Basic Information:

  VIRBase ID:  

HHID00019491

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-378e:  MIMAT0018927          IFNB1:  NM_002176     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-378e	IFNB1
miRBase Accession/Entrez ID	MIMAT0018927	3456
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-378e	rs1269022023 chr5:170028563    ACAT/A rs1298291117 chr5:170028555    G/A rs376752141 chr5:170028547    T/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFNB1	chr9:21077198-21077199(-) m6A 3'UTR       27773535 chr9:21077273-21077274(-) m6A 3'UTR       27773535 chr9:21077278-21077279(-) m6A 3'UTR       27773535 chr9:21077308-21077309(-) m6A CDS       27773535 chr9:21077328-21077329(-) m6A CDS       27773535 chr9:21077347-21077348(-) m6A CDS       27773535 chr9:21077375-21077376(-) m6A CDS       27773535 chr9:21077592-21077593(-) m6A CDS       27773535 chr9:21077611-21077612(-) m6A CDS       27773535 chr9:21077695-21077696(-) m6A CDS       27773535 chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-378e	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-378e
Interactor2: IFNB1

Evidence Support:

Strong-Evidence	RT-PCR
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	20969775	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Con1 cells	Interactor2 expression	None
Description	The result was that the expression level of 3 miRNAs (miR-27b, miR-378, miR-422b) in SVR was significantly higher than that in NR, whereas the expression level of 5 miRNAs (miR-34b, miR-145, miR-143, miR-652, and miR-18a) in SVR was significantly lower than that in NR.