Basic Information:

  VIRBase ID:  

HHID00019501

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-215-3p:  MIMAT0026476          TRIM22:  NM_001199573     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-215-3p	TRIM22
miRBase Accession/Entrez ID	MIMAT0026476	10346
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GPSTAF50//RNF94//STAF50

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-215-3p	rs1333471638 chr1:220117882    G/A rs749489380 chr1:220117883    C/G rs754286532 chr1:220117889    GA/G rs1345487830 chr1:220117895    A/G rs757646667 chr1:220117893    TGACA/T rs768393822 chr1:220117898    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRIM22	chr11:5721989(+) A-I      intronic chr11:5722011(+) A-I      intronic chr11:5721427(+) A-I      intronic chr11:5722015(+) A-I      intronic chr11:5721439(+) A-I      intronic chr11:5720660(+) A-I      intronic chr11:5721926(+) A-I      intronic chr11:5721946(+) A-I      intronic chr11:5721965(+) A-I      intronic chr11:5722028(+) A-I      intronic chr11:5720741(+) A-I      intronic chr11:5728802(+) A-I      intronic chr11:5720683(+) A-I      intronic chr11:5714695(+) A-I      intronic chr11:5714245(+) A-I      intronic chr11:5722009(+) A-I      intronic chr11:5721619(+) A-I      intronic chr11:5721606(+) A-I      intronic chr11:5714248(+) A-I      intronic chr11:5720577(+) A-I      intronic chr11:5720675(+) A-I      intronic chr11:5720601(+) A-I      intronic chr11:5720602(+) A-I      intronic chr11:5720603(+) A-I      intronic chr11:5720607(+) A-I      intronic chr11:5721607(+) A-I      intronic chr11:5721422(+) A-I      intronic chr11:5721528(+) A-I      intronic chr11:5714235(+) A-I      intronic chr11:5714242(+) A-I      intronic chr11:5720666(+) A-I      intronic chr11:5714247(+) A-I      intronic chr11:5714858(+) A-I      intronic chr11:5714894(+) A-I      intronic chr11:5714902(+) A-I      intronic chr11:5721414(+) A-I      intronic chr11:5720505(+) A-I      intronic chr11:5720567(+) A-I      intronic chr11:5720570(+) A-I      intronic chr11:5721534(+) A-I      intronic chr11:5722037(+) A-I      intronic chr11:5713952(+) A-I      intronic chr11:5714701(+) A-I      intronic chr11:5721525(+) A-I      intronic chr11:5721944(+) A-I      intronic chr11:5714175(+) A-I      intronic chr11:5723325(+) A-I      intronic chr11:5721446(+) A-I      intronic chr11:5714772(+) A-I      intronic chr11:5714696(+) A-I      intronic chr11:5713956(+) A-I      intronic chr11:5720500(+) A-I      intronic chr11:5714832(+) A-I      intronic chr11:5729067(+) A-I      intronic chr11:5721529(+) A-I      intronic chr11:5721484(+) A-I      intronic chr11:5721621(+) A-I      intronic chr11:5721613(+) A-I      intronic chr11:5720499(+) A-I      intronic chr11:5721542(+) A-I      intronic chr11:5714391(+) A-I      intronic chr11:5721945(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRIM22	chr11:5719034(+) A-I intron -    15258596 chr11:5719095(+) A-I intron -    15258596 chr11:5719257(+) A-I intron -    15258596 chr11:5721414(+) A-I intron -    22327324 chr11:5721446(+) A-I intron -    22327324 chr11:5723325(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIM22	chr11:5711015-5711016(+) m6A 5'UTR       24981863 chr11:5711029-5711030(+) m6A 5'UTR       24981863 chr11:5711107-5711108(+) m6A 5'UTR//exon       24981863 chr11:5711122-5711123(+) m6A 5'UTR//exon       24981863 chr11:5712265-5712266(+) m6A 5'UTR//intron       24981863 chr11:5712373-5712374(+) m6A 5'UTR//intron       - chr11:5712389-5712390(+) m6A 5'UTR//intron       - chr11:5712398-5712399(+) m6A 5'UTR//intron       - chr11:5717420-5717421(+) m6A 5'UTR//exon       - chr11:5717435-5717436(+) m6A 5'UTR//exon       - chr11:5717484-5717485(+) m6A CDS//exon       - chr11:5717533-5717534(+) m6A CDS//exon       - chr11:5717642-5717643(+) m6A CDS//exon       - chr11:5717661-5717662(+) m6A CDS//exon       - chr11:5717770-5717771(+) m6A CDS//exon       24209618//24981863//26404942 chr11:5717821-5717822(+) m6A CDS//exon       24209618//24981863//26404942 chr11:5717833-5717834(+) m6A CDS//exon       24209618//24981863//26404942 chr11:5717849-5717850(+) m6A CDS//exon       24209618//24981863//26404942 chr11:5718045-5718046(+) m6A exon//intron       24981863 chr11:5718157-5718158(+) m6A exon//intron       24981863 chr11:5718172-5718173(+) m6A exon//intron       24981863 chr11:5718551-5718552(+) m6A CDS//exon//intron       24209618//24981863 chr11:5718561-5718562(+) m6A CDS//exon//intron       24981863 chr11:5718583-5718584(+) m6A exon//intron       24981863 chr11:5718605-5718606(+) m6A exon//intron       24981863 chr11:5718622-5718623(+) m6A exon//intron       24981863 chr11:5719458-5719459(+) m6A exon//intron       - chr11:5719512-5719513(+) m6A exon//intron       - chr11:5719564-5719565(+) m6A CDS//exon       - chr11:5719608-5719609(+) m6A CDS//exon       - chr11:5730648-5730649(+) m6A CDS//exon//intron       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-215-3p	Exosome HCC cell line (Hep3B|HepG2|PLC/PRF/5)     21721029 Exosome Ovarian follicular fluid     22116803 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	TRIM22	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-215-3p
Interactor2: TRIM22

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	29749134	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Con1b cells//Huh7.5.1 cells	Interactor2 expression	Downregulation
Description	Altogether, TRIM22 was confirmed as a direct target of miR-215 in Con1b and Huh7.5.1 cells.