Basic Information:

  VIRBase ID:  

HHID00019505

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-215-3p:  MIMAT0026476          ZNF684:  NM_152373     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-215-3p	ZNF684
miRBase Accession/Entrez ID	MIMAT0026476	127396
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-215-3p	rs1333471638 chr1:220117882    G/A rs749489380 chr1:220117883    C/G rs754286532 chr1:220117889    GA/G rs1345487830 chr1:220117895    A/G rs757646667 chr1:220117893    TGACA/T rs768393822 chr1:220117898    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF684	chr1:40999730(+) A-I      intronic chr1:40999731(+) A-I      intronic chr1:41000409(+) A-I      intronic chr1:41000450(+) A-I      intronic chr1:41000455(+) A-I      intronic chr1:41000483(+) A-I      intronic chr1:41000554(+) A-I      intronic chr1:41000585(+) A-I      intronic chr1:41003247(+) A-I      intronic chr1:41003330(+) A-I      intronic chr1:41003335(+) A-I      intronic chr1:41003364(+) A-I      intronic chr1:41004725(+) A-I      intronic chr1:40999589(+) A-I      intronic chr1:40999637(+) A-I      intronic chr1:41004657(+) A-I      intronic chr1:41003767(+) A-I      intronic chr1:41005095(+) A-I      intronic chr1:41004900(+) A-I      intronic chr1:41004883(+) A-I      intronic chr1:41010141(+) A-I      NonSyn:Gln->Arg chr1:41000426(+) A-I      intronic chr1:41000526(+) A-I      intronic chr1:41005080(+) A-I      intronic chr1:41004908(+) A-I      intronic chr1:41003704(+) A-I      intronic chr1:41006618(+) A-I      intronic chr1:41004627(+) A-I      intronic chr1:41000407(+) A-I      intronic chr1:41006638(+) A-I      intronic chr1:41000538(+) A-I      intronic chr1:41004683(+) A-I      intronic chr1:41004315(+) A-I      intronic chr1:41005049(+) A-I      intronic chr1:41004963(+) A-I      intronic chr1:41000566(+) A-I      intronic chr1:40999625(+) A-I      intronic chr1:41007117(+) A-I      intronic chr1:41000610(+) A-I      intronic chr1:41003150(+) A-I      intronic chr1:41004351(+) A-I      intronic chr1:41003321(+) A-I      intronic chr1:41004397(+) A-I      intronic chr1:41003236(+) A-I      intronic chr1:41003250(+) A-I      intronic chr1:41000544(+) A-I      intronic chr1:41004409(+) A-I      intronic chr1:41000590(+) A-I      intronic chr1:40999661(+) A-I      intronic chr1:41004400(+) A-I      intronic chr1:41004886(+) A-I      intronic chr1:41004831(+) A-I      intronic chr1:41006586(+) A-I      intronic chr1:40999565(+) A-I      intronic chr1:41004479(+) A-I      intronic chr1:41000622(+) A-I      intronic chr1:41004413(+) A-I      intronic chr1:41003226(+) A-I      intronic chr1:41000518(+) A-I      intronic chr1:41004604(+) A-I      intronic chr1:40999613(+) A-I      intronic chr1:41007062(+) A-I      intronic chr1:41006511(+) A-I      intronic chr1:41003294(+) A-I      intronic chr1:41000431(+) A-I      intronic chr1:41003764(+) A-I      intronic chr1:41003712(+) A-I      intronic chr1:41006539(+) A-I      intronic chr1:41005112(+) A-I      intronic chr1:41006997(+) A-I      intronic chr1:41000557(+) A-I      intronic chr1:40999549(+) A-I      intronic chr1:41006538(+) A-I      intronic chr1:41004591(+) A-I      intronic chr1:41004393(+) A-I      intronic chr1:41006906(+) A-I      intronic chr1:41006985(+) A-I      intronic chr1:41004819(+) A-I      intronic chr1:41001945(+) A-I      intronic chr1:41001955(+) A-I      intronic chr1:41005170(+) A-I      intronic chr1:41006995(+) A-I      intronic chr1:41004733(+) A-I      intronic chr1:41004483(+) A-I      intronic chr1:41003757(+) A-I      intronic chr1:41001899(+) A-I      intronic chr1:41006488(+) A-I      intronic chr1:41003939(+) A-I      intronic chr1:41005109(+) A-I      intronic chr1:41005076(+) A-I      intronic chr1:41004802(+) A-I      intronic chr1:41003708(+) A-I      intronic chr1:41003765(+) A-I      intronic chr1:41004605(+) A-I      intronic chr1:41004370(+) A-I      intronic chr1:40999662(+) A-I      intronic chr1:41000604(+) A-I      intronic chr1:41006482(+) A-I      intronic chr1:41005059(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF684	chr1:41006482(+) A-I intron -    15258596 chr1:41006538(+) A-I intron -    15258596 chr1:41006539(+) A-I intron -    15258596 chr1:40999495(+) C-T intron -    22484847 chr1:40999549(+) A-G intron -    22484847 chr1:40999565(+) A-G intron -    22484847 chr1:40999613(+) A-G intron -    22484847 chr1:40999625(+) A-G intron -    22484847 chr1:40999661(+) A-G intron -    22484847 chr1:40999662(+) A-G intron -    22484847 chr1:41000431(+) A-G intron -    22484847 chr1:41000518(+) A-G intron -    22484847 chr1:41000622(+) A-G intron -    22484847 chr1:41001899(+) A-G intron -    22484847 chr1:41001945(+) A-G intron -    22484847 chr1:41001955(+) A-G intron -    22484847 chr1:41003764(+) A-G intron -    22484847 chr1:41004351(+) A-G intron -    22484847 chr1:41004393(+) A-G intron -    22484847 chr1:41004409(+) A-G intron -    22484847 chr1:41004413(+) A-G intron -    22484847 chr1:41004831(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF684	chr1:41012258-41012259(+) m6A CDS//exon       22608085 chr1:41012284-41012285(+) m6A CDS//exon       22608085 chr1:41012428-41012429(+) m6A CDS//exon       24981863//22608085 chr1:41012522-41012523(+) m6A CDS//exon       24981863//22608085 chr1:41012549-41012550(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr1:41012633-41012634(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr1:41012699-41012700(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr1:41012745-41012746(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr1:41012758-41012759(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr1:41012829-41012830(+) m6A CDS//exon       24284625//22608085 chr1:41012858-41012859(+) m6A CDS//exon       22608085 chr1:41012885-41012886(+) m6A CDS//exon       22608085 chr1:41012969-41012970(+) m6A CDS//exon       22608085 chr1:41013255-41013256(+) m6A 3'UTR//exon       24981863//22608085 chr1:41013292-41013293(+) m6A 3'UTR//exon       24981863//22608085 chr1:41013318-41013319(+) m6A 3'UTR//exon       24981863//22608085 chr1:41013378-41013379(+) m6A 3'UTR//exon       22608085 chr1:41013388-41013389(+) m6A 3'UTR//exon       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-215-3p	Exosome HCC cell line (Hep3B|HepG2|PLC/PRF/5)     21721029 Exosome Ovarian follicular fluid     22116803 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	ZNF684	Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-215-3p
Interactor2: ZNF684

Evidence Support:

Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	29749134	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Therefore, the miRNA target prediction tool Targetscan was used to search for the potential targets of miR-215.