron -    22484847
chr1:154937223(-) A-G intron -    22484847
chr1:154937237(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SHC1
chr1:154934801-154934802(-) m6A 3'UTR       24284625//27773535//22608085
chr1:154934981-154934982(-) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085
chr1:154935038-154935039(-) m6A 3'UTR       24981863//26404942//22575960//22608085
chr1:154935059-154935060(-) m6A 3'UTR       24981863//26404942//22608085
chr1:154935068-154935069(-) m6A 3'UTR       24981863//26404942//22608085
chr1:154935101-154935102(-) m6A 3'UTR       24981863
chr1:154935269-154935270(-) m6A 3'UTR       27773535
chr1:154935315-154935316(-) m6A 3'UTR       27773535
chr1:154935346-154935347(-) m6A 3'UTR       27773535
chr1:154935361-154935362(-) m6A 3'UTR       27773535
chr1:154935609-154935610(-) m6A 3'UTR       24284625
chr1:154935853-154935854(-) m6A 3'UTR//exon       24284625//27773535
chr1:154935886-154935887(-) m6A 3'UTR//exon       24284625//27773535
chr1:154935920-154935921(-) m6A 3'UTR//exon       24284625//27773535
chr1:154935946-154935947(-) m6A 3'UTR//exon       24284625//27773535
chr1:154936078-154936079(-) m6A 3'UTR//exon       24284625//24981863//26404942
chr1:154936152-154936153(-) m6A 3'UTR//exon       24284625//24981863//26404942
chr1:154936210-154936211(-) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085
chr1:154936284-154936285(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr1:154936314-154936315(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr1:154936348-154936349(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085
chr1:154936400-154936401(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22575960
chr1:154938435-154938436(-) m6A CDS       24284625
chr1:154938504-154938505(-) m6A CDS       24284625//27773535
chr1:154938510-154938511(-) m6A CDS       24284625//27773535
chr1:154938665-154938666(-) m6A CDS       24284625//27773535
chr1:154938698-154938699(-) m6A CDS       24284625//27773535
chr1:154938820-154938821(-) m6A CDS       24284625//27773535
chr1:154938882-154938883(-) m6A CDS       24284625//27773535//22575960
chr1:154938905-154938906(-) m6A CDS       24284625//27773535//22575960
chr1:154940166-154940167(-) m6A CDS       24284625//27773535//22575960
chr1:154940176-154940177(-) m6A CDS       24284625//27773535//22575960
chr1:154940190-154940191(-) m6A CDS       24284625//27773535
chr1:154940472-154940473(-) m6A CDS       27773535
chr1:154940973-154940974(-) m6A CDS       24284625//27773535
chr1:154940980-154940981(-) m6A CDS       24284625//27773535
chr1:154941866-154941867(-) m6A CDS//intron       24284625//24209618//27773535
chr1:154941880-154941881(-) m6A CDS//intron       24284625//24209618//27773535
chr1:154942531-154942532(-) m6A CDS//intron       24284625//24209618//25456834//27371828//22575960
chr1:154942599-154942600(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr1:154942638-154942639(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chr1:154942667-154942668(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chr1:154942673-154942674(-) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chr1:154942700-154942701(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chr1:154943049-154943050(-) m6A 5'UTR//intron       24284625//24209618//24981863//22575960
chr1:154943128-154943129(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960
chr1:154943183-154943184(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960
chr1:154945781-154945782(-) m6A 5'UTR//intron       24284625//25456834//24981863
chr1:154946738-154946739(-) m6A 5'UTR       24284625//24209618//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-124-3p
Exosome Plasma     23663360
Exosome Blood     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Fibroblasts|Urine     -
Mitochondrion Cell line (HEK-293)     22984580
SHC1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-124-3p
N,N-Dimethyltryptamine 6089 Drug interaction    RC00002595
Estradiol 5757 Drug interaction    RC00002594
Vorinostat 5311 Drug interaction    RC00002593
Cocaine 446220 Drug interaction    RC00002602
Paroxetine 43815 Drug interaction    RC00002601
Methylphenidate 4158 Drug interaction    RC00002592
Methadone 4095 Drug interaction    RC00002591
Etoposide 36462 Drug interaction    RC00002600
Harmaline 3564 Drug interaction    RC00002603
Fluoxetine 3386 Drug interaction    RC00002590
Enoxacin 3229 Drug interaction    RC00002589
Doxorubicin 31703 Drug interaction    RC00002599
Desipramine 2995 Drug interaction    RC00002588
Camptothecin 24360 Drug interaction    RC00002598
Cobalt chloride (CoCl2) 24288 Drug interaction    RC00002597
N,N-Dimethyl-5-methoxytryptamine 1832 Drug interaction    RC00002587
Arsenic trioxide 14888 Drug interaction    RC00002596
IR - Drug interaction    RC00002604
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-124-3p
Doxorubicin 31703       30807260

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-124-3p
Interactor2: SHC1

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence miRNA array
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31578247 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line hNPC cells//hNS1 cells Interactor2 expression Upregulation
Description FIG 8.qRT-PCR showing miR-124-3p target gene expression in hNS1 cells upon JEV infection and miR mimic transfection. FIG S5.Effect of miR-124-3p inhibitor treatment on target gene expression in hNS1 cells.

Starting a new search, please wait ...