Basic Information:

  VIRBase ID:  

HHID00019561

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 2a,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9810

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-501-3p:  MIMAT0004774          OGT:  NM_181673     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-501-3p	OGT
miRBase Accession/Entrez ID	MIMAT0004774	8473
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HINCUT-1//HRNT1//MRX106//O-GLCNAC//OGT1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-501-3p	rs112489955 chrX:50009781    G/A rs112489955 chrX:50009781    G/T rs1557182212 chrX:50009793    T/C rs376696825 chrX:50009787    G/A rs376696825 chrX:50009787    G/T rs781947379 chrX:50009780    C/T rs782814071 chrX:50009784    C/T rs149912461 chrX:50009773    A/G rs1557182197 chrX:50009774    T/C rs367629841 chrX:50009778    C/T rs782056456 chrX:50009775    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OGT	chrX:70784845(+) A-I      intronic chrX:70784848(+) A-I      intronic chrX:70790773(+) A-I      intronic chrX:70769095(+) A-I      intronic chrX:70771961(+) A-I      intronic chrX:70792363(+) A-I      intronic chrX:70791818(+) A-I      intronic chrX:70791786(+) A-I      intronic chrX:70790912(+) A-I      intronic chrX:70790857(+) A-I      intronic chrX:70790851(+) A-I      intronic chrX:70771951(+) A-I      intronic chrX:70771887(+) A-I      intronic chrX:70771965(+) A-I      intronic chrX:70771978(+) A-I      intronic chrX:70769096(+) A-I      intronic chrX:70769375(+) A-I      intronic chrX:70769493(+) A-I      intronic chrX:70771262(+) A-I      intronic chrX:70771320(+) A-I      intronic chrX:70771321(+) A-I      intronic chrX:70771322(+) A-I      intronic chrX:70771323(+) A-I      intronic chrX:70771439(+) A-I      intronic chrX:70790770(+) A-I      intronic chrX:70790675(+) A-I      intronic chrX:70790132(+) A-I      intronic chrX:70789991(+) A-I      intronic chrX:70789952(+) A-I      intronic chrX:70789947(+) A-I      intronic chrX:70789528(+) A-I      intronic chrX:70771993(+) A-I      intronic chrX:70772025(+) A-I      intronic chrX:70772262(+) A-I      intronic chrX:70772368(+) A-I      intronic chrX:70790783(+) A-I      intronic chrX:70772414(+) A-I      intronic chrX:70772496(+) A-I      intronic chrX:70784851(+) A-I      intronic chrX:70771803(+) A-I      intronic chrX:70792566(+) A-I      intronic chrX:70792542(+) A-I      intronic chrX:70784878(+) A-I      intronic chrX:70785095(+) A-I      intronic chrX:70785216(+) A-I      intronic chrX:70785255(+) A-I      intronic chrX:70785313(+) A-I      intronic chrX:70772497(+) A-I      intronic chrX:70779952(+) A-I      intronic chrX:70779964(+) A-I      intronic chrX:70785340(+) A-I      intronic chrX:70785342(+) A-I      intronic chrX:70788567(+) A-I      intronic chrX:70788571(+) A-I      intronic chrX:70788599(+) A-I      intronic chrX:70788610(+) A-I      intronic chrX:70788635(+) A-I      intronic chrX:70788902(+) A-I      intronic chrX:70788924(+) A-I      intronic chrX:70785314(+) A-I      intronic chrX:70785301(+) A-I      intronic chrX:70775357(+) A-I      intronic chrX:70775346(+) A-I      intronic chrX:70769489(+) A-I      intronic chrX:70769486(+) A-I      intronic chrX:70769454(+) A-I      intronic chrX:70769458(+) A-I      intronic chrX:70768953(+) A-I      intronic chrX:70772378(+) A-I      intronic chrX:70772404(+) A-I      intronic chrX:70768930(+) A-I      intronic chrX:70768886(+) A-I      intronic chrX:70792523(+) A-I      intronic chrX:70792466(+) A-I      intronic chrX:70792440(+) A-I      intronic chrX:70792429(+) A-I      intronic chrX:70792377(+) A-I      intronic chrX:70775381(+) A-I      intronic chrX:70779968(+) A-I      intronic chrX:70786948(+) A-I      intronic chrX:70792596(+) A-I      intronic chrX:70786945(+) A-I      intronic chrX:70786943(+) A-I      intronic chrX:70786934(+) A-I      intronic chrX:70786901(+) A-I      intronic chrX:70786899(+) A-I      intronic chrX:70786894(+) A-I      intronic chrX:70786890(+) A-I      intronic chrX:70786827(+) A-I      intronic chrX:70786806(+) A-I      intronic chrX:70785609(+) A-I      intronic chrX:70785606(+) A-I      intronic chrX:70785604(+) A-I      intronic chrX:70775322(+) A-I      intronic chrX:70785600(+) A-I      intronic chrX:70768893(+) A-I      intronic chrX:70768905(+) A-I      intronic chrX:70768955(+) A-I      intronic chrX:70785583(+) A-I      intronic chrX:70768973(+) A-I      intronic chrX:70775310(+) A-I      intronic chrX:70785550(+) A-I      intronic chrX:70785579(+) A-I      intronic chrX:70786942(+) A-I      intronic chrX:70768974(+) A-I      intronic chrX:70768992(+) A-I      intronic chrX:70769092(+) A-I      intronic chrX:70779972(+) A-I      intronic chrX:70780035(+) A-I      intronic chrX:70780073(+) A-I      intronic chrX:70780074(+) A-I      intronic chrX:70780829(+) A-I      intronic chrX:70780839(+) A-I      intronic chrX:70780852(+) A-I      intronic chrX:70780878(+) A-I      intronic chrX:70780958(+) A-I      intronic chrX:70781294(+) A-I      intronic chrX:70781298(+) A-I      intronic chrX:70788925(+) A-I      intronic chrX:70788933(+) A-I      intronic chrX:70789001(+) A-I      intronic chrX:70789012(+) A-I      intronic chrX:70789015(+) A-I      intronic chrX:70789057(+) A-I      intronic chrX:70789063(+) A-I      intronic chrX:70789067(+) A-I      intronic chrX:70784743(+) A-I      intronic chrX:70784751(+) A-I      intronic chrX:70771952(+) A-I      intronic chrX:70785261(+) A-I      intronic chrX:70784847(+) A-I      intronic chrX:70789392(+) A-I      intronic chrX:70784735(+) A-I      intronic chrX:70772503(+) A-I      intronic chrX:70789453(+) A-I      intronic chrX:70784913(+) A-I      intronic chrX:70785341(+) A-I      intronic chrX:70791759(+) A-I      intronic chrX:70785170(+) A-I      intronic chrX:70785347(+) A-I      intronic chrX:70784846(+) A-I      intronic chrX:70789686(+) A-I      intronic chrX:70785276(+) A-I      intronic chrX:70789084(+) A-I      intronic chrX:70788930(+) A-I      intronic chrX:70785194(+) A-I      intronic chrX:70771974(+) A-I      intronic chrX:70779877(+) A-I      intronic chrX:70771882(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OGT	chrX:70772332(+) A-I intron -    22327324 chrX:70772339(+) A-I intron -    22327324 chrX:70784846(+) A-I intron -    22327324 chrX:70784847(+) A-I intron -    22327324 chrX:70785170(+) A-I intron -    22327324 chrX:70785597(+) A-I intron -    22327324 chrX:70786802(+) A-I intron -    22327324 chrX:70786866(+) A-I intron -    22327324 chrX:70786889(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OGT	chrX:70752961-70752962(+) m6A 5'UTR//exon       24284625//24981863//22608085 chrX:70753109-70753110(+) m6A 5'UTR//exon       24284625//24981863//22575960 chrX:70764501-70764502(+) m6A exon//intron       22608085 chrX:70764511-70764512(+) m6A exon//intron       22608085 chrX:70764528-70764529(+) m6A exon//intron       24981863//22608085 chrX:70764579-70764580(+) m6A exon//intron       24981863//26404942//27773535//22608085 chrX:70764592-70764593(+) m6A exon//intron       24284625//24981863//26404942//27773535//22608085 chrX:70764602-70764603(+) m6A exon//intron       24284625//24981863//26404942//27773535//22608085 chrX:70764681-70764682(+) m6A exon//intron       24284625//24981863//26404942//22575960//22608085 chrX:70764687-70764688(+) m6A exon//intron       24284625//24981863//26404942//22575960//22608085 chrX:70764715-70764716(+) m6A exon//intron       24284625//24981863//26404942//22575960//22608085 chrX:70764829-70764830(+) m6A exon//intron       24284625//24981863//26404942//22608085 chrX:70765029-70765030(+) m6A exon//intron       24284625 chrX:70767261-70767262(+) m6A exon//intron       26404942 chrX:70767290-70767291(+) m6A exon//intron       26404942 chrX:70767331-70767332(+) m6A exon//intron       26404942 chrX:70767345-70767346(+) m6A exon//intron       26404942 chrX:70767362-70767363(+) m6A exon//intron       26404942 chrX:70767401-70767402(+) m6A exon//intron       26404942 chrX:70783200-70783201(+) m6A CDS//exon       27773535 chrX:70783291-70783292(+) m6A CDS//exon       26404942 chrX:70783333-70783334(+) m6A CDS//exon       26404942 chrX:70783346-70783347(+) Cm CDS//exon       - chrX:70787666-70787667(+) m6A exon//intron       - chrX:70787847-70787848(+) m6A CDS//exon       24284625 chrX:70787914-70787915(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chrX:70787932-70787933(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chrX:70787952-70787953(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793532-70793533(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793547-70793548(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793598-70793599(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793650-70793651(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793705-70793706(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793789-70793790(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793815-70793816(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793831-70793832(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793838-70793839(+) Y 3'UTR//exon       26075521 chrX:70794133-70794134(+) m6A 3'UTR//exon       24284625//24981863//22608085 chrX:70794153-70794154(+) m6A 3'UTR//exon       24284625//24981863//22608085 chrX:70794188-70794189(+) m6A 3'UTR//exon       24284625//24981863//22608085 chrX:70794392-70794393(+) Y 3'UTR//exon       26075521 chrX:70794821-70794822(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794865-70794866(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794899-70794900(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794917-70794918(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794987-70794988(+) m6A 3'UTR       24284625//26404942 chrX:70795176-70795177(+) m6A 3'UTR       26404942 chrX:70795244-70795245(+) m6A 3'UTR       24284625//26404942 chrX:70795265-70795266(+) m6A 3'UTR       24284625//26404942 chrX:70795380-70795381(+) m6A 3'UTR       24284625//26404942 chrX:70795500-70795501(+) m6A 3'UTR       24284625//26404942 chrX:70795588-70795589(+) m6A 3'UTR       24284625//27773535 chrX:70795624-70795625(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-501-3p	Exosome Primary dendritic cells     21505438 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Blood     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Myotube     27396686 Mitochondrion Skeletal muscle cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	OGT	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-501-3p	Cisplatin 5702198       30221699

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-501-3p
Interactor2: OGT

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//RT-qPCR//Western blot
Weak-Evidence	TaqMan Gene Expression Assay
Prediction-Evidence	DIANA//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31076402	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Huh7.5.1 cells	Interactor2 expression	None
Description	Co-transfection of miR-501-3p mimic with the wild-type 3'UTR reporter (RLuc wt OGT 3'UTR) significantly decreased luciferase activity as compared with the empty vector (figure 3C, p<0.05, t-test).